Abstract: Disclosed are various embodiments relating to generating media item recommendations based upon determining a beats per minute value. A media recommendation application determines a beats per minute value based upon a pacing measurement of the user. The media recommendation application then identifies one or more media item having a beats per minute that is similar to the beats per minute value. The media recommendation application then identifies a subset of the media item candidates to surface as recommendations for the user.

Abstract: Architectures and techniques are described to provide personal remote storage space for electronic content items acquired (e.g., purchased) by a user of a client device. In some cases, as part of a transaction to acquire the electronic content item, an individual may receive an option that is selectable to indicate a preference to send electronic content items acquired by the individual to a personal remote storage space of the individual. When the option to store the electronic content item in the personal remote storage space is not selected by the individual, the electronic content item may be provided directly to a designated computing device of the individual.

Abstract: Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. In some cases, a client itself may generate a ranking of content sources for use in the selection of content sources. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Disclosed are various embodiments for processing file modifications in a networked storage system. A file is stored in a file system. If a modification listener is associated with the file, a notification that the file has been modified is sent to the modification listener. The modification listener can trigger processing of the file by executable code.

Abstract: Disclosed are various embodiments relating to generating media item recommendations based upon determining a beats per minute value. A media recommendation application determines a beats per minute value based upon the activity of a user. The media recommendation application then identifies one or more media item candidates having a number of beats per minute within a predefined delta of the beats per minute value. The media recommendation application then filters out the media items possessed and information associated with the user to identify a subset of the media item candidates to surface as recommendations.

Abstract: Disclosed are various embodiments of a file service which meters costs associated with aggregated file storage. A separate storage area is created for each of a plurality of cost center managers. A default storage area is created that is not associated with any of the cost center managers. Each storage area is divided into a plurality of logical partitions. Each logical partition corresponds to a content user. A content user is allowed to access a file in the corresponding logical partition of the corresponding storage area.

Abstract: Disclosed are various embodiments for processing file modifications in a networked storage system. A file is stored in a file system. If a modification listener is associated with the file, a notification that the file has been modified is sent to the modification listener. The modification listener can trigger processing of the file by executable code.

Abstract: Disclosed are various embodiments for storage of files. A removable memory device is configured to couple to a computing device, and a storage management application is stored in the removable memory device, the storage management application being executable by a processor circuit. The storage management application is configured to send a plurality of files for storage in a networked storage system, the networked storage system being remote to the computing device. The storage management system caches a subset of the files on the removable memory device and maintains a local file directory in the removable memory device. The local file directory lists the files stored in the networked storage system in association with an account linked to the removable memory device.

Abstract: Disclosed are various embodiments for a local networked storage that is linked to a remote networked storage system. In one embodiment, among others, a computing device obtains a request from a client device to read a file stored in a remote networked storage system. The computing device determines whether the file is stored in a local cache. The file is sent to the client device through a local network when the file is stored in the local cache. The computing device obtains the file from the remote networked storage system when the file is not stored in the local cache, where an indication of a user account is provided to the remote networked storage system. The file is sent to the client device in response to the file being obtained from the remote networked storage system.

Abstract: Disclosed are various embodiments for processing file modifications in a networked storage system. A file is stored in a file system. If a modification listener is associated with the file, a notification that the file has been modified is sent to the modification listener. The modification listener can trigger processing of the file by executable code.

Abstract: Disclosed are various embodiments for local networked storage that is linked to a remote networked storage system. In a client application, it is determined whether a local networked storage system is accessible to the client through a local network. A file is sent to the local networked storage system over the local network for storage by the local networked storage system when the local networked storage system is determined to be accessible to the client through the local network. A file is sent to a remote networked storage system over a remote network for storage by the remote networked storage system in association with a user account when the local networked storage system is determined not to be accessible through the local network.

Abstract: When a user receives digital content from a host over a network, such as streaming media, the user typically desires to receive a certain quality of the digital content with few or no interruptions. Techniques may be used to store and monitor a quality of digital content, a quality of the transmission of the digital content that is transmitted to a client device of a user, and/or the quality of rendering of the digital content by the client device. The techniques may provide restitution to the user when the quality of the digital content, transmission, and/or rendering thereof fails to comply with predetermined threshold values.

Abstract: Disclosed are various embodiments for processing file modifications in a networked storage system. A new version of a file is obtained from a client over a network. The new version of the file is stored in a file system maintained by a networked storage system. If a modification listener is associated with the file, a notification that the file has been modified is sent to the modification listener.

Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Abstract: An apparatus for determining freshness of wine stored in a container includes a housing, a gas sensor, an optical sensor pair, and electrical circuitry. The gas sensor is affixed to the housing such that it extends into a headspace of the container above the wine. The optical sensor pair is positioned such that the optical sensor pair extends into the headspace above the wine. The electrical circuitry is contained in the housing and is electrically interfaced to the gas sensor and to the optical sensor pair. The electrical circuitry operates the gas sensor to generate a series of gas level measurements and operates the optical sensor pair to generate a series of optical transmission measurements. A quality parameter corresponding to the freshness of the wine is determined based on both the series of gas level measurements and the series of optical transmission measurements.

Abstract: Various embodiments of a system and method for assignment and switching of content sources for a streaming content session are described. Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. In some cases, a client itself may generate a ranking of content sources for use in the selection of content sources. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Disclosed are various embodiments for making publisher content available to specific users. A directory describing media items that are remotely stored is presented via a user interface. Selection information corresponding to a particular media item is received via the user interface. The media item is requested and received from another computing device. Consumption data is collected during consumption of the media item. The consumption data is sent to another computing device.