Abstract: Disclosed are various embodiments for generating personalized streaming media based on a streaming media received from a broadcast source. In one embodiment, a media service receives a request to generate the personalized streaming media from a client. In response to the request, the media service application determines the content of the streaming media and identifies files in a file system of a user that include content related to the streaming media. Upon identifying the related files, the media service application embeds the content of the related files in a relevant portion of the streaming media to generate the personalized streaming media. The media service application then transmits the personalized streaming media to the client.

Abstract: Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. In some cases, a client itself may generate a ranking of content sources for use in the selection of content sources. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Various embodiments of a system and method for assignment and switching of content sources for a streaming content session are described. Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Compounds and compositions for promoting smoking cessation or decreasing tobacco use or nicotine addiction are provided. The compounds are 2?-fluoro-3?-(substituted phenyl) deschloroepibatidine analogs. The compounds have been found to modulate neuronal nicotine acetylcholine receptors and are useful in methods for the treatment of conditions or disorders influenced by the modulation of neuronal nicotinic acetylcholine receptors.

Abstract: An apparatus for determining freshness of wine stored in a container includes a housing, a gas sensor, an optical sensor pair, and electrical circuitry. The gas sensor is affixed to the housing such that it extends into a headspace of the container above the wine. The optical sensor pair is positioned such that the optical sensor pair extends into the headspace above the wine. The electrical circuitry is contained in the housing and is electrically interfaced to the gas sensor and to the optical sensor pair. The electrical circuitry operates the gas sensor to generate a series of gas level measurements and operates the optical sensor pair to generate a series of optical transmission measurements. A quality parameter corresponding to the freshness of the wine is determined based on both the series of gas level measurements and the series of optical transmission measurements.

Abstract: Compounds and compositions for promoting smoking cessation or decreasing tobacco use or nicotine addiction are provided. The compounds are 2?-fluoro-3?-(substituted phenyl) deschloroepibatidine analogs. The compounds have been found to modulate neuronal nicotine acetylcholine receptors and are useful in methods for the treatment of conditions or disorders influenced by the modulation of neuronal nicotinic acetylcholine receptors.

Abstract: Architectures and techniques are described to provide personal remote storage space for electronic content items acquired (e.g., purchased) by a user of a client device. In some cases, as part of a transaction to acquire the electronic content item, an individual may receive an option that is selectable to indicate a preference to send electronic content items acquired by the individual to a personal remote storage space of the individual. When the option to store the electronic content item in the personal remote storage space is not selected by the individual, the electronic content item may be provided directly to a designated computing device of the individual.

Abstract: Various embodiments of a system and method for assignment and switching of content sources for a streaming content session are described. Embodiments may include the generation and use of content source rankings for improving playback quality of content streams. In embodiments, a merchant system may collect and aggregate multiple quality metrics for different content streams that various content sources provide to various clients. The merchant system may utilize the quality metrics to generate rankings of content sources for clients. The merchant system may provide such rankings to clients to improve the content stream playback experience on the client. For instance, at content acquisition time, a client may request a content stream from a content resource ranked highest on a content source ranking provided by the merchant. If the content stream degrades, the client may source subsequent portions of the content stream from another highly ranked content source of the ranking.

Abstract: Disclosed are various embodiments for storage of files. A removable memory device is configured to couple to a computing device, and a storage management application is stored in the removable memory device, the storage management application being executable by a processor circuit. The storage management application is configured to send a plurality of files for storage in a networked storage system, the networked storage system being remote to the computing device. The storage management system caches a subset of the files on the removable memory device and maintains a local file directory in the removable memory device. The local file directory lists the files stored in the networked storage system in association with an account linked to the removable memory device.

Abstract: Disclosed are various embodiments for providing advertisements in association with recorded media items. For example, a broadcast media item is stored in a networked storage system in association with an account of a user for later consumption. At least one marker is located in the broadcast media item that identifies a first advertisement in the broadcast media item. One of a plurality of second advertisements is selected that targets the user to replace the first advertisement. The first advertisement is replaced with the selected one of the second advertisements in the broadcast media item.

Abstract: Disclosed are various embodiments for context-aware durability of variants of files. A first data store is associated with a first level of data durability, and a second data store is associated with a second level of data durability that is lower than the first level of data durability. A data object is stored in the second data store when the data object is a derivative of another data object stored in the first data store. A data object is stored in the first data store when the data object is not a derivative of another data object stored in the first data store.

Abstract: Beverage diagnostic and preservation devices and methods are described. In several exemplary embodiments, one or more of the devices are used to detect the freshness of, and/or preserve, wine in a container. The devices can receive inputs from one or more sensors when determining the freshness of wine in a container.

Abstract: Disclosed are various embodiments for storage of files. A portable memory device is configured to couple to a computing device, and a storage management application is stored in the portable memory device, the storage management application being executable by a processor circuit. The storage management application is configured to send a plurality of files for storage in a networked storage system, the networked storage system being remote to the computing device. The storage management system caches a subset of the files on the portable memory device and maintains a local file directory in the portable memory device. The local file directory lists the files stored in the networked storage system in association with an account linked to the portable memory device.

Abstract: Disclosed are various embodiments for the synchronizing of files between a networked storage system and a third party system. A file can be stored in a storage location in a networked storage system. A determination can be whether the storage location is associated with a third party system. An authentication credential can be retrieved that is associated with the third party system. Upload of the file to the third party system can be initiated.

Abstract: Compounds and compositions for promoting smoking cessation or decreasing tobacco use or nicotine addiction are provided. The compounds are 2?-fluoro-3?-(substituted phenyl) deschloroepibatidine analogs. The compounds have been found to modulate neuronal nicotine acetylcholine receptors and are useful in methods for the treatment of conditions or disorders influenced by the modulation of neuronal nicotinic acetylcholine receptors.

Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Abstract: Disclosed are various embodiments for making publisher content available to specific users. A directory describing media items that are remotely stored is presented via a user interface. Selection information corresponding to a particular media item is received via the user interface. The media item is requested and received from another computing device. Consumption data is collected during consumption of the media item. The consumption data is sent to another computing device.

Abstract: Disclosed are various embodiments for using a virtual file system interface to provide media titles from remotely located user-specific media storage. A selected media title and associated metadata is stored in a user-specific media storage area. The selection of a media title is based at least in part on user-specific consumption data. A request for the media title is received from a client. The requested media title and the associated metadata are provided to the client. Consumption data for the requested media title is received from the client.

Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal undergoing a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.