Abstract: Disclosed are various embodiments that provide file system merchandising. A file service maintains file systems associated with file service accounts. When accessing content of the file system through a network page, the network page includes a merchandising recommendation that is based at least in part upon characteristic information associated with the requested content. The merchandising recommendation may also be based at least in part upon account behavior history associated with the file service account. A link may be included in the merchandising recommendation to initiate previewing of at least a portion of a recommended item and/or to initiate acquisition of the recommended item.

Abstract: Disclosed are various embodiments relating to generating media item recommendations based upon determining a beats per minute value. A media recommendation application determines a beats per minute value based upon the activity of a user. The media recommendation application then identifies one or more media item candidates having a number of beats per minute within a predefined delta of the beats per minute value. The media recommendation application then filters out the media items possessed and information associated with the user to identify a subset of the media item candidates to surface as recommendations.

Abstract: The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.

Abstract: Disclosed are various embodiments that provide variants of files in a file system. Multiple file systems are maintained for multiple users. Each file system includes multiple files and one or more folder. Each file includes a respective unique identifier and a respective reference to a data object stored in one or more data store. Multiple file variants are maintained. Each file variant includes the respective unique identifier of a respective file. Each file variant also includes a respective reference to a secondary data object stored in the one or more data stores. The secondary data object is related to the primary data object referenced by the respective file.

Abstract: The present invention relates to compositions and methods for treating and preventing cocaine addiction. In particular, the present invention provides mutated cocaine esterase proteins for use in treating and preventing cocaine addiction.

Abstract: Disclosed are various embodiments for local networked storage that is linked to a remote networked storage system. In a client application, it is determined whether a local networked storage system is accessible to the client through a local network. A file is sent to the local networked storage system over the local network for storage by the local networked storage system when the local networked storage system is determined to be accessible to the client through the local network. A file is sent to a remote networked storage system over a remote network for storage by the remote networked storage system in association with a user account when the local networked storage system is determined not to be accessible through the local network.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C?O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.

Abstract: Disclosed are various embodiments for storage of files. A portable memory device is configured to couple to a computing device, and a storage management application is stored in the portable memory device, the storage management application being executable by a processor circuit. The storage management application is configured to send a plurality of files for storage in a networked storage system, the networked storage system being remote to the computing device. The storage management system caches a subset of the files on the portable memory device and maintains a local file directory in the portable memory device. The local file directory lists the files stored in the networked storage system in association with an account linked to the portable memory device.

Abstract: Disclosed are various embodiments that provide variants of files in a file system. Multiple file systems are maintained for multiple users. Each file system includes multiple files and one or more folder. Each file includes a respective unique identifier and a respective reference to a data object stored in one or more data store. Multiple file variants are maintained. Each file variant includes the respective unique identifier of a respective file. Each file variant also includes a respective reference to a secondary data object stored in the one or more data stores. The secondary data object is related to the primary data object referenced by the respective file.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula: wherein R1 is C1-6 alkyl or C3-6cycloalkyl; or wherein R2 is substituted with one or two halogen(s) or OC1-3alkyl.

Abstract: An application architecture comprises one or more audio interfaces placed within the premises of users. A cloud-based application engine receives audio information from the interfaces and provides information to cloud-based applications based on the audio within the user premises. The other applications utilize the information to provide or enhance services to the users.

Abstract: Architectures and techniques are described to provide personal remote storage space for electronic content items acquired (e.g., purchased) by a user of a client device. In some cases, as part of a transaction to acquire the electronic content item, an individual may receive an option that is selectable to indicate a preference to send electronic content items acquired by the individual to a personal remote storage space of the individual. When the option to store the electronic content item in the personal remote storage space is not selected by the individual, the electronic content item may be provided directly to a designated computing device of the individual.

Abstract: Potent and selective ligands for the dopamine 3 (D3) receptor are disclosed. The D3 receptor ligands have a structural formula (I) wherein X is C?O or SO2, R1 is C1-6 alkyl, R2 is aryl, heteroaryl, aryl, —(CH2)1-3aryl, or —(CH2)1-3heteroaryl, and n is 0 or 1. Methods of using the D3 receptor ligands in the treatment of diseases and conditions wherein modulation of the D3 receptor provides a benefit also are disclosed.

Abstract: Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided are methods of treating a mammal under-going a cocaine-induced condition. Methods of determining whether a compound is a thermostabilizing agent for a protein are also provided. Uses of the above-described compositions for the treatment of a cocaine-induced condition is additionally provided. Additionally provided is an isolated nucleic acid encoding a CocE polypeptide having the substitutions L169K and G173Q, and the CocE polypeptide encoded by that nucleic acid, and pharmaceutical compositions thereof. Further provided is the use of that composition for the manufacture of a medicament for the treatment of a cocaine-induced condition and for the treatment of a cocaine-induced condition.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.