Abstract: Plastisol compositions are disclosed containing methacrylate core/shell copolymer, non-phthalate ester plasticizers, pigment, filler, and thixotropic agent. Other additives are optional. The plasticizer is a blend of dibenzoate and DINCH. The plastisol can be used an ink of various colors for use in application to textiles. The plastisol compositions avoid polyvinyl chloride polymer resins and phthalate plasticizers conventionally employed in plastisol inks.

Abstract: A conductive composition includes a mono-acid hybrid that includes an unprotected, single reactive group. The mono-acid hybrid may include substantially non-reactive groups elsewhere such that the mono-acid hybrid is functional as a chain terminator. Methods and devices using the compositions are also disclosed.

Abstract: The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Abstract: A cord material dispenser comprising a container including a surrounding sidewall having first and second openings and first and second cord materials disposed in the container. The first and second cord materials are dispensable through their respective first and second openings. The first cord material is preferably wound around a first spool and the second cord material is preferably wound around a second spool. The dispenser may include a first quantity of the first cord material and a second quantity of the second cord material, wherein the first quantity is less than the second quantity. For example, the first quantity may be one fourth of the second quantity. Preferably, the container includes indicia indicative of the ratio of the first quantity to the second quantity. The indicia may be in the form of a graphic representative of the intended use of the spooled materials.

Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1, 4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

Abstract: The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

Abstract: The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase. The disclosure also relates to pharmaceutically acceptable compositions comprising the compounds of the disclosure; methods of treating of various diseases, disorders, and conditions using the compounds of the disclosure; processes for preparing the compounds of the disclosure; intermediates for the preparation of the compounds of the disclosure; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.

Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: An improved pilot valve assembly (14) for hydraulically controlling a pressure reducing valve (12) to maintain and further vary the outlet pressure (P2) of the pressure reducing valve (12) in response to increased flow (f) through the valve (12). The pilot valve assembly (14) comprising first and second movable valve members (100,102). The first and second moveable members (100,102) being acted on by a velocity head pressure sensed by a downstream Pitot tube (90) and a downstream outlet pressure (P2) in a balanced arrangement such that they move in response to both the velocity head and downstream pressure (P2) to open and close the pilot valve (14) and so main valve (12) to both maintain and vary the outlet pressure (P2).

Abstract: Plastisol compositions are disclosed containing methacrylate core/shell copolymer, non-phthalate ester plasticizers, pigment, filler, and thixotropic agent. Other additives are optional. The plasticizer is a blend of dibenzoate and DINCH. The plastisol can be used an ink of various colors for use in application to textiles. The plastisol compositions avoid polyvinyl chloride polymer resins and phthalate plasticizers conventionally employed in plastisol inks.

Abstract: The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith.

Abstract: A principal catch basin defining a certain storage capacity, the catch basin situated below the level of the ground, having an upper level opening for receiving surface water drainage thereunto, and having side walls partially constructed of permeable geotextile fabric for allowing water flow into the permeable basin to serve as a collection for sub-surface drainage. The system would include the ability to automatically pump the drainage water out using the energy of a pressurized water system in conjunction with a venturi pump without the need of any electrical sensors or signals. In addition, there may be a plurality of collection basins which could be joined together as a system to pump the water from various locations through one transport line.

Abstract: A cord material dispenser comprising a container including a surrounding sidewall having first and second openings and first and second cord materials disposed in the container. The first and second cord materials are dispensable through their respective first and second openings. The first cord material is preferably wound around a first spool and the second cord material is preferably wound around a second spool. The dispenser may include a first quantity of the first cord material and a second quantity of the second cord material, wherein the first quantity is less than the second quantity. For example, the first quantity may be one fourth of the second quantity. Preferably, the container includes indicia indicative of the ratio of the first quantity to the second quantity. The indicia may be in the form of a graphic representative of the intended use of the spooled materials.

Abstract: A system and method for wireless communication. The system can include a transmitter that transmits a data signal having a time period without data transmission. The system can also include a receiver including a first antenna, a second antenna, a switch that activates one of the first antenna and the second antenna, and a processor that estimates a first signal-to-noise ratio for the first antenna and a second signal-to-noise ratio for the second antenna during the time period without data transmission. The processor can control the switch to select one of the first antenna and the second antenna based on a comparison between the first signal-to-noise ratio and the second signal-to-noise ratio.

Abstract: A conductive composition includes a mono-acid hybrid that includes an unprotected, single reactive group. The mono-acid hybrid may include substantially non-reactive groups elsewhere such that the mono-acid hybrid is functional as a chain terminator. Methods and devices using the compositions are also disclosed.

Abstract: A method, apparatus and computer program product are provided for implementing deterministic based broken scan chain diagnostics. A deterministic test pattern is generated and is loaded into each scan chain in the device under test using lateral insertion via system data ports applying system clocks. Then each scan chain is unloaded and a last switching latch is identified. The testing steps are repeated a selected number of times. Then checking for consistent results is performed. When consistent results are identified, then the identified last switching latch is sent to a Physical Failure Analysis system.

Abstract: The present invention relates to compounds useful as promoters of the SMN2 gene. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of Spinal Muscular Atrophy.

Abstract: A method, apparatus and computer program product are provided for implementing deterministic based broken scan chain diagnostics. A deterministic test pattern is generated and is loaded into each scan chain in the device under test using lateral insertion via system data ports applying system clocks. Then each scan chain is unloaded and a last switching latch is identified. The testing steps are repeated a selected number of times. Then checking for consistent results is performed. When consistent results are identified, then the identified last switching latch is sent to a Physical Failure Analysis system.

Abstract: A method, apparatus and computer program product are provided for implementing deterministic based broken scan chain diagnostics. A deterministic test pattern is generated and is loaded into each scan chain in the device under test using lateral insertion via system data ports applying system clocks. Then each scan chain is unloaded and a last switching latch is identified. The testing steps are repeated a selected number of times. Then checking for consistent results is performed. When consistent results are identified, then the identified last switching latch is sent to a Physical Failure Analysis system.