Patents by Inventor James Patrick Dunn

James Patrick Dunn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • JNK modulators
    Patent number: 8399462
    Abstract: Compounds of formula I modulate JNK: wherein the variables are as defined herein.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 19, 2013
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Leyi Gong, David Michael Goldstein, Xiaochun Han, Joan Heather Hogg, Wylie Solang Palmer, Lubica Raptova, Tania Silva, Parcharee Tivitmahaisoon, Teresa Alejandra Trejo-Martin, Christophe Michoud, Achyutharao Sidduri
  • Methods for treating retroviral infections
    Patent number: 8329755
    Abstract: The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein with at least one carrier, excipient or diluent.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: December 11, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Donald Roy Hirschfeld, Tania Silva, Zachary Kevin Sweeney, Harit Vora
  • Heterocyclic antiviral compounds
    Patent number: 8293778
    Abstract: The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
    Type: Grant
    Filed: February 20, 2010
    Date of Patent: October 23, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Todd Richard Elworthy, Dimitrios Stefanidis, Zachary Kevin Sweeney
  • Inhibitors of JNK
    Patent number: 8183254
    Abstract: The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 and Z2 are as defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
    Type: Grant
    Filed: May 14, 2009
    Date of Patent: May 22, 2012
    Assignee: Roche Palo Alto LLC
    Inventors: Humberto Bartolome Arzeno, James Patrick Dunn, David Michael Goldstein, Leyi Gong, Xiaochun Han, Joan Heather Hogg, Alam Jahangir, Wylie Solang Palmer, Deborah Carol Reuter, Tania Silva, Parcharee Tivitmahaisoon, Teresa Alejandra Trejo-Martin, Shao-Yong Wu
  • HETEROCYCLIC ANTIVIRAL COMPOUNDS
    Publication number: 20110207688
    Abstract: The present invention relates to a method of treating an HIV-I infection with a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
    Type: Application
    Filed: February 20, 2010
    Publication date: August 25, 2011
    Inventors: James Patrick Dunn, Todd Richard Elworthy, Dimitrios Stefanidis, Zachary Kevin Sweeney
  • Heterocyclic antiviral compounds
    Patent number: 7666891
    Abstract: The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficiency virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficiency virus containing a compound according to formula I where R1, R2, R3, R4, R5, are as defined herein.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: February 23, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Todd Richard Elworthy, Dimitrios Stefanidis, Zachary Kevin Sweeney
  • METHODS FOR TREATING RETROVIRAL INFECTIONS
    Publication number: 20100041648
    Abstract: The present invention provides compositions for treating an HIV infection comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein with at least one carrier, excipient or diluent.
    Type: Application
    Filed: October 27, 2009
    Publication date: February 18, 2010
    Inventors: James Patrick Dunn, Donald Roy Hirschfeld, Tania Silva, Zachary Kevin Sweeney, Harit Vora
  • Inhibitors of JNK
    Publication number: 20090318484
    Abstract: The invention relates to prodrugs of JNK inhibitors and corresponding methods, formulations, and compositions for inhibiting JNK and treating JNK-mediated disorders. The application discloses prodrugs of JNK inhibitors, as described below in formula I: wherein m, n, p, q, Q, r, R1, R2, R3, X, X1, X2, X3, X4, X5, Y1, Y2, Z1 and Z2 areas defined herein. The compounds and compositions disclosed herein are useful to modulate the activity of JNK and treat diseases associated with JNK activity. Disclosed are methods and formulations for inhibiting JNK and treating JNK-mediated disorders, and the like, with the compounds, and processes for making said compounds, and corresponding compositions, disclosed herein.
    Type: Application
    Filed: May 14, 2009
    Publication date: December 24, 2009
    Inventors: Humberto Bartolome Arzeno, James Patrick Dunn, David Michael Goldstein, Leyi Gong, Xiaochun Han, Joan Heather Hogg, Alam Jahangir, Wylie Solang Palmer, Deborah Carol Reuter, Tania Silva, Parcharee Tivitmanhaisoon, Teresa Alejandra Trejo-Martin, Shao-Yong Wu
  • Methods for treating retroviral infections
    Patent number: 7625949
    Abstract: The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1-R5, R11c and X1 are as defined herein.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: December 1, 2009
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Donald Roy Hirschfeld, Tania Silva, Zachary Kevin Sweeney, Harit Vora
  • Substituted quinazoline compounds useful as p38 kinase inhibitors
    Patent number: 7456185
    Abstract: Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and R7 are optional substituents, and Q is a non-aromatic moiety as defined in the specification.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: November 25, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl, Teresa Alejandra Trejo-Martin
  • 6-Substituted pyrido-pyrimidines
    Patent number: 7449581
    Abstract: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
    Type: Grant
    Filed: January 9, 2007
    Date of Patent: November 11, 2008
    Assignee: Poche Palo Alto LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • JNK modulators
    Publication number: 20080146565
    Abstract: Compounds of formula I modulate JNK: wherein the variables are as defined herein.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 19, 2008
    Inventors: James Patrick Dunn, Leyi Gong, David Michael Goldstein, Xiaochun Han, Joan Heather Hogg, Wylie Solang Palmer, Lubica Raptova, Tania Silva, Parcharee Tivitmahaisoon, Teresa Alejandra Trejo-Martin, Christophe Michoud, Achyutharao Sidduri
  • Nonnucleoside reverse transcriptase inhibitors
    Patent number: 7348345
    Abstract: This invention relates to methods of treating an HIV infection with novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts, and methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I.
    Type: Grant
    Filed: February 2, 2007
    Date of Patent: March 25, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Steven Swallow, Zachary Kevin Sweeney
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7288542
    Abstract: The present invention relates to a compounds according to formula I, methods for treating diseases mediated by human immunodeficieny virus by administration of a compound according to formula I and pharmaceutical compositions for treating diseases mediated by human immunodeficieny virus containing a compound according to formula I where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: October 30, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Todd Richard Elworthy, Joan Heather Hogg, Dimitrios Stefanidis
  • Nonnucleoside reverse transcriptase inhibitors
    Patent number: 7241794
    Abstract: This invention relates to novel pyrazole derivatives of formula I wherein R1 to R4 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I and pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: July 10, 2007
    Assignee: RochePalo Alto LLC
    Inventors: James Patrick Dunn, Joan Heather Hogg, Taraneh Mirzadegan, Steven Swallow
  • Substituted quinazoline compounds useful as p38 kinase inhibitors
    Patent number: 7238698
    Abstract: Compounds having the formula (I), are useful as p38 kinase inhibitors, wherein R4 and R5 are hydrogen, halogen, cyano, haloalkyl, or haloalkoxy, but are not both hydrogen; R6 and R7 are optional substituents, and Q is a non-aromatic moiety as defined in the specification.
    Type: Grant
    Filed: April 15, 2004
    Date of Patent: July 3, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl, Teresa Alejandra Trejo-Martin
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7208509
    Abstract: This invention relates to novel heterocyclic compounds of formula I wherein R1—R4, X1 and X2 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: April 24, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Steven Swallow, Zachary Kevin Sweeney
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7189718
    Abstract: This invention relates to novel pyridazinone derivatives of formula I wherein R1–R4, R7, R8 and X1 are as defined in the summary and pharmaceutically acceptable salts and solvates thereof, methods to inhibit or modulate Human Immunodeficiency Virus (HIV) reverse transcriptase with compounds of formula I, pharmaceutical compositions containing of formula I admixed with at least one solvent, carrier or excipient and processes to prepare compounds of formula I.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: March 13, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Brian William Dymock, Taraneh Mirzadegan, Eric Brian Sjogren, Steven Swallow, Zachary Kevin Sweeney
  • 6-substituted pyrido-pyrimidines
    Patent number: 7169794
    Abstract: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: January 30, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • Non-nucleoside reverse transcriptase inhibitors
    Patent number: 7166738
    Abstract: The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1—R5, R7a, R7b, R7c, R8—R10, X1, X2 m, n, o and p are as defined herein
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: January 23, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: James Patrick Dunn, Donald Roy Hirschfeld, Tania Silva, Zachary Kevin Sweeney, Harit Vora