Abstract: A method of point cloud generation comprises generating, by a processor, a first point cloud comprising a first set of generated data points; calculating, by the processor, a loss function representative of the quality of the first point cloud, the loss function comprising a smoothness term obtained by constructing vectors between neighbouring data points in the point cloud, performing vector multiplication between neighbouring pairs of vectors, and outputting a smoothness term based on the result of the vector multiplication; and generating, by the processor, a second point cloud comprising a second set of generated data points based at least in part on the calculated loss function of the first point cloud.

Abstract: A ventilated structural panel comprising a first sheet, having a long axis defining a length and a perpendicular short axis defining a width, a plurality of spacing structural elements, fixedly attached to the first sheet such that the yield strength of the panel is greater than the individual yield strength of the first sheet, and the plurality of spacing structural elements being formed such that a plurality of unobstructed pathways are created for air to move from at least one edge of the panel to at least one of an opposite and an adjacent edge of the panel, wherein the first sheet is the only sheet in the panel.

Abstract: A method includes receiving a frequency-domain representation of an output audio signal output from a linear acoustic echo canceller (LAEC). The output audio signal includes target speech captured by an audio capture device of a user device and residual echo of reference audio output by an audio output device of the user device. The method also includes receiving a frequency-domain representation of the reference audio and determining, using a neural echo suppressor (NES), based on the frequency-domain representation of the output audio signal and the frequency-domain representation of the reference audio, a time-frequency mask. The method also includes processing, using the time-frequency mask, the frequency-domain representation of the output audio signal to attenuate the residual echo in an enhanced audio signal.

Abstract: Pyrrolobenzodiazepine (PBD) intermediates, including useful in the preparation of advanced intermediates. PBDs, and PBD dimers. Such PBD intermediates provide several advantages, including simplified synthesis of desired PBD products, greater substrate compatibility, and safer reaction conditions.

Abstract: A method for automatic speech recognition using joint acoustic echo cancellation, speech enhancement, and voice separation includes receiving, at a contextual frontend processing model, input speech features corresponding to a target utterance. The method also includes receiving, at the contextual frontend processing model, at least one of a reference audio signal, a contextual noise signal including noise prior to the target utterance, or a speaker embedding including voice characteristics of a target speaker that spoke the target utterance. The method further includes processing, using the contextual frontend processing model, the input speech features and the at least one of the reference audio signal, the contextual noise signal, or the speaker embedding vector to generate enhanced speech features.

Abstract: A method of forming an overlay between cutter pockets of a polycrystalline diamond rock bit includes inserting a plurality of ceramic dams respectively into the cutter pockets of the rock bit, and applying a hardfacing material using a plasma arc welding process onto a substrate of the rock bit in spaces between the ceramic dams so as to form the overlay. The ceramic dams are electrically non-conductive. Each of the ceramic dams has a cylindrical shape. The cutter pockets are drilled into the substrate of the rock bit. The ceramic dams are inserted into the respective drilled cutter pockets prior to the step of applying the hardfacing material. The ceramic dams can be removed and polycrystalline diamond bits inserted into the pockets.

Abstract: A polydiorganosiloxane having both a silicon bonded aliphatically unsaturated group and a silicon bonded poly(meth)acrylate polymer or copolymer, and method for preparation of this polydiorganosiloxane are disclosed. The method preserves the aliphatically unsaturated groups when grafting the poly(meth)acrylate to the polydiorganosiloxane. This polydiorganosiloxane is useful in hydrosilylation reaction curable compositions, such as pressure sensitive adhesive compositions.

Abstract: A method for automatic speech recognition using joint acoustic echo cancellation, speech enhancement, and voice separation includes receiving, at a contextual frontend processing model, input speech features corresponding to a target utterance. The method also includes receiving, at the contextual frontend processing model, at least one of a reference audio signal, a contextual noise signal including noise prior to the target utterance, or a speaker embedding including voice characteristics of a target speaker that spoke the target utterance. The method further includes processing, using the contextual frontend processing model, the input speech features and the at least one of the reference audio signal, the contextual noise signal, or the speaker embedding vector to generate enhanced speech features.

Abstract: A method of point cloud generation comprises generating, by a processor, a first point cloud comprising a first set of generated data points; calculating, by the processor, a loss function representative of the quality of the first point cloud, the loss function comprising a smoothness term obtained by constructing vectors between neighbouring data points in the point cloud, performing vector multiplication between neighbouring pairs of vectors, and outputting a smoothness term based on the result of the vector multiplication; and generating, by the processor, a second point cloud comprising a second set of generated data points based at least in part on the calculated loss function of the first point cloud.

Abstract: A polydiorganosiloxane having both a silicon bonded aliphatically unsaturated group and a silicon bonded poly(meth)acrylate polymer or copolymer, and method for preparation of this polydiorganosiloxane are disclosed. The method preserves the aliphatically unsaturated groups when grafting the poly(meth)acrylate to the polydiorganosiloxane. This polydiorganosiloxane is useful in hydrosilylation reaction curable compositions, such as pressure sensitive adhesive compositions.

Abstract: A polydiorganosiloxane having both a silicon bonded aliphatically unsaturated group and a silicon bonded poly(meth)acrylate polymer or copolymer, and method for preparation of this polydiorganosiloxane are disclosed. The method preserves the aliphatically unsaturated groups when grafting the poly(meth)acrylate to the polydiorganosiloxane. This polydiorganosiloxane is useful in hydrosilylation reaction curable compositions, such as pressure sensitive adhesive compositions.

Abstract: Methods for making a dolastatin, auristatin or related compounds comprising the steps of providing a universal dolastatin core of Formula (I) reacting the C-terminal carboxylic acid group with an amine (A) to form an amide bond and reacting the N-terminal amine with a carboxylic acid (CA) to form an amide bond, wherein the steps can be performed in either order. Also provided are an isolated salt of the universal dolastatin core for use in preparation of dolastatins, auristatins and related compounds. Also provided are a number of intermediates and process steps which are useful for the preparation of high purity dolastatin core and high purity dolastatin and auristatin compounds.

Abstract: A method for automatic speech recognition using joint acoustic echo cancellation, speech enhancement, and voice separation includes receiving, at a contextual frontend processing model, input speech features corresponding to a target utterance. The method also includes receiving, at the contextual frontend processing model, at least one of a reference audio signal, a contextual noise signal including noise prior to the target utterance, or a speaker embedding including voice characteristics of a target speaker that spoke the target utterance. The method further includes processing, using the contextual frontend processing model, the input speech features and the at least one of the reference audio signal, the contextual noise signal, or the speaker embedding vector to generate enhanced speech features.

Abstract: A method of constructing a building comprising the steps of attaching a first panel to a second panel. The first panel is one of a single plenum panel and a multi-plenum panel and the second panel is one of a single plenum panel and a multi-plenum panel.

Abstract: Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.

Abstract: A polydiorganosiloxane having both a silicon bonded aliphatically unsaturated group and a silicon bonded poly(meth)acrylate polymer or copolymer, and method for preparation of this polydiorganosiloxane are disclosed. The method preserves the aliphatically unsaturated groups when grafting the poly(meth)acrylate to the polydiorganosiloxane. This polydiorganosiloxane is useful in hydrosilylation reaction curable compositions, such as pressure sensitive adhesive compositions.

Abstract: A ventilated structural panel comprising a first sheet, having a long axis defining a length and a perpendicular short axis defining a width, a plurality of spacing structural elements, fixedly attached to the first sheet such that the yield strength of the panel is greater than the individual yield strength of the first sheet, and the plurality of spacing structural elements being formed such that a plurality of unobstructed pathways are created for air to move from at least one edge of the panel to at least one of an opposite and an adjacent edge of the panel, wherein the first sheet is the only sheet in the panel.

Abstract: A method of constructing a building comprising the steps of attaching a first panel to a second panel. The first panel is one of a single plenum panel and a multi-plenum panel and the second panel is one of a single plenum panel and a multi-plenum panel.

Abstract: A real-time, interactive incident reporting and alert system and method is provided. The system includes at least one server configured to: receive, from a user device, an incident report, the incident report including an identifier of a user associated with the user device, a location associated with an incident, and information relating to the incident; identify a plurality of users in proximity to the location; and transmit an alert to a plurality of user devices associated with the plurality of users to inform the plurality of users of the incident.

Abstract: A method of constructing a building comprising the steps of attaching a first panel to a second panel. The first panel is one of a single plenum panel and a multi-plenum panel and the second panel is one of a single plenum panel and a multi-plenum panel.