Abstract: A polydiorganosiloxane having both a silicon bonded aliphatically unsaturated group and a silicon bonded poly(meth)acrylate polymer or copolymer, and method for preparation of this polydiorganosiloxane are disclosed. The method preserves the aliphatically unsaturated groups when grafting the poly(meth)acrylate to the polydiorganosiloxane. This polydiorganosiloxane is useful in hydrosilylation reaction curable compositions, such as pressure sensitive adhesive compositions.

Abstract: Methods for making a dolastatin, auristatin or related compounds comprising the steps of providing a universal dolastatin core of Formula (I) reacting the C-terminal carboxylic acid group with an amine (A) to form an amide bond and reacting the N-terminal amine with a carboxylic acid (CA) to form an amide bond, wherein the steps can be performed in either order. Also provided are an isolated salt of the universal dolastatin core for use in preparation of dolastatins, auristatins and related compounds. Also provided are a number of intermediates and process steps which are useful for the preparation of high purity dolastatin core and high purity dolastatin and auristatin compounds.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: A computer-implemented method comprises generating computer executable code as one or more code portions; detecting a number of processing operations required to reach one or more predetermined stages in execution of each code portion; and associating with each code portion one or more progress indicators, each representing a respective execution stage of the one or more predetermined stages within execution of that code portion. The code portions are executed by a processor powered by an unpredictable power source. When the processor detects an energy condition indicating that no more than a reserve quantity of electrical energy is available, the progress indicators are used to determine whether or not to perform a checkpoint.

Abstract: A method for automatic speech recognition using joint acoustic echo cancellation, speech enhancement, and voice separation includes receiving, at a contextual frontend processing model, input speech features corresponding to a target utterance. The method also includes receiving, at the contextual frontend processing model, at least one of a reference audio signal, a contextual noise signal including noise prior to the target utterance, or a speaker embedding including voice characteristics of a target speaker that spoke the target utterance. The method further includes processing, using the contextual frontend processing model, the input speech features and the at least one of the reference audio signal, the contextual noise signal, or the speaker embedding vector to generate enhanced speech features.

Abstract: A digital crosspoint switch of a network switching system (NSS) replicates input data received via a first network interface to a first data processing port of a data processing card. The input data includes a digital market data feed comprising market-data packets. The crosspoint switch has internal crosspoint ports and external crosspoint ports. The data processing card includes a programmable logic device and a plurality of data processing ports connected to the internal crosspoint ports. The NSS includes a plurality of network interfaces connected to the external crosspoint ports. The data processing card processes the input data and generates processed data on the second data processing port at least in part by only including market-data packets that meet a first predetermined filtering criterion in the processed data. The crosspoint switch replicates the processed data from the second data processing port to the second network interface.

Abstract: An interposer is described that is made from an electrically insulating, thermally efficient substrate (e.g., sapphire) and has a load hole for use with ion traps in atomic-based QIP architectures. The interposer load hole aligns with a load hole in the ion trap such that atomic species can be provided from the back of the interposer to the front of the ion trap for ionization and confinement. The interposer may include angled traces for wire bonding to the ion trap, where the angled traces enable more open light access when using laser or optical beams during operation of the ion trap. Electrical routing in the interposer may involve more than one layer of routing, separated by an insulating dielectric material such as a polyimide. Routing in the interposer may also contain active electronic components. The load hole in the interposer may have a straight or tapered inner wall.

Abstract: Presently disclosed are systems and methods for generating customized filtered-and-partitioned market-data feeds. In an embodiment, an output-feed profile is maintained in data storage at a market-data-processing device (MDPD). The output-feed profile specifies a subset of ticker symbols and a ticker-symbol-based feed-partitioning scheme. An input feed of order-book updates to ticker symbols is received at the MDPD from an upstream device. At the MDPD, a customized market-data output feed is generated according to the maintained output-feed profile at least in part by filtering the input feed down to the order-book updates to ticker symbols in the specified subset and partitioning the filtered feed according to the specified ticker-symbol-based feed-partitioning scheme. The customized market-data output feed is transmitted from the MDPD to a downstream device.

Abstract: A display device includes a plurality of light emitting diodes (LEDs) having walls that extend through a transparent semiconductor layer and beyond the surface of the transparent semiconductor layer. Each of the walls surrounds at least part of each of the plurality of LEDs to collimate the light emitted by the plurality of LEDs. In some embodiments, the walls collimate the light emitted by the LEDs by reflecting the light or absorbing a portion of the light. The display device may further include an array of optical lenses that faces the surface of the transparent semiconductor layer to further collimate the light emitted from the LEDs.

Abstract: A method for analyzing a virtual object in a virtual environment includes obtaining an image of a first real-world object and transmitting, to a data processing system, the image of the first real-world object. The method includes creating a digital representation of the first real-world object and assigning local attributes to one or more portions of the digital representation corresponding to elements of the first real-world object. The method includes obtaining an image of an updated configuration of the first real-world object and transmitting, to the data processing system, the image of the updated configuration. The method includes creating, by the data processing system, a digital representation, of the updated configuration. The method includes comparing, by the data processing system, the digital representation of the first real-world object and the digital representation of the updated first real-world object to identify rearranged parts and assign local attributes.

Abstract: A method of constructing a building comprising the steps of attaching a first panel to a second panel. The first panel is one of a single plenum panel and a multi-plenum panel and the second panel is one of a single plenum panel and a multi-plenum panel.

Abstract: A display device includes a plurality of light emitting diodes (LEDs) having walls that extend through a transparent semiconductor layer and beyond the surface of the transparent semiconductor layer. Each of the walls surrounds at least part of each of the plurality of LEDs to collimate the light emitted by the plurality of LEDs. In some embodiments, the walls collimate the light emitted by the LEDs by reflecting the light or absorbing a portion of the light. The display device may further include an array of optical lenses that faces the surface of the transparent semiconductor layer to further collimate the light emitted from the LEDs.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: Provided herein are methods, systems, and compositions for determining a base in a polynucleotide. In various aspects, the methods, systems, and compositions presented herein are useful for performing 4-base, 5-base, or 6-base sequencing of polynucleotide molecules, for example, from liquid biopsy samples or wherein the base is a low frequency mutation.

Abstract: In some examples, an apparatus includes a management controller for use in a computer system having a processing resource for executing an operating system (OS) of the computer system, the management controller being separate from the processing resource and to perform, based on operation of the management controller within a cryptographic boundary, management of components of the computer system, the management of components comprising power control of the computer system. The management controller is to receive sensor data, perform facial recognition based on the sensor data, and determine whether to initiate a security action responsive to the facial recognition.

Abstract: A computer-implemented method for creating a virtual object; the method comprising: obtaining a digital representation of a real-world object, the digital representation representing a visual appearance of a shape of the real-world object; obtaining an input indicative of one or more properties of an entity different from the real-world object; creating a virtual object representing the real-world object; and assigning, based on at least the obtained input, an attribute to the created virtual object.

Abstract: An interactive music play system, comprising a plurality of toy elements, an image capturing device, a processing unit and a music rendering device; wherein the image capturing device is configured to capture one or more images of a user-selected subset of said toy elements arranged in a field of view of the image capturing device; wherein the processing unit is configured to: recognise the user-selected subset of toy elements in the one or more captured images; create a musical presentation based on one or more of the recognised toy elements; cause the music rendering device to present the created musical presentation to the user.

Abstract: A medical intervention control system for providing a risk analysis and influencing intervention action on a patient, the system comprising: a database with a data set containing data from at least one data source comprising: a) study data; and b) sensed data; a waveform detector operable to identify a waveform from a data source, extract the waveform, categorise the waveform, normalise the waveform to a predetermined format and determine waveform characteristics and parameters of the waveform, the waveform detector populating part of the sensed data; a measurement module to derive subject data from the patient; an analyser operable to analyse the subject data with respect to the data set from the at least one data source and output an associated probability for each of one or more outcomes, wherein the associated probability is affected by an intervention, wherein the analyser takes subject data derived from the patient and tests for outcomes and potential interventions which influence the outcomes; an actio

Abstract: Methods and systems for computing distance data for a structure. A scan surface that represents an inspection area of the structure is identified. A plurality of sample points on an outer surface identified from a model of the structure and a corresponding plurality of projected points on an inner surface identified from the model of the structure are generated using the scan surface, a first geometric representation of the outer surface, and a second geometric representation of the inner surface. Distance data is computed using the plurality of sample points and the corresponding plurality of projected points. The distance data identifies a distance between a point pair formed by a sample point of the plurality of sample points and a corresponding projected point of the corresponding plurality of projected points.