Abstract: An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: Certain embodiments of the present application relate to an unmanned aerial vehicle including a control system, at least one rotor, a line, and a load sensor. The load sensor includes an actuating arm engaged with the line, and the load sensor is operable to detect a loaded/unloaded state of the line based on a position of the actuating arm. The line places the actuating arm in a depressed position when a parcel is supported by the line to thereby indicate the loaded/unloaded as a loaded state. The line permits the actuating arm to adopt a projected position when the parcel is not supported by the line to thereby indicate the loaded/unloaded as a loaded state. The control system is configured to raise and/or lower the free portion of the line based upon the loaded/unloaded state of the line.

Abstract: Systems and methods are provided for integrated healthcare management. The systems and methods include establishing a medical record data, accessing information about a treatment related to the medical record data, obtaining biometric data related to the treatment, processing the biometric data, determining whether the treatment is appropriate with respect to the biometric data, in response to the treatment being appropriate with respect to the biometric data, administering medication, and in response the treatment not being appropriate with respect to the biometric data, determining a new treatment, and administering new medication based on the new treatment.

Abstract: A block-based storage system hosts logical volumes that are implemented via multiple replicas of volume data stored on multiple resource hosts in different failure domains. Also, the block-based storage service allows multiple client computing devices to attach to a same given logical volume at the same time. In order to prevent unnecessary failovers, a primary node storing a primary replica is configured with a health check application programmatic interface (API) and a secondary node storing a secondary replica determines whether or not to initiate a failover based on the health of the primary replica.

Abstract: Broadly speaking, embodiments of the present techniques provide haptic button assemblies in which the haptic button has a low profile while still providing a satisfying tactile response or sensation to a user. Advantageously, the haptic button assemblies may have a profile that, for example, enables the assembly to be incorporated into the free space along an edge of a portable computing device. The haptic assemblies may, for example, be arranged to move the button perpendicularly with respect to the edge of the device.

Abstract: A system that enables searching for representing listings for accommodation reservations on a map is described. The system receives, by a network site of a listing network platform, input comprising search criteria associated with a geographical region and identifies a plurality of listings matching the search criteria. The system identifies a first subset listings of the plurality of listings that is each associated with a respective location that is within a boundary associated with the geographical region and a second subset listings of the plurality of listings that is each associated with a respective location that is outside the boundary associated with the geographical region. The system visually distinguishes the first subset of listings from the second subset of listings on a map-based graphical user interface (GUI) that represents the plurality of listings matching the search criteria.

Abstract: Techniques regarding post polymerization modifications to polycarbonate polymers via a flow reactor are provided. For example, one or more embodiments described herein can comprise a cyclic carbonate monomer that can be employed to facilitate polymerization of one or more polycarbonate platforms susceptible to post polymerization modification. For instance, one or more embodiments can regard a cyclic carbonate molecular backbone covalently bonded to an aryl halide functional group via in accordance with a chemical structure selected from the group consisting of: In the chemical structures, “R1” can be selected from the group consisting of a hydrogen atom and a functional group comprising a first alkyl group; “L” can represent a linkage group, comprising: a second alkyl group and an end group having at least one member selected from the group consisting of an oxygen atom and a nitrogen atom; and “A” can represent the aryl halide functional group.

Abstract: The disclosed method includes observing a utilization of a target sub-component of a functional unit of a processor using a control circuit coupled to the target sub-component. The method also includes detecting that the utilization is outside a desired utilization range and throttling one or more sub-components of the functional unit to reduce a power consumption of the functional unit. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.

Abstract: Various schemes pertaining to coordinated time-division multiple-access (C-TDMA) protocols, transmission opportunity (TXOP) sharing modes for time allocation, and exchange of parameters in multi-access point (multi-AP) systems are described. An apparatus (e.g., a sharing access point (AP)) acquires a TXOP. The apparatus also triggers one or more shared APs to participate in C-TDMA communications with respectively associated stations (STAs) within the TXOP.

Abstract: Ingredient dispensers for use in dispensing a measured amount of dry and/or liquid ingredient for a user are disclosed. In some embodiments, a dry ingredient dispenser is provided and may include a receptacle configured to contain a select amount of dry ingredient and a cap comprising an actuating portion and a measuring chamber portion. In some embodiments, a liquid ingredient dispenser is provided and may include a receptacle configured to contain a select amount of liquid ingredient and a dispensing portion which may be rotatable to dispense a measured amount of liquid ingredient for the user.

Abstract: Provided are an antibody having an improved affinity for specifically binding to BCMA, an antibody further comprising a P329G mutation, and a conjugate, a fusion, a bispecific antibody or a pharmaceutical composition comprising the antibody. In addition, further provided are a nucleic acid encoding the antibody, a host cell comprising the nucleic acid, and a method for preparing the antibody. The present invention also relates to the therapeutic and diagnostic use of the antibody binding to BCMA.

Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a Raf family kinase inhibitor and a KRAS G12C inhibitor of Formula (I), Formula (I-A) or Formula (I-B), pharmaceutical compositions comprising a therapeutically effective amounts of the inhibitors, kits comprising the compositions and methods of use therefor.

Abstract: Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Abstract: Provided is a novel active ingredient derived from locust bean and the use thereof. The present invention is a compound represented by the following formula (I) or a salt thereof, or a solvate thereof.

Abstract: A surface plasmon resonance (SPR) instrument is provided, in which light from one or more broad spectrum LEDs is sequentially passed through corresponding apertures directly into a Dove prism. Upon entering the Dove prism the light is refracted onto a surface of the prism against which an SPR sensor is attached, then internally reflects off the surface to a third surface of the Dove prism. Upon exiting the Dove prism the light is again refracted so as to be collinear with the emitted light. The light is collected by an optical fiber, passed through a filter, and conveyed to a detector. The wavelength-angle combination at which SPR occurs is found by using broad spectrum LEDs and a fixed angle. The use of apertures and the omission of collimating lenses allows a more compact SPR instrument than traditional SPR instruments.

Abstract: Techniques for using machine learning (ML) for image processing are disclosed. First encoded image data, generated by encoding a first one or more digital images using an encoder, is received. A first reconstructed one or more digital images are generated by decoding the encoded image data using a decoder corresponding to the encoder. A second reconstructed one or more digital images are generated by transforming the first reconstructed one or more digital images using a super-resolution ML model. The second reconstructed one or more digital images has a higher image resolution compared with the first reconstructed one or more digital images, and the super-resolution ML model is trained based on an image resolution corresponding to at least one of the second reconstructed one or more digital images.

Abstract: Methods of preparing polymer-filled chromatography resin and their uses are provided.

Abstract: Systems and methods for distributed ledger-based management of metadata and chain of custody of documents among financial intuitions are disclosed. In one embodiment, a method may include: (1) receiving from internal storage for the first entity, a document or file to share with a second entity; (2) at least one first entity uploading the document or file to a first entity document sharing application; (3) saving the document or file to temporary storage a distributed ledger node for the first entity, the distributed ledger node part of a distributed ledger network; (4) writing the document or file to a first entity distributed ledger; and (5) writing metadata for the document or file to the first entity distributed ledger. A second entity document sharing program may retrieve the document or file from the first entity document sharing program into a distributed ledger node for the second entity.