Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Abstract: A visual development interface may be exposed that allows developers to define, generate, and submit various computing operations for execution by a computing services provider. In some examples, the visual development interface may be employed by developers to define, generate, and submit event-triggered computing functions for execution on the computing services provider's systems. The visual development interface may allow developers to define computing operations based, at least in part, on various nodes that may represent various sub-operations or other functionality associated with a computing operation. The computing service provider may execute the computing operation using a deterministic execution engine that executes the computing operation in an organized, predictable, and reliable manner. In particular, the deterministic execution engine may employ a stage-by-stage node activation process, in which one or more associated nodes are activated in a respective stage.

Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

Abstract: A jetting device and/or fluid module includes a nozzle with a fluid outlet, a body including a fluid chamber and a fluid inlet in fluid communication with the fluid chamber, and a valve seat disposed in the fluid chamber, where the valve seat includes an opening in fluid communication with the fluid outlet. The jetting device also includes a movable element having a top portion and a bottom portion, where the top portion is disposed external to the fluid chamber and arranged to be contacted by a reciprocating drive pin, and where the bottom portion is disposed within the fluid chamber. Finally, the jetting device also includes a sealing member contacting the movable element between the top portion and the bottom portion, where the sealing member also contacts the body, and defines a portion of a boundary of the fluid chamber to seal the fluid chamber.

Abstract: A jetting device and/or fluid module includes a nozzle with a fluid outlet, a body including a fluid chamber and a fluid inlet in fluid communication with the fluid chamber, and a valve seat disposed in the fluid chamber, where the valve seat includes an opening in fluid communication with the fluid outlet. The jetting device also includes a movable element having a top portion and a bottom portion, where the top portion is disposed external to the fluid chamber and arranged to be contacted by a reciprocating drive pin, and where the bottom portion is disposed within the fluid chamber. Finally, the jetting device also includes a sealing member contacting the movable element between the top portion and the bottom portion, where the sealing member also contacts the body, and defines a portion of a boundary of the fluid chamber to seal the fluid chamber.

Abstract: The invention provides a system for providing improved placement of magnetic compression devices at a desired target site so as to create anastomoses between tissues. The system includes a targeted member or medium configured to be placed within a hollow body of a patient. The hollow body may include, but is not limited to, the stomach, gallbladder, pancreas, duodenum, small intestine, large intestine, bowel, vasculature, including veins and arteries, or the like. The targeted member or medium is configured to provide a target site at desired anatomical location within the hollow body for formation of an anastomosis between a first portion of tissue of the hollow body at the target site and a second portion of tissue of the hollow body.

Abstract: A system and method for providing torque-assist to a rotary shaft of an internal combustion engine control an electric machine in response to operation of an exhaust gas recirculation (EGR) valve to assist the rotation of the rotary shaft. The system and method facilitate periodic operation of the EGR valve to purge condensation without objectionable torque reduction when the engine is operating near full load.

Abstract: Elongate flexible medical devices can be capable of axial elongation through the mechanism of eversion or toposcopic expansion. In general, this may be accomplished by providing a flexible tubular device having a proximal end and a distal end. Retraction of the distal end in a proximal direction through the tubular body inverts the tube upon itself, causing an axial shortening of the overall length of the device. An original length of the device can be restored by coupling a pressurized media to the proximal end of the sleeve. If the distal end of the sleeve is temporarily restricted or closed, the pressurized media causes the distal end of the sleeve to travel distally until the full length of the sleeve has been restored.

Abstract: Analysis Of A Polymer A biochemical analysis system analyses polymers by taking measurements of a polymer from a sensor element comprising a nanopore during translocation of the polymer through the nanopore. When a polymer has partially translocated, the series of measurements is analysed using reference data derived from a reference sequence to provide a measure of similarity. Responsive to the measure of similarity, the sensor element may be selectively operated to eject the polymer and thereby make the nanopore available to receive a further polymer. Where the biochemical analysis system comprises an array of sensor elements and is takes measurements from sensor elements selected in a multiplexed manner, responsive to the measure of similarity, the biochemical analysis system ceases taking measurements from the currently selected sensor element and to starts taking measurements from a newly selected sensor element.

Abstract: The present invention is directed to a process for making Chloro-Substituted Nucleoside Phosphoramidate Compounds of formula (I): which are useful for the treatment and prophylaxis of HCV infection. The present invention is also directed to compounds that are useful as synthetic intermediates for making the compounds of formula (I).

Abstract: An exemplary method of providing torque-assist to a crankshaft of an internal combustion engine includes, among other things, assisting a rotation of the crankshaft using an electric machine during the transition between stages of a multi-stage forced induction system.

Abstract: A method for predicting the future operation of a vehicle is disclosed which uses stored data representative of commonly followed routes to predict the future operation of the vehicle for the current trip. By establishing that the route currently being followed is comparable to one of the commonly followed routes, information relating to that “common route” is then used to predict the future operation of the vehicle for the current trip.

Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising polymeric nanoparticles which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Abstract: Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

Abstract: The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles.

Abstract: A target sequence of polymer units is estimated from plural series of measurements taken from sequences of polymer units that comprise the target sequence or a complementary sequence. Each measurement is dependent on a k-mer (k polymer units). Models treat the measurements as observations of k-mer states, comprising transition weightings in respect of transitions between successive k-mer states and emission weightings for different measurements being observed. An estimated alignment mapping between the plural series of measurements is derived based on an application of the models to each series. An estimate of the target sequence of polymer units is generated by applying the models, treating the types of k-mer state of each model and the measurements as dimensions of a plural dimensional k-mer state and plural dimensional observations. Constraint of paths through the plural dimensional k-mer states using the derived alignment mapping greatly reduces the required processing.

Abstract: A crumber for a trencher machine is provided, the crumber including a crumber mount for mounting to a crumber boom, and a crumber arm, the crumber arm being mounted to the crumber mount by a linkage, the linkage having a first linkage arm and a second linkage arm, the linkage being arranged to allow rotation of at least one of the linkage arms of at least 75°. The crumber mount has at least one edge or surface of the crumber arm, wherein the least one edge or surface of the crumber mount and the complementary edge or surface of the crumber arm abut on each other when the crumber arm is in a lowermost position. In this manner, the crumber arm is supported along an extended length when in the lowermost position.

Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a mTOR inhibitor; and about 70 to about 99 weight percent biocompatible polymer.

Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.

Abstract: A system and method for reducing rate of increase of NOx feedgas emissions during an acceleration event in a vehicle having an engine with exhaust gas recirculation (EGR) and an electric machine, such as an integrated starter-generator (ISG) coupled to the engine include operating the electric machine to provide an assist torque and reducing engine torque accordingly in response to predicted NOx feedgas emissions exceeding a threshold. The NOx feedgas emissions may be predicted based on an exhaust gas sensor signal or a NOx model based on engine speed, engine torque, and intake EGR ratio. The engine torque may be reduced by reducing an engine torque set point. The electric machine torque may be reduced when a driver demand torque matches the reduced engine torque set point. The electric machine may be used to charge a battery in response to the driver demand torque matching the engine torque set point.