Abstract: A system and method for increasing engine heating rate to facilitate early introduction of exhaust gas recirculation after a cold start include operating an electric machine connect to the engine to apply a load to the engine. The electric machine may be operated as a generator to produce an increased engine torque demand and increase the rate of engine heating until an engine temperature and an exhaust temperature exceed corresponding thresholds. Operation of the electric machine as a generator may be stopped in response to a battery state of charge exceeding a threshold, or engine load exceeding a threshold.

Abstract: A method for preventing overheating of a diesel particulate filter during regeneration when an engine is idling may include using an electric machine to apply a load to the engine and compensating for the increase in applied load by increasing an engine torque set point to reduce the concentration of Oxygen in the exhaust gas flowing to the diesel particulate filter. Increased engine torque may be provided by adjusting air-fuel ratio by enriching an air-fuel mixture supplied to the engine and the diesel particulate filter. The control may be initiated in response to entering an idle mode during regeneration or in response to a measured or estimated temperature of the diesel particular filter exceeding a threshold or limit. Estimated temperature may be predicted using a soot combustion model.

Abstract: The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles.

Abstract: A method of removing sulfur from a lean NOx trap of a mild hybrid vehicle while the vehicle is stationary is disclosed, the method comprising connecting an electrical system of the vehicle to a large capacity external battery, operating an integrated starter generator driven by an engine of the vehicle as a generator to load the engine thereby allowing the engine to be operated at a higher torque level and rich of stoichiometric and storing the electrical energy produced by the integrated starter generator in the large capacity battery during the time period required for the removal of sulfur from the lean NOx trap.

Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.

Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.

Abstract: The present disclosure generally relates to lyophilized pharmaceutical compositions comprising a sugar, a cyclodextrin, and polymeric nanoparticles comprising a copolymer and a therapeutic agent which, upon reconstitution, have low levels of greater than 10 micron size particles. Other aspects of the invention include methods of making such nanoparticles.

Abstract: The invention relates to deployable magnetic compression devices and systems and methods for the deployment of such magnetic compression devices. The magnetic compression devices are particularly useful for creating anastomoses, e.g., in the gastrointestinal tract. The devices are especially useful for minimally-invasive delivery, e.g., using endoscopic techniques. The systems, devices, and methods can be used to treat a variety of gastrointestinal and metabolic diseases, such as diabetes, obesity, and cancer.

Abstract: A self-contained, holonomic motion tracking solution for supplementing the acquisition of inspection information on the surface of a structure, thereby enabling the real-time production of two-dimensional images from hand-held and automated scanning by holonomic-motion of non-destructive inspection (NDI) sensor units (e.g., NDI probes). The systems and methods disclosed enable precise tracking of the position and orientation of a holonomic-motion NDI sensor unit (hand-held or automated) and conversion of the acquired tracking data into encoder pulse signals for processing by a NDI scanning system.

Abstract: A system comprising a multi-functional boom subsystem integrated with a holonomic-motion boom base platform. The boom base platform may comprise: Mecanum wheels with independently controlled motors; a pair of sub-platforms coupled by a roll-axis pivot to maintain four-wheel contact with the ground surface; and twist reduction mechanisms to minimize any yaw-axis twisting torque exerted on the roll-axis pivot. A computer with motion control software may be embedded on the boom base platform. The motion control function can be integrated with a real-time tracking system. The motion control computer may have multiple platform motion control modes: (1) a path following mode in which the boom base platform matches the motion path of the surface crawler (i.e.

Abstract: A system comprising a multi-functional boom subsystem integrated with a holonomic-motion boom base platform. The boom base platform may comprise: Mecanum wheels with independently controlled motors; a pair of sub-platforms coupled by a roll-axis pivot to maintain four-wheel contact with the ground surface; and twist reduction mechanisms to minimize any yaw-axis twisting torque exerted on the roll-axis pivot. A computer with motion control software may be embedded on the boom base platform. The motion control function can be integrated with a real-time tracking system. The motion control computer may have multiple platform motion control modes: (1) a path following mode in which the boom base platform matches the motion path of the surface crawler (i.e.

Abstract: A system comprising a multi-functional boom subsystem integrated with a holonomic-motion boom base platform. The boom base platform may comprise: Mecanum wheels with independently controlled motors; a pair of sub-platforms coupled by a roll-axis pivot to maintain four-wheel contact with the ground surface; and twist reduction mechanisms to minimize any yaw-axis twisting torque exerted on the roll-axis pivot. A computer with motion control software may be embedded on the boom base platform. The motion control function can be integrated with a real-time tracking system. The motion control computer may have multiple platform motion control modes: (1) a path following mode in which the boom base platform matches the motion path of the surface crawler (i.e.

Abstract: A jetting device and/or fluid module includes a nozzle with a fluid outlet, a body including a fluid chamber and a fluid inlet in fluid communication with the fluid chamber, and a valve seat disposed in the fluid chamber, where the valve seat includes an opening in fluid communication with the fluid outlet. The jetting device also includes a movable element having a top portion and a bottom portion, where the top portion is disposed external to the fluid chamber and arranged to be contacted by a reciprocating drive pin, and where the bottom portion is disposed within the fluid chamber.

Abstract: Gastrointestinal bypass devices are described. In one embodiment, a gastrointestinal bypass device includes a liner having a proximal portion configured to be at least partially positioned in the esophagus and a distal portion configured to be at least partially positioned in the intestine. The gastrointestinal bypass device also includes a framework coupled to the proximal portion of the liner and a tissue ingrowth area formed at the proximal portion of the liner.

Abstract: The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the invention include methods of making such nanoparticles.

Abstract: A jetting device and/or fluid module includes a nozzle with a fluid outlet, a body including a fluid chamber and a fluid inlet in fluid communication with the fluid chamber, and a valve seat disposed in the fluid chamber, where the valve seat includes an opening in fluid communication with the fluid outlet. The jetting device also includes a movable element having a top portion and a bottom portion, where the top portion is disposed external to the fluid chamber and arranged to be contacted by a reciprocating drive pin, and where the bottom portion is disposed within the fluid chamber.

Abstract: A ground working tool comprises a tooth holder (70) and a replaceable tooth (30), the tooth holder (70) comprising a recess (74) for receiving at least part of a tooth (30), the recess (74) having an upper surface (80) and an opposed lower surface (78), at least one projection (92, 94) of hard material extending from the upper surface or the lower surface of the recess of the tooth holder (74), the tooth (30) comprising a distal part (32) for engaging or working the ground or earth during use and a proximal part (34), the proximal part (34) of the tooth (30) being received within the recess (74) of the tooth holder (70), the proximal part (34) of the tooth having an upper surface (33) and a lower surface (35), the tooth (30) having at least one recess (60, 62) on the upper surface or the lower surface of the proximal part thereof, the at least one recess (60, 62) being of complementary size and shape to the at least one projection (92, 94) of hard material in the recess of the tooth holder such that the at le

Abstract: The present disclosure generally relates to suspensions and compositions of polymeric nanoparticles that include docetaxel, as well as methods of treating various cancers, including refractory or drug resistant cancers in patients in need thereof using disclosed compositions.

Abstract: The present disclosure generally relates to therapeutic nanoparticles. Exemplary nanoparticles disclosed herein may include about 1 to about 20 weight percent of a vinca alkaloid; and about 50 to about 99 weight percent biocompatible polymer.

Abstract: Modular devices for jetting a fluid material and components for modular jetting devices. The devices may include a pressurized air or positive displacement pump fluid supply module to supply a fluid module inlet. A syringe may feed material through a check valve to a positive displacement pump, which feeds material through another check valve to the fluid module. Inside the fluid module is a valve element moved to contact a valve seat and jet a droplet of material by contact between an external drive pin and a movable element of the fluid module. Either a piezoelectric actuator, a pneumatic actuator, or another actuator may move the drive pin. A controller may coordinate the supply of fluid from the positive displacement pump with the rate at which material is jetted. The fluid module and positive displacement pump are easily removable from the jetting device.