Abstract: The invention relates to a method for obtaining APRIL-binding peptides. With this method APRIL-binding peptides may be obtained and/or selected. Further aspects of the invention relate to a cell comprising a nucleotide sequence coding for an APRIL-binding peptide according to the invention, a process for producing an APRIL-binding peptide and the APRIL-binding peptide obtainable in the production process and/or the selection method. In view of the possible utility of the APRIL-binding peptides according to the invention, further aspects of the invention relate to diagnostic uses of an APRIL binding peptide of the invention.

Abstract: Disclosed herein are voltage driver circuits and methods of operating the same. In some embodiments, a plurality of circuit slices are provided in a voltage driver circuit, each circuit slice has a time constant, and is controlled to switchably connect a driver output to either a high voltage level or a low voltage level, or to disconnect the driver output from both voltage levels. The circuit slices may provide an adjustable output impedance, which may be set to match the impedance of different loads. The circuit slices may also provide adjustable voltages with low power consumption, particularly in high speed applications. The circuit slices may also have programmable capacitors that may be adjusted to provide a programmable time domain behavior of the output voltage waveform, such as a programmable voltage peaking characteristic.

Abstract: A quetiapine fumarate composition for oral administration is provided comprising a pharmaceutically acceptable salt or solvate of quetiapine existing as a suspension in an aqueous carrier agent. The inventive liquid formulation demonstrates high bioavailability consistent with approved dosage forms, low agglomeration, reduced content of excipients commonly used in solid oral dosage forms and extended shelf life stability. Also provided is a method of manufacturing a liquid quetiapine suspension composition for oral administration and methods of administering therapeutically effective dosages of an oral liquid quetiapine suspension composition to patients in need thereof.

Abstract: A method for producing polymer coated steel sheet for 3-piece cans and 3-piece cans produced thereof.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: The invention relates to a method for obtaining APRIL-binding peptides. With this method APRIL-binding peptides may be obtained and/or selected. Further aspects of the invention relate to a cell comprising a nucleotide sequence coding for an APRIL-binding peptide according to the invention, a process for producing an APRIL-binding peptide and the APRIL-binding peptide obtainable in the production process and/or the selection method. In view of the possible utility of the APRIL-binding peptides according to the invention, further aspects of the invention relate to diagnostic uses of an APRIL binding peptide of the invention.

Abstract: An example one-shot circuit includes: circuitry including a set-reset (SR) latch to produce an output pulse of controlled duration in response to an input signal rising edge, where the SR latch includes a first circuit input and a second circuit input; a circuit path to provide a signal to the first circuit input; and a delay element connected to the circuit path and to the second circuit input.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: Disclosed herein are voltage driver circuits and methods of operating the same to provide a variable output voltage that is suitable for use in ATE to provide a large number of test signals with accurate voltage levels at high data rates using components that consume relatively low power. According to an aspect, a change in output current in a voltage driver related to changing output voltage may be offset by a stabilization current generated by a correction driver for the voltage driver, such that supply currents drawn from the supply voltages can remain substantially stable. The correction driver may be connected to one or more supply voltages, and programmed to output a stabilization current that offsets changes in supply currents arising from changing of the programmed output of the voltage driver circuit. Such a driver may enable a test system to more precisely test semiconductor devices.

Abstract: A polymer film for laminating onto a metal substrate (M), the polymer film including an adhesion layer (A) and a bulk layer (B), wherein the adhesion layer is intended for bonding to the metal substrate and includes 20 to 50 wt. % of a non-crystallisable copolyester, 50 to 80 wt. % of polybutylene terephthalate (PBT) and 0-10 wt. % of polymers and additives, and wherein the bulk layer consists of is at least 91 wt. % of PBT and at most 9% of other polymers and additives.

Abstract: A process for producing a laminate in a coating line including the subsequent steps of: —providing a metal strip; —pre-heating the metal strip to a temperature of at least 100° C.; —producing a laminate by adhering a first thermoplastic polymer coating layer on one major surface of the strip and a second thermoplastic polymer coating layer on the other major surface of the strip wherein the first thermoplastic polymer coating layer includes a polymer with a melting point below 200° C.; —heating the laminate in a non-oxidising gas atmosphere in a post-heating step to at least the melting point of the polymer or polymers in the second polymer coating layer, and at least 220° C.; —rapidly cooling or quenching the laminate to a temperature of below 50° C. Also, a polymer coated metal strip produced thereby, or a can produced therefrom.

Abstract: Circuitry and methods of operating the same to delay a signal by a precise and variable amount. One embodiment is directed to a high speed delay line used in automated test equipment. The inventors have recognized and appreciated that an input signal having high data rate may be split into parallel split signals having lower data rates that are delayed in respective parallel delay paths before being combined to generate a delayed signal. One advantage of delaying a signal in such a fashion is to provide high delay line timing accuracy at high data speeds, while using a compact circuit design using circuitry components of lower bandwidth with reduced power consumption, for example by using complementary metal-oxide-semiconductor (CMOS). A further advantage is that a high speed delay line may be constructed from multiple lower data rate parallel delay lines that are modular, simplifying circuit design.

Abstract: Disclosed herein are voltage driver circuits and methods of operating the same to provide a variable output voltage that is suitable for use in ATE to provide a large number of test signals with accurate voltage levels at high data rates using components that consume relatively low power. According to an aspect, a change in output current in a voltage driver related to changing output voltage may be offset by a stabilization current generated by a correction driver for the voltage driver, such that supply currents drawn from the supply voltages can remain substantially stable. The correction driver may be connected to one or more supply voltages, and programmed to output a stabilization current that offsets changes in supply currents arising from changing of the programmed output of the voltage driver circuit. Such a driver may enable a test system to more precisely test semiconductor devices.

Abstract: Disclosed herein are voltage driver circuits and methods of operating the same. In some embodiments, a plurality of circuit slices are provided in a voltage driver circuit, each circuit slice has a time constant, and is controlled to switchably connect a driver output to either a high voltage level or a low voltage level, or to disconnect the driver output from both voltage levels. The circuit slices may provide an adjustable output impedance, which may be set to match the impedance of different loads. The circuit slices may also provide adjustable voltages with low power consumption, particularly in high speed applications. The circuit slices may also have programmable capacitors that may be adjusted to provide a programmable time domain behavior of the output voltage waveform, such as a programmable voltage peaking characteristic.

Abstract: Disclosed herein are voltage driver circuits and methods of operating the same. In some embodiments, a plurality of circuit slices are provided in a voltage driver circuit, each circuit slice is controlled to switchably connect a driver output to either a high voltage level or a low voltage level via a resistor, or to disconnect the driver output from both voltage levels. The circuit slices may provide an adjustable output impedance, which may be set to match the impedance of different loads. The circuit slices may also provide adjustable voltages with low power consumption, particularly in high speed applications. A calibration procedure is disclosed herein to generate a lookup table for how to selectively connect circuit slices to supply voltages given a target output voltage.

Abstract: A multi-band, multi-mode software defined radio (MBMM SDR) platform having a multi-band front end (MBFE), a multi-mode digital radio (MMDR), a configuration & control (C2) subsystem, and a power distribution subsystem. The MBFE provides wideband operations, L/S/C-Band telemetry band selection, and channel tuning. The MMDR provides high-speed signal processing and flexible programming to support multiple telemetry waveforms that are implemented using system-on-chip technology. An integrated pulse code modulation/frequency modulation (PCM/FM) and shaped offset quadrature shift keying (SOQPSK-TG) transmitter and a non-coherent PCM/FM receiver has been developed. The C2 subsystem allows for pre-test configuration and control of the MBFE and MMDR subsystems.

Abstract: A process for laminating a polyester film onto a major surface of a metal strip and to a laminated metal strip produced thereby, or a can produced therefrom.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.

Abstract: Disclosed herein is a method for capturing a dental object with an object volume, in particular, at least one part of a maxilla and/or a mandible, with the sue of an MRT apparatus. A plurality of MRT segment images, which depict the defined segmented volume regions are acquired by an MRT apparatus within a measurement volume of the MRT apparatus. The segmented volume regions overlap no more than partially. In this case a target surface is defined or has already been defined. Then a two dimensional composite image, which corresponds to a two dimensional aggregate image through the target surface within the object volume of the dental object, is generated computer-aided from the individual MRT segment images.

Abstract: The invention relates to APRIL-binding antibodies, which bind the same epitope of human APRIL as an antibody having an antigen binding site of hAPRIL.01A. The antibodies of the present invention comprise specific selections of framework sequences of the VH and VL domains and have unexpected features in comparison to hAPRIL.01A. The invention further relates to compositions comprising an antibody of the invention and to the medical and diagnostic uses of the antibodies and compositions.