Abstract: A stent graft delivery device that is pre-loaded with a single guide wire for both tracking the device within a main vessel as well as for cannulating one or more branch vessels is described. The delivery device comprises a delivery catheter having a prosthesis releasably secured thereto and a nose cone extending from the proximal end of the catheter. In a delivery configuration, a secondary catheter is coaxial with the guide wire and extends through at least a portion of the prosthesis lumen and is held within a channel formed in the nose cone. In a released configuration, secondary catheter and guide wire are retracted distally out of the channel formed in the sidewall of the nose cone dilator and can be manipulated for cannulating a branch vessel.

Abstract: A controlled expansion stent graft delivery system has an adjustment configuration in which a retractable sheath is at a retracted position out of contact with a stent graft, but expansion of the stent graft is controlled by a control tether, which has a middle segment wrapped around a fabric tube of the stent graft. The stent graft changes diameter responsive to a tension level in the control tether. At least one of an orientation and a position of the stent graft may be adjusted during controlled expansion via the control tether.

Abstract: A controlled expansion stent graft delivery system has an adjustment configuration in which a retractable sheath is at a retracted position out of contact with a stent graft, but expansion of the stent graft is controlled by a control tether, which has a middle segment wrapped around a fabric tube of the stent graft. The stent graft changes diameter responsive to a tension level in the control tether. At least one of an orientation and a position of the stent graft may be adjusted during controlled expansion via the control tether.

Abstract: In one aspect of the invention, a preloaded stent graft delivery device including a guidewire catheter having a proximal end, a distal end, and a guide wire lumen therethrough; a nose cone dilator at the proximal end of the guide wire catheter; a handle assembly at the distal end of the guidewire catheter; a thumbwheel rotatably mounted to the handle assembly, the thumbwheel having a ratchet assembly disposed therein; a sheath mount positioned within an interior surface of the handle assembly and coupled to the thumbwheel; a pusher catheter extending from the handle assembly towards the nose cone dilator, the pusher catheter comprising at least one lumen therethrough where the guidewire catheter extends through the at least one lumen within the pusher catheter; a sheath disposed coaxially over the pusher catheter, the sheath at least partially coupled to the sheath mount within the interior surface of the handle assembly.

Abstract: The present embodiments describe an endograft having at least two branches extending from two fenestrations on the endograft body, and methods for deploying the same. In one example, the system comprises one internal branch that is relatively straight, and one external branch that is helically curved. The fenestrations may be circumferentially located on substantially the same side of the endograft main body, and distal regions of the branches may be circumferentially located on substantially opposite sides of the main body. The branches may be longitudinally non-overlapping. Connection stents may be configured to extend from the branches to provide fluid communication with peripheral vessels. Peripheral vessels may include the coronary or renal arteries. In another example, the branches are both external to the main endograft body.

Abstract: A graft having a tubular body having a first end configured for attachment to a first vessel having a first compliance and second end configured for attachment to a second vessel having a second compliance different from the first compliance, and having a plurality of compressible chambers in the wall of the tubular body in which the chamber adjacent the first end of the tubular body is less compressible than the chamber adjacent the second end of the tubular body such that first end of the tubular body substantially matches the first compliance and the second end of the tubular body substantially matches the second compliance.

Abstract: A graft for inducing helical blood flow, including a tubular body with fluid inflow and fluid outflow ends, and with inner and outer sidewalls. A lumen extends between the fluid inflow end and fluid outflow end. A compressible chamber is disposed between the outer sidewall and the inner sidewall. The compressible chamber has an incompressible seam that follows a substantially helical path around a longitudinal axis of the tubular body. When internal (e.g., blood) pressure increases on the inner sidewall, a vane element is formed that follows the substantially helical path around the longitudinal axis of the tubular body. The vane element may induce helical blood flow. The width of the compressible chamber may decrease in a compressed state (e.g., systole). The chamber may be filled with a predetermined amount of at least one of a gas, liquid, or vapor. The graft may have a second incompressible seam/vane.

Abstract: Systems and techniques for positioning radiopaque markings on medical stent devices are provided. Specific combinations of adjacent radiopaque markings and overlapping radiopaque markings on the stent devices are presented to provide specific feedback information to an administrator working to guide the stent devices through vessels.

Abstract: A stent graft assembly having a tubular body and a constraining patch attached to the interior surface of the tubular body. The constraining patch delineates a small passageway close to the inner surface of the tubular body. A cannula may extend through the passageway.

Abstract: A prosthesis delivery device comprises a proximal end and a distal end, a prosthesis retention section at the proximal end, and a prosthesis retained on the prosthesis retention section. The prosthesis has a proximal end releasably attached at the prosthesis retention section and a distal end releasably attached at the prosthesis retention section. A sheath is slidably disposed over the prosthesis. A delivery handle near the distal end the delivery device comprises a rotatable inner cannula having a cannula lumen and cannula handle. The cannula handle is rotatable with the inner cannula. Further, a positioner handle is releasably engaged with the cannula handle. Rotation of the inner cannula releases the proximal end of the prosthesis from the delivery device and withdrawal of the sheath from over the prosthesis releases the distal end of the prosthesis from the delivery device.

Abstract: Disclosed herein is a stent graft device with improved visualization characteristics and a method for making such a device. The device includes a plurality of radiopaque rings and associated structures, which are folded in a predictable fashion prior to crimping. In some embodiments, a mandrel for biasing the end rings of a ringed structure is utilized. In other embodiments, a biodegradable adhesive is used to assist in folding.

Abstract: An occlusion device for occluding a body vessel and methods of using the device are disclosed.

Abstract: A vascular pulsation device may be provided including a pulsation portion and a reservoir portion. The pulsation portion may be insertable into a bodily passageway and may include an expandable segment, a first end, and a second end. The reservoir portion may be in fluid connection with the pulsation portion by a supply passage and a return passage. An opening of the supply passage may be positioned proximate to the second end of the pulsation portion. An opening of the return passage may be positioned proximate to the first end of the pulsation portion.

Abstract: A magnetic field device for directing a magnetic coupling source includes an electrical power source, a control module, a muzzle, and an electromagnet adjacent the muzzle and connected to the electrical power source. A magnetic sensor within the muzzle is adjacent to the electromagnet. A magnet loading chamber is adjacent to the electromagnet magnetic and opposite to the magnetic sensor. The magnet loading chamber is configured to accommodate one or more permanent magnets. A magnetic shield surrounds exterior surfaces of the electromagnet and magnet loading chamber. A user operable control device is electrically connected to the electromagnet and to the electrical power source. The control device regulates an amount of electric current from the electrical power source to the electromagnet. A magnet guidewire delivery system includes a guide wire having a magnetic element and a magnetic field device generating a magnetic field that couples with the magnetic element.

Abstract: A stent graft includes a fabric tube supported by and attached to a stent. A plurality of streamers are attached at one end to an outer surface of the fabric tube and have an unattached coagulant end that is free to move with respect to the fabric tube within a sac of an aneurism to promote coagulation of blood, such as to inhibit Type II endoleaks. Each of the streamers have a length dimension that is greater than both a width dimension and thickness dimension. The streamers may comprise at least one of a extracellular matrix material, a hydrogel and embolic fibers.

Abstract: A pre-loaded stent graft delivery device having a guide wire catheter and a handle including a multi-port manifold with access ports, where an access sheath extends from each access port. A sheath is disposed coaxially around the guide wire catheter and includes two splits that enable the retraction of the sheath while the access sheaths are disposed within the respective access port of the manifold.

Abstract: A prosthesis for placement within an aortic root, includes a graft having a proximal end, distal end, and lumen disposed therethrough and a stent assembly disposed at that proximal end of the graft, the stent assembly comprising a first stent unit comprising a first proximal section having a first bend interconnected by a first curved strut and a second curved strut and a second bend interconnected by a third curved strut and a fourth curved strut, the first bend of the first proximal section and second bend of the first proximal section facing each other and circumferentially spaced apart; and a first distal section connected to the first proximal section.

Abstract: An endovascular prosthesis and method of constructing a prosthesis device for implantation into the lumen of a body vessel. The endovascular prosthesis includes a fenestration in the device surrounded by an inner edge, and the inner edge further surrounded by an outer edge of larger diameter. A shaped protrusion of semi-rigid graft material spans the distance between the inner edge and the outer edge connecting the two edges. The shape protrusion has a surface area larger than the plane of the tubular body between the edges and therefore will have excess material. This excess material allows the inner edge and the fenestration to move within the circumference of the outer edge. The shaped protrusion may also form a semi-rigid dome.

Abstract: A stent is provided having a plurality of intersecting elongated members arranged to form a plurality of cells, the plurality of cells defining an elongated tube with a lumen running therethrough. The elongated tube has first, second, and third sections, the first section having a substantially first diameter and the third section having a substantially constant second diameter that is larger than the substantially constant first diameter of the first section, wherein the diameter of the second section transitions from the first diameter to the second diameter. Each of the plurality of cells within the first section have a pitch that is tighter than each of the plurality of cells within the second and third sections. In the second section, the plurality of intersecting elongated members includes a plurality of pairs of elongated members, wherein each pair of elongated members includes two adjacent elongated members twisted axially around each other.

Abstract: A stent is provided having a plurality of intersecting elongated members arranged to form a plurality of cells, which define an elongated tube with a lumen. The elongated tube has first and second sections, the first section having a substantially constant first diameter, the second section having a substantially constant second diameter that is larger than the first diameter. The elongated tube also has a transition section between the first and second sections, the transition section having a concave curvature extending proximally from the first section and a convex curvature extending proximally from the concave curvature to the second portion. A proximal end of the second section has a plurality of rounded ends formed by the plurality of intersecting elongated members. Each of the plurality of cells within the first section have a pitch that is tighter than each of the plurality of cells within the second section.