Abstract: This discloses a device for closure of an opening in a medical patient's subcutaneous tissue wall. The devices disclosed included a catheter having one or more inflatable, bio-degradable balloon and one or more sheets of ECM material loaded on and around said catheter. Upon inflation of the one or more balloons the sheet(s) of ECM material are held against the tissue wall by the balloon(s). Surgical methods using the device are also disclosed.

Abstract: The present embodiments provide systems and methods for deploying at least a portion of a stent. In one embodiment, the system comprises a cannula having an outer surface, and a coiled member having proximal and distal ends and a plurality of turns disposed therebetween. At least a portion of the coiled member is secured to the outer surface of the cannula. A stent is releasably secured to a portion of the coiled member. A protective cage may encircle the coiled member.

Abstract: The present embodiments provide systems and methods for deploying at least a portion of a stent. In one embodiment, the system comprises a cannula having an outer surface, and at least one coiled member having proximal and distal ends and a plurality of turns disposed therebetween. One of the proximal and distal ends of the coiled member is secured to the outer surface of the cannula, and the other of the proximal and distal ends of the coiled member is unsecured relative to the outer surface of the cannula. A portion of a stent is looped around the unsecured end of the coiled member and disposed within spacing between adjacent turns of the coiled member. Rotation of the cannula subsequently causes the portion of the stent to disengage from the coiled member.

Abstract: A stent graft for use in a medical procedure to treat a dissection of a patient's ascending thoracic aorta. The stent graft includes bare alignment stents at least at a proximal end, and often with a stent at both ends, each stent having opposing sets of curved apices, where the curved section of one broader set of apices has a radius of curvature that is greater than the curved section of the other narrower set of apices. The proximal stent is flared in a manner such that its broad apices occupy a larger circumference around the stent than do its narrower apices, where this flared feature provides for anchoring engagement near the aortic root in a manner not interfering with the coronary arteries or the aortic valve.

Abstract: An aortic stent-graft may include a tubular graft extending from a proximal end to a distal end, the graft comprising a proximal sealing portion and an intermediate portion, wherein a proximal end of the intermediate portion abuts the distal end of the proximal sealing portion. At least one sealing stent may be attached to the proximal sealing portion. A first fenestration window is disposed in the intermediate portion. The first fenestration window has a length determined by the equation L=1.23*D?24 millimeters, where L is the length of the first fenestration window. D is between about 24 millimeters and 45 millimeters.

Abstract: A woven fabric for a low profile implantable medical device includes a plurality of textile strands of a composite yarn aligned in a first direction interlaced with a plurality of textile strands of the composite yarn aligned in a second direction. The composite yarn includes a combination of a first material and a second material. The textile strands have a size between about 10 denier to about 20 denier. The first material has at least one characteristic different from the second material and the second material reacts favorably with blood when placed within an artery.

Abstract: A delivery system may include a stent-graft, a locking member, and one or more diameter reducing members. The stent-graft may include a tubular graft comprising first and second longitudinally extending sides disposed opposite each other and connected at a tangent line. When the locking member is in a locked position, the locking member restrains a surface of the graft against the cannula. The first diameter reducing member may be slidably connected to a first portion of the graft that is disposed proximate the tangent line and may be slidably connected to a second portion of the graft that is spaced circumferentially away from the tangent line. When the first diameter reducing member is in a restrained position, the second portion of the graft is drawn toward the first portion of the graft and the proximal portion of the stent-graft has a reduced diameter configuration with at least two lobes.

Abstract: An endoluminal prosthesis is described and comprises a stent (40), At least one barb (42) secured to the stent, and a degradable barb guard (52) covering at least a portion of the barb and protecting the distal tip when the stent is in a compressed configuration. The barb guard (52) comprises a degradable structure that degrades to expose the distal tip of the barb when the stent is placed in a vessel.

Abstract: An endoluminal device for repairing an aortic dissection and preventing future aortic dissections, the device including a plurality of struts with at least one of the plurality of struts having a mid-strut portion having two or more secondary struts, the device being configured to be secured within a false lumen of the aorta and contain filler material in order to encourage thrombosis within the false lumen.

Abstract: A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter-reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter-reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

Abstract: A stent for use in a medical procedure having opposing sets of curved apices, where the curved section of one set of apices has a radius of curvature that is greater than the curved section of the other set of apices. One or more such stents may be attached to a graft material for use in endovascular treatment of, for example, aneurysm, thoracic dissection, or other body vessel condition.

Abstract: A stent graft for use in a medical procedure to treat a dissection of a patient's ascending thoracic aorta. The stent graft includes bare alignment stents at least at a proximal end, and often with a stent at both ends, each stent having opposing sets of curved apices, where the curved section of one broader set of apices has a radius of curvature that is greater than the curved section of the other narrower set of apices. The proximal stent is flared in a manner such that its broad apices occupy a larger circumference around the stent than do its narrower apices, where this flared feature provides for anchoring engagement near the aortic root in a manner not interfering with the coronary arteries or the aortic valve.