Abstract: The present embodiments provide an endoluminal prosthesis deployment system and method for deploying the prosthesis for cannulation of branch vessels. The prosthesis includes an anterior fenestration and a posterior opening. A guide is disposed to exit the prosthesis lumen through a lateral fenestration, enter through the anterior fenestration, and exit the prosthesis lumen through the posterior opening. A sheath can be preloaded over the branch wire at the lateral fenestration for vessel cannulation, such as in renal arteries. The sheath can include another branch wire that extends from the lateral fenestration to another lateral fenestration. An end of the guide is retracted after partial expansion of the prosthesis, and another sheath is inserted over the retracted guide and moved through the posterior opening and to the anterior fenestration. A separate branch guide wire is then directed through the sheath for vessel cannulation, such as the SMA.

Abstract: An occlusion device for occluding a body vessel and methods of using the device are disclosed.

Abstract: A stent graft assembly having a tubular body and a constraining patch attached to the interior surface of the tubular body. The constraining patch delineates a small passageway close to the inner surface of the tubular body. A cannula may extend through the passageway.

Abstract: The present disclosure relates to an apparatus and method for deployment of a modular stent-graft system. In one embodiment, a modular system comprises a first stent graft having a tapered zone, a second stent graft configured for insertion within the first stent graft, the second stent graft comprising a tapered zone, wherein each tapered zone has an angle of taper and the angle of taper of the tapered zone of the second stent graft is substantially the same as the angle of taper of the tapered zone of the first stent graft, and wherein when the second stent graft is disposed within the first stent graft, the tapered zone of the second stent graft conforms precisely to the tapered zone of the first stent graft.

Abstract: A controlled expansion stent graft delivery system has an adjustment configuration in which a retractable sheath is at a retracted position out of contact with a stent graft, but expansion of the stent graft is controlled by a control tether, which has a middle segment wrapped around a fabric tube of the stent graft. The stent graft changes diameter responsive to a tension level in the control tether. At least one of an orientation and a position of the stent graft may be adjusted during controlled expansion via the control tether.

Abstract: The disclosure relates to medical devices comprising coaxial cannulae. A medical device includes an outer cannula and a coaxial inner cannula that is secure to the inner cannula. The circumferential wall of one of the cannulae defines a pattern of openings that extends along a spiral path about the lengthwise axis of the cannula.

Abstract: An aortic stent-graft may include a tubular graft extending from a proximal end to a distal end, the graft comprising a proximal sealing portion and an intermediate portion, wherein a proximal end of the intermediate portion abuts the distal end of the proximal sealing portion. At least one sealing stent may be attached to the proximal sealing portion. A first fenestration window is disposed in the intermediate portion. The first fenestration window has a length determined by the equation L=1.23*D?24 millimeters, where L is the length of the first fenestration window. D is between about 24 millimeters and 45 millimeters.

Abstract: A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter-reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter-reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

Abstract: An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end.

Abstract: A stent graft (40) for treating Type-A dissections in the ascending aorta (22) is provided with a plurality of diameter reducing suture loops (56-60) operable to constrain the stent graft during deployment thereof in a patient's aorta. The diameter reducing loops (56-60) allow the stent graft (40) to be partially deployed, in such a manner that its location can be precisely adjusted in the patient's lumen. In this manner, the stent graft can be placed just by the coronary arteries (26, 28) with confidence that these will not be blocked. The stent graft (40) is also provided with proximal and distal bare stents (44,52) for anchoring purposes.

Abstract: The present embodiments describe an endograft having at least two branches extending from two fenestrations on the endograft body, and methods for deploying the same. In one example, the system comprises one internal branch that is relatively straight, and one external branch that is helically curved. The fenestrations may be circumferentially located on substantially the same side of the endograft main body, and distal regions of the branches may be circumferentially located on substantially opposite sides of the main body. The branches may be longitudinally non-overlapping. Connection stents may be configured to extend from the branches to provide fluid communication with peripheral vessels. Peripheral vessels may include the coronary or renal arteries. In another example, the branches are both external to the main endograft body.

Abstract: A stent-graft comprises a substantially tubular graft material, and a stent coupled to the graft material. The stent has proximal and distal ends and further has compressed and deployed states. The proximal end is disposed proximally beyond a proximal edge of the graft material, and the distal end has at least one portion overlapping with the proximal edge of the graft material. In one example, the stent comprises at least one distal apex having a bifurcation extending into first and second leg regions. A distal end of the first leg region is positioned to overlap the graft material at a location circumferentially spaced apart from a location at which a distal end of the second leg region overlaps the graft material in the deployed state.

Abstract: An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. A second stent may be positioned adjacent to and distal of the first stent. An opening in the sidewall may be positioned longitudinally between a peak of the first stent and a valley of the second stent. A tubular branch may be disposed in the opening. The branch may include first and second end openings. The branch may be flexibly orientable between a retrograde configuration in which the first end opening is oriented toward the distal end and the second end opening is oriented toward the proximal end and an antegrade configuration in which the first end opening is oriented toward the proximal end and the second end opening is oriented toward the distal end.

Abstract: A handle assembly for a prosthesis delivery device is described. The handle assembly comprises a stationary main handle having a proximal end and a distal end and an outer surface extending there between. A first handle extends proximally from the main handle and is rotationally moveable relative to the main handle, the first handle having a proximal end and a distal end and defining a first handle interior. A second handle extends distally from the main handle and is rotationally moveable relative to the main handle, the second handle having a proximal end and a distal end and defining a second handle interior. The first handle comprises a threaded internal surface extending between the proximal and distal ends and the second handle comprises a threaded internal surface extending between the proximal and distal ends.

Abstract: An endovascular prosthesis and method of constructing said prosthesis device for implantation into the lumen of a body vessel. The endovascular prosthesis comprises a fenestration in the device surrounded by an inner edge, and the inner edge further surrounded by an outer edge of larger diameter. A shaped protrusion of semi-rigid graft material spans the distance between the inner edge and the outer edge connecting the two edges. The shape protrusion has a surface area larger than the plane of the tubular body between the edges and therefore will have excess material. This excess material allows the inner edge and the fenestration to move within the circumference of the outer edge. The shaped protrusion may also form a semi-rigid dome.

Abstract: An endovascular assembly for improving vessel compliance by reducing the blood pressure needed to eject a given volume of blood. The assembly comprises a first expandable container, a balloon for example, positioned in the vascular system. The first container has a variable volume in response to blood flow in the vessel, and is fixed to at least one expandable attachment member. When the attachment member is expanded inside of the vasculature, the attachment member is preferably fixed inside the vessel. The assembly further comprises a second container, preferably having a fixed volume that forms a closed fluid system when fluidly connected to the first container. The connection between the first and second container permits a change in volume in the first container to flow fluid into the second container. The second container can be placed in a different location inside of the patient, preferably outside of the vessel.

Abstract: A prosthesis delivery device comprises a proximal end and a distal end, a prosthesis retention section at the proximal end, and a prosthesis retained on the prosthesis retention section. The prosthesis has a proximal end releasably attached at the prosthesis retention section and a distal end releasably attached at the prosthesis retention section. A sheath is slidably disposed over the prosthesis. A delivery handle near the distal end the delivery device comprises a rotatable inner cannula having a cannula lumen and cannula handle. The cannula handle is rotatable with the inner cannula. Further, a positioner handle is releasably engaged with the cannula handle. Rotation of the inner cannula releases the proximal end of the prosthesis from the delivery device and withdrawal of the sheath from over the prosthesis releases the distal end of the prosthesis from the delivery device.

Abstract: A stent for use in a medical procedure having opposing sets of curved apices, where the curved section of one set of apices has a radius of curvature that is greater than the curved section of the other set of apices. One or more such stents may be attached to a graft material for use in endovascular treatment of, for example, aneurysm, thoracic dissection, or other body vessel condition.

Abstract: A prosthesis delivery device comprises a proximal end and a distal end, a prosthesis retention section at the proximal end, and a prosthesis retained on the prosthesis retention section. The prosthesis has a proximal end releasably attached at the prosthesis retention section and a distal end releasably attached at the prosthesis retention section. A sheath is slidably disposed over the prosthesis. A delivery handle near the distal end the delivery device comprises a rotatable inner cannula having a cannula lumen and cannula handle. The cannula handle is rotatable with the inner cannula. Further, a positioner handle is releasably engaged with the cannula handle. Rotation of the inner cannula releases the proximal end of the prosthesis from the delivery device and withdrawal of the sheath from over the prosthesis releases the distal end of the prosthesis from the delivery device.

Abstract: A stent graft delivery device that is pre-loaded with a single guide wire for both tracking the device within a main vessel as well as for cannulating one or more branch vessels is described. The delivery device comprises a delivery catheter having a prosthesis releasably secured thereto and a nose cone extending from the proximal end of the catheter. In a delivery configuration, a secondary catheter is coaxial with the guide wire and extends through at least a portion of the prosthesis lumen and is held within a channel formed in the nose cone. In a released configuration, secondary catheter and guide wire are retracted distally out of the channel formed in the sidewall of the nose cone dilator and can be manipulated for cannulating a branch vessel.