Abstract: Disclosed are compounds, compositions and methods for inhi.beta.iting interleukin-1.beta. protease activity, the compounds .alpha.-substituted methyl ketones having the formula (I) set forth herein. These compounds are inhibitors of IL-1.beta. converting enzyme and as such are useful as therapeutic agents for certain infectious diseases.

Abstract: Disclosed are compounds, compositions and methods for inhibiting interleukin -1.beta. protease activity, the compounds having the structure of formula (1) as described in the specification.

Abstract: Compounds which Inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is Independently L-valine or L-alanine;R.sub.1 is selected from the group consisting of N-?4(N,N-dimethylaminomethyl)!benzoyl, N-benzoyloxycarbonyl, N-methyl-N-?4-(pyridyl)methyl!, N-?4-(pyddyl)methyl!carbonyl, N-3-(piperidinopropionyl), N-?4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyddyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-?2-(4-pyridyl)ethyl!carbonyl, and N-(N-phenylpiperazino) carbonyl; andR.sub.8, R.sub.9 and R.sub.10 are as defined below.

Abstract: Compounds which inhibit interleukin-1.beta. protease activity, pharmaceutical compositions containing the compounds and methods using the compounds are provided. The compounds have the formula ##STR1## wherein n is 0-2; each AA is independently L-valine or L-alanine; R.sub.1 is selected from the group consisting of N-[4-(N,N-dimethylaminomethyl)]benzoyl, N-benzyloxycarbonyl, N-methyl-N-[4-(pyridyl)methyl], N-[4-(pyridyl)methyl]carbonyl, N-3-(piperidinopropionyl), N-[4-(morpholinoethoxy)benzoyl, N-2-(quinuclidinyl)carbonyl, N-(3-pyridyl)methoxy carbonyl, N-(2-pyridyl)methoxy carbonyl, N-methyl-N-benzyl carbonyl, N-methyl-N-[2-(4-pyridyl)ethyl]carbonyl, and N-(N-phenylpiperazino)carbonyl; and R.sub.8, R.sub.9, R.sub.10 are each independently hydrogen, lower alkyl, halo substituted methyl, carbalkoxy, benzyl, phenyl, or phenyl mono or disubstituted with fluoro, nitro, methoxy, chloro, trifluoromethyl or methanesulfonyl.

Abstract: The reactivity of a neutron chain reaction in a nuclear reactor is automatically reduced upon failure of the coolant flow by a system in which nuclear-fuel particles are suspended against gravitational forces by forces of the coolant flow and are in the reactive zone when so suspended. Upon failure of the coolant flow, the particles settle into a space outside the reactive zone and thus do not contribute to the neutron chain reaction and reactivity is reduced.

Abstract: Azole-fused peptides useful as Substance P antagonists and analgesics, for example ##STR1## wherein ##STR2## represents ##STR3## wherein X is O, S or NH and * is D, or as intermediates therefor are prepared by azole and peptide forming methods.

Abstract: Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH.sub.2 R.sup.1 has the R-configuration, the carbon atom bearing CH.sub.2 R.sup.2 has the S-configuration, R.sup.1 is isopropyl, R.sup.2 is 3-indolyl, m is 2, n is 0, p is 2 and R.sup.3 and R.sup.4 taken alone are each methyl or R.sup.3 and R.sup.4 taken together with N are morpholino and pharmaceutically acceptable acid addition salts or solvates or acid addition salts-solvates thereof, which are matrix-metalloprotease inhibitors useful in treatment of disease in which matrix-metalloprotease promoted connective tissue remodelling is a causative factor, for example, rheumatoid arthritis and cancer, and a method of preparation and method of use thereof and methods of preparation of intermediates therefor are disclosed.

Abstract: High temperature reactor with residual-heat transfer system comprises a cooling gas intake at the bottom and cooling gas outlet at the top so that a cooling gas can flow from the bottom to the top through the reactor core. In order to assure reliable heat transfer a bypass duct is provided with a lower end communicating with the cooling gas intake and the upper end communicating with the cooling gas outlet. The bypass duct is arranged parallel to the reactor core and passing a partial flow of cooling gas from the bottom to the top. This partial flow of cooling gas heats up only trivially. This partial flow of cooling gas is further cooled by the cooler. The upward flow of the comparatively cold cooling gas in the bypass duct stops and by itself reverses because the cooling gas in the bypass duct is drawn toward the reactor core on account of the natural convection.

Abstract: Di(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides useful as Substance P agonists and/or antagonists and as antihypertensives and/or analgesics and a process for preparing them are disclosed.

Abstract: A core energy plant with closed working gas circuit, in which within an or safety container there are arranged a reactor core of pre-stressed concrete for heating the working gas, a working gas driven turbo-set with generator, and other components of the working gas circuit such as heat exchanger and gas storage means. The reactor core is separated from the turbo-set and other components and is arranged in a separate reactor chamber with walls of pre-stressed concrete, while the other components are respectively arranged in separate chambers, within an inner concrete container which has chambers for receiving the turbo-set with generator and the remaining components of the working gas circuit and which has its outer wall arranged adjacent the vertical inner wall of the outer safety container there is provided a recess for a pre-stressed concrete container for receiving the reactor core.

Abstract: A gas-cooled nuclear reactor whose nuclear-fuel elements are constituted by graphite-encapsulated nuclear fuel particles and have graphite coatings is shut down in accordance with the present invention by introducing into the primary coolant gas circulation, a gadolinium-containing substance which is dispersed in the primary cooling gas before the latter enters the space between the fuel elements within the reactor core so that the gadolinium-containing substance is at least partly deposited on the free graphitic surfaces of the fuel elements.

Abstract: A nuclear power-generating installation comprises three power-generating bines which are operated by three partial gas streams heated in separate passages of a nuclear reactor. After traversing the power-generating turbines the partial gas streams are cooled in respective recuperative heat exchangers to recover residual useful heat therefrom and are combined into a lesser number of gas streams each of which is subjected to at least two compression stages with at least one intervening cooling stage in which all of the gas is combined to flow as a total gas stream through at least one such cooler. Following the last compression stage the gas is again subdivided into three partial streams for preheating in the aforementioned recuperative heat exchangers before traversing the nuclear reactor for the main heating.