Abstract: Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed.

Abstract: A method for assisting the planning of an interventional biventricular pacing procedure includes segmenting an image dataset of a heart of a patient to extract a surface of a left ventricle (LV) and a LV myocardium of the patient's heart, utilizing the segmented image dataset to divide the LV into myocardial segments or into a plurality of short axis slices, and detecting wall motion of each short axis slice of phases of a cardiac cycle of the patient's heart with respect to a reference phase. The method also includes localizing a region most recently attaining maximum displacement and a region most recently attaining maximum velocity, and generating 2D or 3D renderings including renderings indicating at least one of time delays of contraction, a maximum displacement, or a maximum velocity.

Abstract: Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed.

Abstract: The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Abstract: According to an aspect of the present invention, each correlation block in a Global Navigation Satellite System (GNSS) receiver is designed to examine a certain number of consecutive samples of an input signal and a buffer is designed to store more than such number of samples. Due to such storing, each correlator may perform multiple correlations for the same set of received samples. According to another aspect, such searches may be performed without rotating a local code by controlling the specific samples provided as window samples. Thus, while performing Doppler searches, different frequencies can be searched using the same local code without rotation. While performing code phase searches, the window samples may start from different positions with the position determining the specific phase being searched.

Abstract: Provided herein are substituted aromatic compounds, which are tRNA synthetase inhibitors, and hence can be used as antimicrobial agents. Compounds described herein can be used for the treatment or prevention of a condition caused by or contributed to by gram positive, gram negative, anaerobic bacteria or fungal organisms, more particularly against bacterium, for example, Staphylococci, Enterococci, Streptococci, Haemophilus, Moraxalla, Escherichia, Chlamydia, Mycoplasm, Legionella, Mycobacterium, Helicobacter, Clostridium, Bacteroides, Corynebacterium, Bacillus or Enterobactericeae, and fungal organisms, for example, Aspergillus, Blastomyces, Candida, Coccidiodes, Cryptococcus, Epidermophyton, Hendersonula, Histoplasma, Microsporum, Paecilomyces, Paracoccidiodes, Pneumocystis, Trichophyton, or Trichosporium. Processes for the preparation of these compounds, pharmaceutical compositions thereof, and methods of treating microbial infections are also provided.

Abstract: A Global Navigation Satellite System (GNSS) receiver provided according to an aspect of the present invention contains a buffer to store less than a number of samples spanning a code period of a received GNSS signal, with the samples being used by a correlator and a processor to perform various searches in the receiver. Due to the use of such smaller memory space in the buffer, the overall size of receivers may be reduced. According to another aspect of the present invention, the amount of storage provided for storing local code and carrier samples (used during correlation) is also reduced by dynamically generating the local code and carrier sample as required for generating partial correlation results.

Abstract: The present invention involves a process for preparing substituted indoles, such as DTSI involving two sequential cross-coupling reactions.

Abstract: A method for generating a registered image relative to a cardiac cycle and a respiratory cycle of a person is provided. The method includes generating a plurality of 2-D images of an anatomical region of the person. The method further includes generating a 3-D model of the anatomical region of the person. The 3-D model is associated with a predetermined phase of the cardiac cycle and a predetermined phase of the respiratory cycle. The method further includes selecting a first 2-D image from the plurality of 2-D images associated with the predetermined phase of the cardiac cycle and the predetermined phase of the respiratory cycle. The method further includes generating the registered image of the anatomical region utilizing the first 2-D image and the 3-D model. The method further includes storing the registered image in a memory device.

Abstract: The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Abstract: The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Abstract: The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders.

Abstract: The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles.

Abstract: Compounds of the formula: are disclosed. The compounds act as phosphodiesterase-4 modulators, and useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions. Other embodiments are also disclosed.

Abstract: The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles.

Abstract: Aryl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed.

Abstract: 2,4-Diaminoquinazolines of formula (I) are provided herein and are useful for treating spinal muscular atrophy (SMA).

Abstract: The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.

Abstract: Methods for displaying a location of a point of interest on a 3-D model of an anatomical region of a person are provided. In one exemplary embodiment, the method includes generating first and second 2-D images of the anatomical region utilizing an image acquisition system when an X-ray source of the image acquisition system is disposed at first and second positions, respectively, in a 3-D coordinate system of the image acquisition system. The method further includes selecting first and second points in the first and second 2-D images, respectively. The method further includes utilizing a triangulation technique utilizing the first and second points to determine a point of interest in a 3-D coordinate system of the 3-D model of the anatomical region.

Abstract: The present invention is directed to pharmaceutical compositions of 7-(acryloyl)indoles, such as 4,5 -Dichloro-thiophene-2-sulfonic acid [(E)-3-[1-(2,4-dichlorophenylmethyl)-5-fluoro-3-methyl-1H-indol-7-yl]-acryloyl]amide (DTSI), having a structure shown below. The invention is also directed to methods of treatment utilizing formulations of the DTSI and processes of preparation of the formulations.