Abstract: This disclosure provides a patient support for supporting a patient. The patient support comprises a crib assembly comprising a support material with a cover assembly disposed over the crib assembly. The cover assembly defines a recess and comprising a patient support surface having an outer periphery. The patient support further comprises a connector assembly for connecting the patient support to a fluid source with the connector assembly comprising a connector with a plurality of ports. The assembly defines a three dimensional interior corner adjacent the recess in the cover assembly. The connector assembly is disposed in the recess of the cover assembly such that the plurality of ports of the connector are presented for connection to the fluid source at the three dimensional interior corner and inside the outer periphery of the patient support surface.

Abstract: Antibodies are modified by replacing amino acids in the heavy chain CH1, CH2, or CH3 or light chain constant region with selected replacement glutamine-containing sequences to render them amenable to conjugation by the enzyme transglutaminase.

Abstract: Systems and methods related to scheduling of tasks for execution in parallel based on geometric reach are described. An example method includes processing information pertaining to connectivity among superconducting components and nodes included in a shared floor plan to generate a plurality of areas of reach, where each of the plurality of areas of reach corresponds to a portion of the shared floor plan. The method further includes generating a plurality of inflated areas of reach by inflating each of the plurality of areas of reach based on a target inductance of wires for routing signals among the superconducting components and the nodes included in the shared floor plan. The method further includes scheduling parallel execution of tasks for routing wires among a subset of the superconducting components and the nodes within any of the plurality of inflated areas of reach satisfying a geometric constraint.

Abstract: In one embodiment, a method for securely distributing secret keys for hardware devices is disclosed. A distributor server transmits to a provider server an order for hardware devices. Each hardware device has a unique identifier and at least one secret key for authentication. The provider server sends a database associated with the distributor, for each of the hardware devices, the unique identifier and an unencrypted version of the at least one secret key. In response to an order received by the distributor from a customer for a portion of the hardware devices, the distributor server provides the database the unique identifiers and an associated customer order identifier, and the distributor server provides a customer server the unique identifiers. In response to the customer logging into the database and providing the order information, the database provides the customer the unencrypted keys for the hardware devices to allow authentication.

Abstract: Disclosed is a process for preparing (S)-4-(3-(but-2-ynamido)piperidin fluoro-2,3-dimethyl-1H-indole-7-carboxamide, comprising the steps of: preparing a compound of Formula (III); converting the compound of Formula (III) to a compound of Formula (V); and reacting the compound of Formula (V) with a compound of Formula (VI) to provide (S)-4-(3-(but-2-ynamido)piperidin-1-yl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide.

Abstract: In one embodiment, a method for securely distributing secret keys for hardware devices is disclosed. A distributor server transmits to a provider server an order for hardware devices. Each hardware device has a unique identifier and at least one secret key for authentication. The provider server sends a database associated with the distributor, for each of the hardware devices, the unique identifier and an unencrypted version of the at least one secret key. In response to an order received by the distributor from a customer for a portion of the hardware devices, the distributor server provides the database the unique identifiers and an associated customer order identifier, and the distributor server provides a customer server the unique identifiers. In response to the customer logging into the database and providing the order information, the database provides the customer the unencrypted keys for the hardware devices to allow authentication.

Abstract: Aspects of the invention include compositions and methods for treatment of hematological tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-CD20 binding domain or anti-B cell maturation antigen (BCMA) binding domain, a CD8 hinge and transmembrane domain, a costimulatory domain, a CD3 ? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.

Abstract: Aspects of the invention include compositions and methods for treatment of solid tumors with engineered or non-engineered ??-T cells. In some embodiments, the ??-T cells comprise a chimeric antigen receptor (CAR) construct. The CAR construct can contain an anti-TryD binding domain, a CD8? hinge and transmembrane domain, a costimulatory domain, a 003? signalling domain, a combination thereof, or all thereof. The CAR construct can contain an anti-GPC3 binding domain, a CD8? hinge and transmembrane domain, a costimulatmy domain, a CD3? signalling domain, a combination thereof, or all thereof. The CAR construct can contain a domain encoding for a secreted common gamma chain cytokine such as a sIL 15 domain.

Abstract: A head-mounted display comprises a display device and an outward-facing depth camera. A storage machine comprises instructions executable by a logic machine to present one or more virtual objects on the display device, to receive information from the depth camera about an environment, and to determine a position of the head-mounted display within the environment. Based on the position of the head-mounted display, a position of a joint of a user's arm is inferred. Based on the information received from the depth camera, a position of a user's hand is determined. A ray is cast from a portion of the user's hand based on the position of the joint of the user's arm and the position of the user's hand. Responsive to the ray intersecting with one or more control points of a virtual object, the user is provided with an indication that the virtual object is being targeted.

Abstract: The invention features compositions and methods for altering mutations associated with Rett Syndrome (RTT). Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.

Abstract: A system and method are that includes a frame and a weapon mount on the frame that receives a weapon mock-up. The method includes setting up a trainer simulator including opening a transportable shipping container, wherein the transportable shipping container includes a coupled integrated common base frame and a universal mount tower. The method includes assembling a seat and pivoting the universal mount tower from a horizontal position to a vertical position wherein the universal mount tower auto-locks into position. The method includes delivering ground vehicle based weapon system training to a user using a continuum of human interface fidelities that includes a first, second and third fidelity, wherein the user is first delivered training at a first fidelity, and then at a second fidelity and then at a third fidelity. A system for a mission reconfigurable trainer simulation is also presented.

Abstract: A masonry unit including a photovoltaic cell for generation of electricity is described herein. More particularly a photovoltaic-clad concrete block that combines the structural attributes of concrete block (or other masonry unit) and the energy production of solar photovoltaics is described herein. Methods for manufacturing, installing, and electrically connecting such photovoltaic-clad concrete blocks are also described herein.

Abstract: Systems and methods related to scheduling of tasks for execution in parallel based on geometric reach are described. An example method includes processing information pertaining to connectivity among superconducting components and nodes included in a shared floor plan to generate a plurality of areas of reach, where each of the plurality of areas of reach corresponds to a portion of the shared floor plan. The method further includes generating a plurality of inflated areas of reach by inflating each of the plurality of areas of reach based on a target inductance of wires for routing signals among the superconducting components and the nodes included in the shared floor plan. The method further includes scheduling parallel execution of tasks for routing wires among a subset of the superconducting components and the nodes within any of the plurality of inflated areas of reach satisfying a geometric constraint.

Abstract: A method of controlling forward thrust of an aircraft includes receiving a first pitch angle command; generating a second pitch angle command and a forward thrust engine throttle command based on a bounded pitch angle for the aircraft; comparing a determined bounded pitch angle for the aircraft to the pitch angle corresponding to the first pitch angle command; generating a reduced pitch angle command so the resultant aircraft pitch angle does not exceed the bounded pitch angle; and generating the forward thrust engine throttle command based on the reduced pitch angle command.

Abstract: The decorative decal assembly (20) is configured to be secured within a recessed surface (26) of a weight plate (18) and includes an adhesive layer (36), a printable surface (44) of an adjacent ink protective printing layer (42), and one or more print decals (48) secured to the printable surface (44) and between an upper support surface (40) of the adhesive layer (36) and the ink protective layer (42). The recessed surface (26) defines a display area (56) surrounded on all sides by an expansion zone (58) extending between the display area (56) and the shoulders (30, 32) of the weight plate (18) that define the recessed surface (26) to permit limited expansion of perimeter edges (62A, 62B) of the decal assembly (20) into the expansion zone (58) without contacting the shoulders (30, 32) whenever the weight plate (18) experiences a bounce shock.

Abstract: The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Abstract: A wireless communication method to alter RF regulatory channel hopping requirements (regulations) between a pair of transceivers is envisioned wherein an embedded transceiver embedded in an RF attenuating medium transmits signals at a lower hopping requirement than a paired open-air transceiver. The communication method adheres to these regulations, which define a threshold power for transmission above which require a high degree of frequency hopping. Because the attenuating medium attenuates the open-air RF signal from the embedded transceiver, channel hopping in the embedded transceiver is lowered however, the channel hopping in the open-air transceiver is not lowered. The two transceivers are essentially powered equally.

Abstract: A programming session may be initiated to a vehicle ECU by an update device. A software update for the ECU may be authenticated by the update device using an authentication key. When an authentication result indicates successful authentication, the ECU software update is sent by the update device over the in-vehicle network to the ECU. The ECU may then flash a memory with the ECU software update. The authentication key may be obtained from the ECU. The update device may be a vehicle telematics control unit or a service tool coupled to a connector of the vehicle.

Abstract: Disclosed is a method and system method for bulk copying data from a cell grid to a workspace memory, such as a clipboard. According to an exemplary embodiment of this disclosure, the method includes displaying, in a user interface, a plurality of cell rows and a plurality of cell columns arranged in a grid form, a user selecting a plurality of rows of cell entries by selecting a respective selector indicator of all rows to be copied, the selected plurality of rows including a subset of a total number of rows displayed and a noncontinuous group of sequential rows where at least one nonselected row is located and displayed between two selected rows; and displaying, in the user interface, a drop-down menu including a plurality of user selectable options, the user selectable options including a user selectable command to copy the plurality of selected rows and a common predetermined subset of the associated column entries to a workspace memory such as a clipboard.

Abstract: The present invention relates to methods to improve the absolute rate of homology-directed repair (HDR) and/or to improve the relative rate of HDR compared with non-homologous end joining (NHEJ).