Abstract: A method that includes obtaining, for a task, a help file including steps, and generating, from the help file, a knowledge graph for the task, the knowledge graph includes nodes connected by directed edges. Generating the knowledge graph includes, for a step of the set of steps obtaining, from the step, a first step attribute value defining an action type of an action specified by the step, generating a natural language instruction based on the action type and a second step attribute value, in the step, corresponding to a parameter of the action, and storing the natural language instruction in a node. The method further includes storing the knowledge graph.

Abstract: A method includes obtaining a help file including steps for a task and generating a knowledge graph including instructions corresponding to the steps. The method further includes extracting, from a user input of a user, an intent to complete the task. Responsive to extracting the intent to complete the task, obtaining the knowledge graph is obtained. Using the knowledge graph, an instruction of the knowledge graph is presented to perform an action in a workflow to complete the task.

Abstract: The present disclosure relates to cells modified by a Cas12i polypeptide, methods of modifying the cells, processes for characterizing the modified cells, compositions and formulations comprising the modified cells, and uses of the compositions and formulations comprising the modified cells.

Abstract: The present invention concerns pharmaceutical formulations of ARN-509, which can be administered to a mammal, in particular a human, suffering from an androgen receptor (AR)-related disease or condition, in particular cancer, more in particular prostate cancer, including but not limited to castration-resistant prostate cancer, metastatic castration resistant prostate cancer, chemotherapy-naïve metastatic castration resistant prostate cancer, biochemically relapsed hormone sensitive prostate cancer, or high-risk, non-metastatic castration-resistant prostate cancer. In one aspect, these formulations comprise a solid dispersion of ARN-509 and HPMCAS. In one aspect, the solid dispersion of ARN-509 and HPMCAS is obtainable, in particular is obtained, by melt-extruding a mixture comprising ARN-509 and HPMCAS and optionally subsequently milling said melt-extruded mixture.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Abstract: Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

Abstract: Systems and methods for generating a data aggregator interactive graphical user interface. An interactive graphical user interface (GUI) includes a selectable symbol region, a query region and a data results region. The selectable symbol region displays predefined symbols. The query region displays user input fields for generating queries. The system receives user input associated with the user input fields of the query region to form a filter set. The data results region is automatically updated responsive to the user input, to display one or more data values from among one or more databases associated with the filter set. The system receives a subscription request to save the filter set as a user-customized query. A custom symbol is created responsive to the subscription request that is associated with the filter set. The the selectable symbol region is updated to display the custom symbol together with the predefined symbols.

Abstract: A task managing system for testing and configuring one or more vehicles includes a plurality of task execution controllers. Each of the plurality of the task execution controllers defines a set of communication nodes configured to wirelessly communicate with a set of vehicles of a plurality of vehicles. The task execution controller includes a processor configured to execute instructions stored in a nontransitory computer-readable medium to operate as a task application module configured to execute a task order on a selected vehicle from the set of vehicles by way of a selected communication node from the set of communication nodes.

Abstract: A system includes a memory storing computer-readable instructions and at least one processor to execute the instructions to receive a shot sheet comprising data and metadata associated with an animation project, parse the shot sheet to generate instructions associated with at least one shot in the animation project, send the instructions to an animation program using an application programming interface (API), generate the animation project based on the instructions using the animation program, render the animation project into a video, and store the video in a database and generate a uniform resource locator (URL) for the video.

Abstract: A system includes a vehicle managing system (VMS) and a task managing system (TMS). The VMS is configured to communicate to a selected vehicle and is configured to include a vehicle connection module (VCM) and a task allocation module (TAM). The VCM is configured to identify the selected vehicle based on a vehicle identifier of the selected vehicle. The TAM is configured to obtain a task order associated with the selected vehicle, where the task order defines one or more tasks to be performed on the selected vehicle. The TMS includes multiple task execution controllers (TECs) and a task scheduling controller (TSC). The TAM of the VMS is configured to provide the task order for the selected vehicle to the TSC, and the TSC is configured to assign the task order to a selected TEC, which executes the task order for the selected vehicle.

Abstract: Systems and methods for aggregating data. The system is configured to receive metadata from an interactive graphical user interface (GUI) of a user device, aggregate field values from the data stored on one or more databases based on the received metadata and generate filter instructions based on the received metadata. The system is further configured to transmit the aggregated field values and the filter instructions to the user device, receive a user-customized filter set and subscription request for a synthetic symbol associated with the user-customized filter set from the user device, and create the synthetic symbol responsive to the subscription request. Moreover, the system aggregates one or more data values from the data stored on the databases associated with the created synthetic symbol and generates instructions to display the data values on the interactive GUI in accordance with the user-customized filter set associated with the created synthetic symbol.

Abstract: In one embodiment, an optical module includes an electronic integrated circuit, a photonic integrated circuit, and a pluggable optical coupling connector. The photonic integrated circuit sends or receives optical signals. The pluggable optical coupling connector is adjacent to the photonic integrated circuit and includes a pluggable interface to optically couple a fiber array to the photonic integrated circuit. Further, the electronic integrated circuit, the photonic integrated circuit, and the pluggable optical coupling connector are all embedded in a mold.

Abstract: The disclosure provides compositions, kits, and methods for detecting/identifying amino acids and sequencing polypeptide molecules.

Abstract: The disclosure relates to stable topical pharmaceutical compositions of SHR0302 (also known as ARQ-250). In certain embodiments, pharmaceutical compositions of SHR0302 having a pH of less than about 4.6 have improved stability and do not exhibit crystal formation of the API. In certain embodiments, pharmaceutical compositions of SHR0302 comprising about 20% to about 30% dimethyl sulfoxide (DMSO) have improved stability and do not exhibit crystal formation of the API. The improved formulations of SHR0302 can exhibit acceptable commercial product shelf life and do not exhibit loss of potency of the API after prolonged storage.

Abstract: A liquid dispersion device comprising an elongated dispersion body comprising a first end extending in a first direction and forming an elongated dispersion body comprising a first end positioned at an acute angle relative to a longitudinal axis of the elongated dispersion body, a second end positioned at an obtuse angle relative to the longitudinal axis of the elongated dispersion body, a plurality of nozzles extending outwardly from a forward surface of the dispersion body and a source connector on a rear surface of the dispersion body, the source connector in fluid communication with the plurality of nozzles. A first nozzle among the plurality of nozzles is positioned on the forward surface of the dispersion body at the first end of the dispersion body and a second nozzle is positioned on the forward surface of the dispersion body at the second end of the dispersion body.

Abstract: Systems and methods related to scheduling of tasks for execution in parallel based on geometric reach are described. An example method includes using a processor, processing information pertaining to a type of task to generate a plurality of areas of reach, where each of the plurality of areas of reach corresponds to a portion of a shared space. The method further includes using the processor, generating a plurality of inflated areas of reach by inflating each of the plurality of areas of reach based on a task-specific factor pertinent to the type of task. The method further includes automatically scheduling parallel execution of tasks associated with any of the plurality of inflated areas of reach satisfying a spatial constraint.

Abstract: A novel maize variety designated X18P228 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X18P228 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X18P228 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X18P228, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X18P228 are provided. Methods for producing maize varieties derived from maize variety X18P228 and methods of using maize variety X18P228 are disclosed.

Abstract: Apparatuses and methods for data traffic management in multi-source content delivery are described. The apparatus includes a downloader and a controller. The downloader is coupled to servers via communication links. The controller is configured to determine initial download requests for the servers based on predetermined information about a quality of the links. The controller is also configured to send the initial download requests to the servers with the downloader. The controller is further configured to update the information about the quality of the communication links after the downloader receives data associated with a data file from the servers via the communication links. The controller is also configured to determine subsequent download requests for the servers based on the updated information about the quality of the communication links. The controller of further configured to send the subsequent download requests to the servers via the downloader.

Abstract: A modular electro-mechanical agent having a plurality of modules including mechanical and electrical components, that can be constructed to complete at least one pre-determined task and/or contribute in performing the at least one pre-determined task. The electro-mechanical agent can include extension modules and can be altered as per user preference to add, eliminate or modify any features of the agent for completing and/or participating in a plurality of pre-determined tasks.

Abstract: Provided herein are compositions and methods of using base editors comprising a polynucleotide programmable nucleotide binding domain and a nucleobase editing domain in conjunction with a guide polynucleotide. Also provided herein are base editor systems for editing nucleobases of target nucleotide sequences.