Abstract: The present invention features compositions and methods for editing a gene associated with Shwachman Diamond Syndrome (SDS) using a programmable nucleobase editor, such that the gene is permissive for transcription and generates a functional gene product (e.g., providing a splice site and/or altering a nonsense mutation).

Abstract: A head-mounted display comprises a display device and an outward-facing depth camera. A storage machine comprises instructions executable by a logic machine to present one or more virtual objects on the display device, to receive information from the depth camera about an environment, and to determine a position of the head-mounted display within the environment. Based on the position of the head-mounted display, a position of a joint of a user's arm is inferred. Based on the information received from the depth camera, a position of a user's hand is determined. A ray is cast from a portion of the user's hand based on the position of the joint of the user's arm and the position of the user's hand. Responsive to the ray intersecting with one or more control points of a virtual object, the user is provided with an indication that the virtual object is being targeted.

Abstract: The present disclosure relates to managing services by a managed service provider (MSP) in a cloud based infrastructure. A control plane of the MSP is established in a first tenancy, and a first access plane of the MSP is established in a second tenancy of a cloud environment. The control plane is configured to manage a plurality of services offered by the MSP to a first host machine included in the second tenancy. A first request is transmitted from the control plane to the first access plane, where the first request is forwarded by the first access plane to the first host machine, and corresponds to a service utilized by the first host machine and managed by the control plane of the MSP. In response to the first request being validated, a first state of the first host machine is modified in the second tenancy based on the first request.

Abstract: Markers may be presented on different objects in a facility, such as shelves or totes. A marker can use color, placement of elements, blending effects, or infrared light layers to encode data about the object. During operation, a camera within the facility may acquire an image, which includes an image of the marker as presented on the object. The marker can be analyzed to detect marker data encoded therein. By decoding the marker data, details about the marker can be extracted, such as an identification of the object. In addition, using details about the marker location within the image and location data associated with the camera, a location of the object relative to the camera can be determined, as well as an orientation of the object relative to the camera. As the object moves within the facility, the object can be tracked based on this location and orientation data.

Abstract: Methods and compositions for improving the genome-wide specificities of targeted base editing technologies.

Abstract: This invention relates to a parachute sea anchor system deployable from a payload tube. There is provided a parachute sea anchor system suitable for launch from a vessel comprising at least one payload tube, said payload tube, comprising a payload canister, which comprises a parachute sea anchor, wherein said parachute sea anchor comprises a buoy tethered thereto, wherein said payload canister is attached to said vessel.

Abstract: A polymer suitable for use in a thin film hinge (living hinge) comprising from about 0.1 to about 5 weight % of a C4-8 comonomer and the balance ethylene, said composition having a density as determined according to ASTM D 792 from about 0.945 to about 0.965 g/cm3; a melt index as determined according to ASTM D1238 (2.16 kg/190° C.) from about 10 to about 20 g/10 min; a weight average molecular weight (Mw) from about 45,000 to about 55,000 g/mol; a polydispersity from about 2.5 to about 3.1 and when molded into a strip having a length of about 13 cm and gross thickness from about 50 to about 70 mil (about 1 to about 2 mm) and completely bent over end to end four times to create a thinned region or crease having a thickness from about 15 to about 30 mil (about 0.3 to about 0.7 mm) tested by bending and releasing the deformed thinned region of the strip through a radius of curvature from about 180 to about 190° about a rounded plate goes through not less than 500 cycles without breaking.

Abstract: A computer-implemented method for determining focus of a user is provided. User input is received. An intention image of a scene including a plurality of interactive objects is generated. The intention image includes pixels encoded with intention values determined based on the user input. An intention value indicates a likelihood that the user intends to focus on the pixel. An intention score is determined for each interactive object based on the intention values of pixels that correspond to the interactive object. An interactive object of the plurality of interactive objects is determined to be a focused object that has the user's focus based on the intention scores of the plurality of interactive objects.

Abstract: A device for compressing subject data. the device comprises a communication link, the communication link capable of receiving a set of subject data; a compression module, the compression module configured to apply a compression algorithm to the set of subject data, the compression algorithm compressing the set of subject data using a reference string of subject data; and a transmission module, the transmission module configured to transmit the compressed subject data. The device further comprising an encryption module for encrypting the subject data.

Abstract: An adjustable mounting apparatus for mounting electronic devices and objects of various sizes on a flat surface comprises a first bracket and a second bracket. Each of the first and second brackets comprise a substantially horizontal plate, a substantially vertical plate, a back plate extending substantially vertically from a second transverse edge of the substantially horizontal plate, and a reusable adhesive layer disposed at a rear portion of the back plate. The substantially horizontal plate of each of the first and second brackets comprise a first retaining abutment extending substantially vertically from a first transverse edge of the substantially horizontal plate. The substantially vertical plate of each of the first and second brackets comprise a second retaining abutment extending substantially laterally from a first transverse edge of the substantially vertical plate.

Abstract: Methods and systems for an electric motor-generator in a vehicle are provided. In one example, an electric motor-generator is provided that includes an engine interface configured to rotationally couple to a first engine, a transmission interface configured to rotationally couple to a first transmission of the first engine, and a rotor with a plurality of magnets at least partially surrounding a stator including a plurality of coils. The rotor is rotationally coupled to the engine interface and the transmission interface.

Abstract: A method for processing requests to consolidate loans includes receiving, from one or more third party electronic computing devices, information regarding outstanding loans for a user that are issued by one or more third party lenders. The information is sent to a user electronic computing device. A selection is received of loans the user wishes to refinance or consolidate. A benefits analysis is performed for the loans. Based on the benefits analysis, a determination is made of whether any of the outstanding loans can be consolidated, and whether any of the loans are excluded from being consolidated. Consolidated loan information is sent to the user electronic computing device regarding a consolidated loan for any of the loans that can be consolidated. Exclusion information is sent to the user electronic computing device regarding any of the loans that are excluded from being consolidated.

Abstract: Display assemblies as disclosed herein are configured for attachment with a vulcanized rubber article and are provided in the form of different material layers. Display assemblies generally comprise one or more display layers of elastomeric material configured to provide a desired display indicia, an intermediate layer formed from an elastomeric material different from that of the one or more display layers, and an adhesive layer wherein the intermediate layer is interposed between the adhesive layer and the one or more display layers. The one more display layers may be configured to act together or separately to provide a desired display indicia to provide a desired visual display or feature on the surface of the vulcanized rubber article, which may be a sidewall surface of a tire.

Abstract: Apparatuses and methods for data traffic management in multi-source content delivery are described. The apparatus includes a downloader and a controller. The downloader is coupled to servers via communication links. The controller is configured to determine initial download requests for the servers based on predetermined information about a quality of the links. The controller is also configured to send the initial download requests to the servers with the downloader. The controller is further configured to update the information about the quality of the communication links after the downloader receives data associated with a data file from the servers via the communication links. The controller is also configured to determine subsequent download requests for the servers based on the updated information about the quality of the communication links. The controller of further configured to send the subsequent download requests to the servers via the downloader.

Abstract: Some embodiments relate to a method for performing a battery power-based control of an in-call experience based on shared battery power information. Some embodiments relate to a coating of a headset that has a first emissivity over an ultraviolet band and a near-infrared band, a second emissivity over a visible band, and a third emissivity over a mid-to-far infrared band. Some embodiments relate to an aggregate coating of a headset. A thin films is applied to a surface of the headset, and a paint coating is applied to a surface of the thin film to form the aggregate coating. Some embodiments relate to a method for a high-definition multimedia interface derived network timing for distributed audio-video synchronization. Some embodiments relate to a battery containment structure with a metal chassis having surfaces coated with electrical insulators configured to receive a battery, and a lid coupled to the metal chassis.

Abstract: Described are systems and methods to provide agnostic sensor data obtained from a sensor and transmitted to a central database by a transmitter device. In one aspect, a value sensed by a sensor component is converted at the transmitter device to an agnostic value defined by a dimensionless universal scale and offset. The agnostic value is then sent to a data acquisition database where it is converted back to the original value. This is accomplished by first providing the data acquisition database with a sensor definition of a scale and offset used to convert the sensor values in addition to any sensor indicia and other parameters to display the data acquired at the data acquisition database. The wireless sensors database and user interface are also automatically updated when a new sensor type is attached to the network utilizing configuration data that resides in the new sensor that is sent to the database on its first connection.

Abstract: An automatic parts delivery system includes a controller, fleets of robots, an autonomous storage-retrieval system and workstations. The controller monitors inventory state of automotive parts during a selected block of time and identifies unavailability of parts for manufacturing a selected vehicle model. The controller determines whether remaining parts can be used to manufacture another vehicle model. The fleets of robots scan, deliver and sort parts and prepare a custom kit including at least the remaining parts. The custom kit is delivered to produce another vehicle model at the workstations for producing the selected vehicle model or another vehicle model.

Abstract: The disclosure provides compositions comprising novel adenosine base editors (e.g., ABE8) that have increased efficiency and methods of using these adenosine deaminase variants for editing a target sequence.

Abstract: A coated glass article includes a glass substrate and an anti-reflective coating formed over a first major surface of the glass substrate. The anti-reflective coating includes a color suppression interlayer and a first coating layer deposited over the color suppression interlayer. The first coating layer includes tin oxide and a dopant. The dopant includes antimony, molybdenum, or iron. A second coating layer is deposited over the first coating layer. The second coating layer includes an oxide of silicon. The coated glass article exhibits a total visible light transmittance of 70% or more and a film side visible light reflectance of less than 6.0%.