Abstract: Various embodiments of the present disclosure relate to a cache stickiness index for providing measurable metrics associated with caches of a content delivery networking system. In one embodiment, a method for generating a cache stickiness index, including a cluster stickiness index and a region stickiness index, is disclosed. In embodiments, the cluster stickiness index is generated by comparing cache keys shared among a plurality of front-end clusters. In embodiments, the region stickiness index is generated by comparing cache keys shared among a plurality of data centers. In one embodiment, a system comprising means for generating a stickiness index is disclosed.

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.

Abstract: Storing data in a cache is disclosed. It is determined that a data record is not stored in a cache. A random value is generated using a threshold value. It is determined whether to store the data record in the cache based at least in part on the generated random value.

Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active to components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.

Abstract: A storage area network (SAN), which includes one or more remote systems, a plurality of storage devices, a SAN fabric comprising a plurality of fabric components for coupling the remote systems to the storage devices, and a central system having a SAN management server configured to monitor an amount of available storage in a file system used in the remote systems, and automatically provision additional storage to the file system in the event the amount of available storage in the file system decreases below a predetermined amount.

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract: Light emitting devices include a first string of LEDs that emit light having a color point that is within at least eight MacAdam ellipses of a first blue-shifted-yellow region on the 1931 CIE Chromaticity Diagram, a second string of LEDs that emit light having color point that is within at least eight MacAdam ellipses of a second blue-shifted-green region on the 1931 CIE Chromaticity Diagram, and a third light source that emits radiation having a dominant wavelength between 600 and 720 nm. A drive circuit supplies respective drive currents to the first string of LEDs, the second string of LEDs and the third light source, at least two of which are independently controllable.

Abstract: According to one aspect, the subject matter described herein comprises methods, systems, and computer program products for automatically adjusting a replication rate based on a specified quality of service (QoS) level. The method includes providing for the specification of a QoS level associated with the performance of at least one application operating on a data storage system and determining a performance measure of the at least one application. A data replication rate of the data storage system is also determined and, based on the QoS level and the performance measure of the at least one application, the data replication rate is automatically adjusted.

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.

Abstract: The present disclosure relates to a lighting apparatus that includes a light engine that is coupled to a heat sink. The light engine provides a light source that generates light, and heat that is generated by the light source is dissipated, at least in part, via the heat sink.

Abstract: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included to control loading of process materials, facilitate mixing and reconstitution of dried reagents, limit evaporation, control heating of reaction materials, concentrate solid support materials to prevent clogging of fluid connections, provide minimum volumes for fluid transfers, and to prevent process materials from sticking to chamber surfaces. The receptacles can be adapted for use in systems having a processing instrument that includes an actuator system for selectively moving fluid substances between chambers and a detector. The actuator system can be arranged to concentrate an analyte present in a sample.

Abstract: A method is used in managing cache pages. A location pointer is maintained in a dynamic list of entries for cache page cleaning. The dynamic list includes a list of cache pages ordered from most recently used to least recently used. Based on flags associated with the cache pages, a count of the number of cache pages processed for cache page cleaning is maintained. In response to a change in the dynamic list, the location pointer and count are updated based on the processing status of an entry to which the change pertains.

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

Abstract: The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.

Abstract: A lighting device comprising first and second groups of solid state light emitters, that emit light having approximate dominant wavelength (in nm) of 441-448 (or 442-450, 444-455, 444-446, 442-445 or 444-452) and 555 nm to 585 nm, respectively. If the first and second groups are illuminated, a mixture of light would, in the absence of any additional light, have a color point within one or more of first, second, third, fourth and fifth areas on the 1931 CIE Chromaticity Diagram. In some embodiment, the lighting device further comprises a third group that emits light having approximate dominant wavelength (in nm) of 600-640 (or 605-610, 605-607, 600-606, 602-606 or 615-620). Also, methods of lighting.

Abstract: Storing data in a cache is disclosed. It is determined that a data record is not stored in a cache. A random value is generated using a threshold value. It is determined whether to store the data record in the cache based at least in part on the generated random value.