Abstract: The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

Abstract: Techniques for estimating the impact of new operational conditions in a baseline air traffic scenario are described. For at least one flight, embodiments infer an aircraft intent that fits corresponding flight track data. A reconstructed trajectory is computed using the inferred aircraft intent. For at least one flight in an alternative air traffic scenario, an aircraft intent that fits new operational conditions is generated. The new operational conditions include a new air traffic management operation and a new air traffic procedure, and the generated aircraft intent conforms to the new air traffic management operation and the new air traffic procedure. Embodiments compute a generated trajectory of the at least one flight in the alternative air traffic scenario using the generated aircraft intent and compute trajectory-based analytics on each computed trajectory of the baseline and alternative air traffic scenarios using a set of metrics.

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.

Abstract: A computer-implemented method, system and computer program product for estimating the impact of new operational conditions in a baseline air traffic scenario. The system comprises: an intent inference module for retrieving flight track data and associated aircraft type information of a flight in a baseline air traffic scenario, and inferring an aircraft intent that fits the flight track data; an intent generation module for, using an alternative air traffic scenario based on the baseline air traffic scenario with new operational conditions, generating an aircraft intent for each flight in the alternative air traffic scenario that fits the new operational conditions; a trajectory computation module for computing the trajectory of each flight in the baseline and alternative air traffic scenario using their aircraft intent; an evaluation module for computing a trajectory-based analytics on each computed trajectory of the baseline and alternative air traffic scenario using a set of metrics.

Abstract: Treatment of cancer is disclosed through administration of proteins or specific peptides that are uptaken by dendritic cells, wherein said dendritic cells as subsequently activated and administered, in vivo, in a matter eliciting monocyte or dendritic cell migration in order to allow uptake of said administrated proteins or peptides, followed by administration of a maturation signal in vivo. Alternatively said immature dendritic cells are grown ex vivo in an autologous or semiallogenenic manner derived utilizing conventional means and pulsed with tumor peptides disclosed herein and subsequently administered. In some embodiments of the invention said dendritic cells are treated with epigenetic modifiers to enhance antigen presentation. The invention provides for treatment of cancer through induction of anticancer immunity and/or immunity towards tumor associated blood vessels.

Abstract: This disclosure provides a joint assembly that thermally isolates a warm structure, such as a payload, from a cold structure, such as a cryogenic fuel tank, in a space vehicle while maintaining structural interconnection within the joint assembly. The joint assembly includes a primary joint that is capable of separating, and a secondary joint connected to and adjacent to the primary joint. The secondary joint includes an inflatable annulus structure and one or more restraining members, where separation of the primary joint causes the inflatable annulus structure to be in compression and the one or more restraining members to be in tension.

Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.

Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.

Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.

Abstract: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.

Abstract: Reagents and methods are provided that allow for an improved expression of a recombinant protein. More specifically, the introduction of recombinant DNA elements into a host cell allows for the increased expression of a recombinant protein, an improvement of the correct folding of said protein and an increase in cell viability and proliferation of the host cell, These recombinant DNA elements can be introduced into host cells, for example, via a recombinant baculovirus, which has incorporated said elements. The recombinant DNA elements include nucleic acids encoding transcriptional regulators, such as IE-0 and IE-1, transcriptional enhancer elements, such as the homologous region (hr) and promoters.

Abstract: A header of an agricultural harvester or plant cutting machine is provided that includes a shaft sealing assembly for a center knife drive assembly having an output shaft, a cover, and a pressurized air source. The shaft sealing assembly is fastened to the cover, circumscribes the output shaft and conveys pressurized air for cleaning.

Abstract: A header of an agricultural harvester or plant cutting machine is provided that includes a shaft sealing assembly for a center knife drive assembly having an output shaft, a cover, and a pressurized air source. The shaft sealing assembly is fastened to the cover, circumscribes the output shaft and conveys pressurized air for cleaning.

Abstract: Pyrazole carboxamide compounds of Formula I are provided, with various substituents, and including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk, and for treating cancer and immune disorders such as inflammation mediated by Btk. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract: A method for detecting presence of a macromolecule of interest in a test droplet. A set of detection electrodes are provided in contact with a fluidic channel. The test droplet is provided in vicinity of the detection electrodes through the fluidic channel. An alternate current (AC) power at a first frequency is applied across the set of detection electrodes. A first measurement value that reflects electrical characteristics (e.g., impedance) of the test droplet at the first frequency is obtained. This value is compared with a corresponding reference value, wherein the corresponding reference value is obtained by measuring a reference droplet containing the macromolecule of interest or free of the macromolecule at the first frequency. The presence of the macromolecule in the test droplet is thus determined based on the comparison.

Abstract: An exemplary single bed reversing blower adsorption based air separation unit is configured to follow the O2 load placed thereon by adjusting flow rates therethrough and power consumption. At least one and preferably multiple pressure sensors sense O2 pressure within an O2 storage region downstream of an adsorber vessel. These sensed pressures are utilized to generate control signals controlling flow rates at locations upstream of the compressor, such as at a reversible blower and an output compressor. Control loops for the blower and the compressor are independent of each other and have different time constants. Effective following of the O2 load is thus achieved without driving the air separation unit into operational conditions outside of design and also maintaining optimal power consumption for the O2 produced, such that efficiency is maintained over a large turndown ratio.

Abstract: The present invention may be included in the field of biotechnology and it covers the improved production of recombinant proteins in insect cells or insect larvae as biofactories by a novel expression cassette. This expression cassette comprises nucleic acid sequences such as promoters, homologous regions (hr) as enhancers, and sequences encoding transcriptional regulators, for example, the baculovirus Ac-ie-01 cDNA, or any combination thereof, which are able to increase the quality and production efficiency of the recombinant proteins. Moreover, the present invention is also directed to the vectors themselves comprising the above mentioned nucleic acid sequences of the invention, cells or insects infected, transformed or transfected with those sequences or vectors, and methods for producing the recombinant proteins by using the aforesaid sequences, vectors, cells or insects.

Abstract: The present invention relates to a process for the preparation of diosmin from hesperidin. The process involves the oxidation of acylated hesperidin with iodine or bromine in a C2-C4 carboxylic acid medium and subsequent treatment with an inorganic base to partially neutralize the acidic media. The process allows obtaining diosmin with low iodine or bromine content, avoiding the use of organic solvents.

Abstract: A method includes generating an initial flight context that includes a set of unresolved flight constraints. The method further includes generating a decision tree based on the initial flight context. The decision tree includes a plurality of flight contexts corresponding to leaves of the decision tree. The method also includes expanding the decision tree according to a greedy best-first strategy that selects a flight context of the decision tree for expansion based on a fitness value assigned to the flight context. The method includes selecting, as a piloting strategy, a flight context of the decision tree that includes a sequence of actions to resolve each of the unresolved flight constraints. The method further includes flying an aircraft according to the piloting strategy.

Abstract: The invention relates to a process for producing polymer composites suitable for absorbing and storing aqueous liquids, to the polymer composites obtainable by this process, and to the use of the polymer composites. The process comprises free-radical polymerization of a monomer composition M comprising 50 to 100% by weight, based on the total amount of monomers A and B, of at least one monomer A having one ethylenic double bond and at least one neutralizable acid group, 0 to 50% by weight of optionally one or more comonomers B which are different than the monomers A and have one ethylenic double bond, and 1 to 10% by weight, based on the total amount of monomers A and B, of at least one crosslinker C.