Abstract: An exemplary single bed reversing blower adsorption based air separation unit is configured to follow the O2 load placed thereon by adjusting flow rates therethrough and power consumption. At least one and preferably multiple pressure sensors sense O2 pressure within an O2 storage region downstream of an adsorber vessel. These sensed pressures are utilized to generate control signals controlling flow rates at locations upstream of the compressor, such as at a reversible blower and an output compressor. Control loops for the blower and the compressor are independent of each other and have different time constants. Effective following of the O2 load is thus achieved without driving the air separation unit into operational conditions outside of design and also maintaining optimal power consumption for the O2 produced, such that efficiency is maintained over a large turndown ratio.

Abstract: The invention relates to the field of watermelon grafting. In particular, double grafted watermelon seedlings and plants are provided and methods for producing such double grafted seedlings and plants.

Abstract: A method and system for dynamically establishing content advertisements where the method comprises the steps of (a) receiving a content request from a user device where said request includes information for identifying said user, (b) obtaining the profile of the user from said identification information of the user, (c) obtaining an advertising plan for said content requested for said user based on the profile of said user and the advertising spaces available in said content where said obtainment of the plan comprises the steps of (i) selecting a first set of advertisements, the target audience of which has the same characteristics as those of the profile of said user, (ii) selecting a subset of said first set of advertisements which fulfill the following: they have not fulfilled the coverage objective or is not within the coverage range which they had fixed and they have not fulfilled the objective number of impacts or is not within the range of advertising impacts for said user, or they have fulfilled the c

Abstract: The invention relates to a formable composition for the preparation of engineered stone comprising a cobalt free prepromoted unsaturated polyester resin system, an inorganic particulate material and a peroxide component. The invention also relates to a method for the preparation of engineered stone as well as to the use of the cobalt free prepromoted unsaturated polyester resin system for the preparation of engineered stone.

Abstract: Reagents and methods are provided that allow for an improved expression of a recombinant protein in an insect, More specifically, the introduction of recombinant DNA elements into an insect larva allows for the increased expression of a recombinant protein, an improvement of the correct folding of said protein and an increase in the survival rate after infection of the insect These recombinant DNA elements can be introduced, for example, into insect larvae via a recombinant baculovirus, which has incorporated said elements. The recombinant DNA elements include nucleic acids encoding transcriptional regulators, such as IE-0 and IE-1, transcriptional, enhancer elements, such as the homologous region (hr) and promoters.

Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.

Abstract: The invention disclosed provides populations and compositions of mesenchymal stem and progenitor cells derived from adult tissues that are subjected to a process or processes designed to enhance a biological mechanism prior to implantation of the cells for therapeutic use. The processes involve preconditioning of said mesenchymal stem cells with a physiological stressor in vitro, so as to enhance therapeutically significant biological properties. Specific embodiments of the invention include stimulation of angiogenic and immune modulatory properties by preconditioning with interferon-gamma, as well as other physiologically-relevant stressors such as activation of toll like receptors. Immunologically-relevant properties of preconditioned cells including the treatment of cytokine storm associated with sepsis, or viral infection. In the angiogenic embodiment of the invention, cells are used for the treatment of peripheral artery disease, its advanced form, critical limb ischemia, or ischemic heart failure.

Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

Abstract: A computer-implemented method and a system for setting up an air traffic management (ATM) simulator in an airport are described herein. The method performs the steps of receiving a set of undetermined parameters and rules (112) for configuring an ATM simulator (114) in an airport; retrieving a historical data set of variables associated with trajectory and aircraft states in an airspace region during a time interval; statistically analyzing the historical data set for modelling the airspace region and the airport, and identifying relationships between variables of the historical data set during the time interval relating to at least one undetermined parameter or rule (112); determining a parameter value (160) or rule (140,170) for configuring the ATM simulator corresponding with the at least one identified relationship.

Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.

Abstract: A process for preparing water-absorbing polymer particles, comprising polymerization of a foamed monomer solution or suspension, drying, grinding and classification.

Abstract: This application discloses compounds according to generic Formula (I) wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.

Abstract: This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

Abstract: A computer-implemented method, system and computer program product for estimating the impact of new operational conditions in a baseline air traffic scenario. The system comprises: an intent inference module for retrieving flight track data and associated aircraft type information of a flight in a baseline air traffic scenario, and inferring an aircraft intent that fits the flight track data; an intent generation module for, using an alternative air traffic scenario based on the baseline air traffic scenario with new operational conditions, generating an aircraft intent for each flight in the alternative air traffic scenario that fits the new operational conditions; a trajectory computation module for computing the trajectory of each flight in the baseline and alternative air traffic scenario using their aircraft intent; an evaluation module for computing a trajectory-based analytics on each computed trajectory of the baseline and alternative air traffic scenario using a set of metrics.

Abstract: A valve (30) for controlling a flow of fluid, the valve having a conduit, first valve portion having an inlet, a first humidifier interface, and a first conduit opening to the conduit. The first valve portion defines a switchable flow path between the inlet and either the first humidifier interface or the first conduit opening. A second valve portion has an outlet, a second humidifier interface, and a second conduit opening to the conduit. The second valve portion defines a switchable flow path between the outlet and either the second humidifier interface or the second conduit opening. Responsive to the first and/or second humidifier interfaces being connected to a humidifier chamber, the fluid flows from the inlet to the outlet through the humidifier chamber, and responsive to the first and second humidifier interfaces being disconnected from the humidifier chamber, the fluid flows from the inlet to the outlet through the conduit.

Abstract: The present disclosure provides a feedback control system and method for a bidirectional VCM. The system employs an analog core that is common to both the PWM and linear modes of operation. The analog core includes a feedback mechanism that determines the error in the current flowing through the motor. The feedback mechanism produces an error voltage that corresponds to the current error, and applies the voltage to a control driver. The control driver then controls the motor, based on the error voltage, in either a PWM or linear mode. By sharing a common core, the switching time between modes is improved. Furthermore, the output current error between modes is reduced.

Abstract: This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

Abstract: A system includes a microfluidic device configured to isolate one or more particles from a mixture, a flow rate matching device configured to match flow rate of the microfluidic device with flow rate of an electrical measurement device configured to measure an electrical property of the isolated particles, and an electrical measurement device configured to measure an electrical property of the isolated particles.

Abstract: A transmission system and method for use in a mobile communication network comprising an active antenna arrangement of multiple antennas. The active antenna arrangement comprising several pairs of radiofrequency sub-modules each radiofrequency sub-module including a first phase shifter module, a TRX module and a radiating antenna element and where an dynamic phase offset is applied to one of the sub-modules of each pair, and where the phase offset vector is selected according to the signal quality received by users of the mobile communication network using an algorithm which minimizes the duration of the selection process.

Abstract: Compositions, methods of use, and pharmaceutical preparations useful for modulation of immune responses are disclosed herein. In one embodiment a composition is extracted from immune organs or leukocytes derived from members of the chondrichthyes family through dialysis. Said immune modulator is useful for treatment of conditions requiring stimulations or regulation of immunity. In one embodiment, said immunomodulator controls T cell activation by modulation of cytokine production.