Patents by Inventor Jay D. Keasling

Jay D. Keasling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10876139
    Abstract: The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ?,?-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: December 29, 2020
    Assignee: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • Publication number: 20200385766
    Abstract: This present invention provides for a genetically modified host cell, or a cell-free reaction system, and related methods and materials for the biocatalytic production of an alkyl lactones from a hydroxy fatty acid, or natural alkyl lactones and esters from sugars using non-natural combinations of enzymes.
    Type: Application
    Filed: March 5, 2020
    Publication date: December 10, 2020
    Applicant: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • Patent number: 10844406
    Abstract: Compositions and methods for production of fatty alcohols using recombinant microorganisms are provided as well as fatty alcohol compositions produced by such methods.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: November 24, 2020
    Assignee: Genomatica, Inc.
    Inventors: Jay D. Keasling, Zhihao Hu, Chris Somerville, George Church, David Berry, Lisa C. Friedman, Andreas Schirmer, Shane Brubaker, Stephen B. Del Cardayre
  • Patent number: 10760069
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • Publication number: 20200270597
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Application
    Filed: December 2, 2019
    Publication date: August 27, 2020
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20200231990
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Application
    Filed: February 10, 2020
    Publication date: July 23, 2020
    Applicant: The Regents of the University of California
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Patent number: 10717972
    Abstract: The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: July 21, 2020
    Assignee: The Regents of the University of California
    Inventors: Charles M. Denby, Jay D. Keasling, James Kirby, Rachel Alexandra Li
  • Publication number: 20200172917
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 4, 2020
    Applicant: The Regents of the University of California
    Inventors: Jay D. KEASLING, Leo D'ESPAUX, Jeff WONG, Xiaozhou LUO, Michael REITER, Charles DENBY, Anna LECHNER
  • Patent number: 10597685
    Abstract: The present invention provides for a method of producing an oxidation product of an aromatic amino acid in a genetically modified host cell. The method comprises culturing the genetically modified host cell under a suitable condition such that the culturing results in the genetically modified host cell producing oxidation product of an aromatic amino acid. The host cell comprises an enzyme capable of catalyzing the oxidation of aromatic amino acid. In some embodiments, the host cell is capable of biosynthesizing BH4 or MH4 from GTP.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Taek Soon Lee, Yasuharu Satoh, Jay D. Keasling
  • Patent number: 10563211
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: February 18, 2020
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
  • Patent number: 10557152
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: February 11, 2020
    Assignee: The Regents of the University of California
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Publication number: 20200017865
    Abstract: The present invention provides for a method for editing a genome of a mitochondria or organelle, the method comprising: introducing a DNA fixing template into a mitochondria or organelle comprising a target DNA in the genome of the mitochondria or organelle, such that the DNA fixing template replaces the target DNA, and optionally selecting or screening for a phenotype of an eukaryotic cell comprising the mitochondria or organelle, wherein the DNA fixing template causes the phenotype.
    Type: Application
    Filed: May 20, 2019
    Publication date: January 16, 2020
    Applicant: The Regents of the University of California
    Inventors: Itay Budin, Amanda R. Reider Apel, Niklas F.C. Hummel, Aindrila Mukhopadhyay, Jay D. Keasling
  • Publication number: 20190382802
    Abstract: The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
    Type: Application
    Filed: August 28, 2019
    Publication date: December 19, 2019
    Inventors: Jay D. Keasling, James Kirby, Eric M. Paradise
  • Patent number: 10494625
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: December 3, 2019
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Publication number: 20190345462
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Application
    Filed: January 24, 2019
    Publication date: November 14, 2019
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Publication number: 20190338321
    Abstract: The present invention provides for a genetically modified host cell capable of producing a lactam comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.
    Type: Application
    Filed: December 6, 2018
    Publication date: November 7, 2019
    Applicant: The Regents of the University of California
    Inventors: Jingwei Zhang, Jay D. Keasling
  • Publication number: 20190330663
    Abstract: The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 31, 2019
    Applicants: The Regents of the University of California, National Technology & Engineering Solutions of Sandia, LLC, BATTELLE MEMORIAL INSTITUTE (FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NATIONAL LABORATORY)
    Inventors: John M. Gladden, Jeffrey M. Skerker, Jay D. Keasling, James Kirby, Junko Yaegashi
  • Publication number: 20190309331
    Abstract: The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ?,?-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).
    Type: Application
    Filed: May 28, 2019
    Publication date: October 10, 2019
    Applicant: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • Patent number: 10435717
    Abstract: The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: October 8, 2019
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, James Kirby, Eric M. Paradise
  • Publication number: 20190300888
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Application
    Filed: May 10, 2019
    Publication date: October 3, 2019
    Applicant: The Regents of the University of California
    Inventors: Jay D. KEASLING, Leo D'ESPAUX, Jeff WONG, Xiaozhou LUO, Michael REITER, Charles DENBY, Anna LECHNER