Patents by Inventor Jay D. Keasling

Jay D. Keasling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250084446
    Abstract: An engineered pathway for carbon fixation without rubisco incorporates carbon dioxide into fructose-6-phosphate.
    Type: Application
    Filed: November 10, 2024
    Publication date: March 13, 2025
    Applicant: The Regents of the University of California
    Inventors: Jay D. Keasling, Christopher B. Eiben
  • Patent number: 12215327
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Grant
    Filed: November 14, 2022
    Date of Patent: February 4, 2025
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
  • Patent number: 12188073
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: January 7, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Publication number: 20240425891
    Abstract: The present invention provides for a genetically modified host cell reduced for expression of one of more endogenous enzyme(s) which enable the catabolism of propionyl-CoA and/or methylmalonyl-CoA, and comprising a methylmalonyl-CoA-dependent polyketide synthase (PKS).
    Type: Application
    Filed: June 21, 2024
    Publication date: December 26, 2024
    Inventors: Robert W. Haushalter, Chunjun Zhan, Jay D. Keasling
  • Patent number: 12129493
    Abstract: The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: October 29, 2024
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jing Huang, Zhennan Liu, Douglas S. Clark, Jay D Keasling, Aindrila Mukhopadhyay, John F. Hartwig
  • Publication number: 20240352498
    Abstract: The present invention relates inter alia to methods of biosynthetic production of QS-21, precursors and variants thereof, and to related aspects.
    Type: Application
    Filed: June 24, 2024
    Publication date: October 24, 2024
    Applicants: The Regents of the University of California, Plant Bioscience Limited
    Inventors: Yuzhong Liu, Samantha Aiko Crowe, Jay D. Keasling, Xiaoyue Chen, Graham Arthur Hudson, Fei Gan, Henrik V. Scheller, James Reed, Laetitia Martin
  • Publication number: 20240206515
    Abstract: Food compositions that mimic flavors and texture of animal meats are made from an edible filamentous fungus genetically engineered to overexpress heme biosynthesis genes to elevate heme levels.
    Type: Application
    Filed: February 5, 2024
    Publication date: June 27, 2024
    Applicant: The Regents of the University of California
    Inventors: Jay D. Keasling, Vayu Maini Rekdal
  • Publication number: 20240093245
    Abstract: The present invention provides for a method for producing hydrogen peroxide comprising: (a) contacting a methanol with a methanol oxidase bound with a flavin adenine dinucleotide (FAD) cofactor, such that the methanol is oxidized into a formaldehyde and the FAD cofactor is reduced into FADH2; (b) contacting the formaldehyde with the methanol oxidase or a formate oxidase bound with a FAD cofactor, such that the formaldehyde is oxidized into a formate and the FAD is reduced into FADH2; and (c) contacting oxygen with one or more of the FADH2 to produce hydrogen peroxide and oxidize FADH2 into FAD. The present invention also provides for a fusion protein comprising any two or all of methanol oxidase, formate oxidase, and formaldehyde dismutase.
    Type: Application
    Filed: April 11, 2022
    Publication date: March 21, 2024
    Applicant: The Regents of the University of California
    Inventors: Christopher B. Eiben, Jay D. Keasling
  • Publication number: 20240060101
    Abstract: SYSTEMS AND METHODS OF MAKING OIL FROM MICROORGANISMS Described herein are systems and methods of manufacturing an oil comprising a triacylglyceride. The systems and methods may comprise: (a) providing an oleaginous microorganism; (b) culturing the oleaginous microorganism in a medium comprising a carbon source, wherein the carbon source comprises ethanol at greater than 50% by weight; and (c) harvesting the oil from the oleaginous microorganism when the oil is at least 25% by weight of the oleaginous microorganism.
    Type: Application
    Filed: August 18, 2023
    Publication date: February 22, 2024
    Inventors: Jeff NOBBS, Jay D. KEASLING, Stephen B. DEL CARDAYRE
  • Publication number: 20240000863
    Abstract: A topical, skin probiotic formulation comprises a living population of Corynebacterium glutamicum bacteria genetically-engineered to produce a skin-bioactive agent, and a nutrient source for the bacteria.
    Type: Application
    Filed: August 29, 2023
    Publication date: January 4, 2024
    Applicant: The Regents of the University of California
    Inventors: Amin Zargar, Jay D. Keasling
  • Publication number: 20230340506
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Application
    Filed: November 14, 2022
    Publication date: October 26, 2023
    Applicant: The Regents of the University of California
    Inventors: Jay D. KEASLING, Leo D′ESPAUX, Jeff WONG, Xiaozhou LUO, Michael REITER, Charles DENBY, Anna LECHNER
  • Patent number: 11746336
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: September 5, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Publication number: 20230138178
    Abstract: The present invention provides for a genetically modified gut bacterial cell capable of producing an antiviral compound. The genetically modified gut bacterial cell can be introduced to a subject to colonize the gastrointestinal tract of the subject, produce the antiviral compound and increase resistance to a virus infection.
    Type: Application
    Filed: June 24, 2022
    Publication date: May 4, 2023
    Applicant: The Regents of the University of California
    Inventors: Michael Cronce, Jeffrey S. Cox, Jay D. Keasling
  • Publication number: 20230124115
    Abstract: Polyketide synthases are engineered to produce lactones. In the first module, an acyltransferase is swapped and in the second module a reductive loop is swapped. With another acyltransferase swap in the second module, we can programmably produce the non-methylated delta lactone.
    Type: Application
    Filed: November 7, 2022
    Publication date: April 20, 2023
    Inventors: Jay D. KEASLING, Amin ZARGAR
  • Publication number: 20230039548
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Application
    Filed: June 21, 2022
    Publication date: February 9, 2023
    Applicant: The Regents of the University of California
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Patent number: 11542512
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: January 3, 2023
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Leo D'Espaux, Jeff Wong, Xiaozhou Luo, Michael Reiter, Charles Denby, Anna Lechner
  • Patent number: 11505791
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: November 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Andrew Hagen, Leonard Katz, Jay D. Keasling, Sean Poust, Jingwei Zhang, Sergey Zotchev
  • Patent number: 11505810
    Abstract: This present invention provides for a genetically modified host cell, or a cell-free reaction system, and related methods and materials for the biocatalytic production of an alkyl lactones from a hydroxy fatty acid, or natural alkyl lactones and esters from sugars using non-natural combinations of enzymes.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: November 22, 2022
    Assignee: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • Publication number: 20220228180
    Abstract: Herein are provided microbial factories, in particular yeast factories, for production of strictosidine aglycone and optionally other plant-derived compounds. Also provided are methods for producing strictosidine aglycone in a microorganism, as well as useful nucleic acids, vectors and host cells.
    Type: Application
    Filed: May 13, 2020
    Publication date: July 21, 2022
    Applicant: DANMARKS TEKNISKE UNIVERSITET
    Inventors: Michael Krogh Jensen, Jay D. Keasling, Jie Zhang, Lea Gram Hansen
  • Patent number: 11384367
    Abstract: The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: July 12, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NATIONAL TECHNOLOGY AND ENGINEERING SOLUTIONS OF SANDIA, LLC, BATTELLE MEMORIAL INSTITUTE (FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NATIONAL LABORATORY)
    Inventors: John M. Gladden, Jeffrey M. Skerker, Jay D. Keasling, James Kirby, Junko Yaegashi