Patents by Inventor Jay D. Keasling

Jay D. Keasling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of bioproducts from lignin-derived aromatics by genetically modified microorganisms
    Publication number: 20190330663
    Abstract: The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.
    Type: Application
    Filed: June 24, 2019
    Publication date: October 31, 2019
    Applicants: The Regents of the University of California, National Technology & Engineering Solutions of Sandia, LLC, BATTELLE MEMORIAL INSTITUTE (FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NATIONAL LABORATORY)
    Inventors: John M. Gladden, Jeffrey M. Skerker, Jay D. Keasling, James Kirby, Junko Yaegashi
  • Host cells and methods for producing diacid compounds
    Publication number: 20190309331
    Abstract: The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ?,?-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).
    Type: Application
    Filed: May 28, 2019
    Publication date: October 10, 2019
    Applicant: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • Genetically modified host cells and use of same for producing isoprenoid compounds
    Patent number: 10435717
    Abstract: The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: October 8, 2019
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, James Kirby, Eric M. Paradise
  • MICROORGANISMS AND METHODS FOR PRODUCING CANNABINOIDS AND CANNABINOID DERIVATIVES
    Publication number: 20190300888
    Abstract: The present disclosure provides genetically modified host cells that produce a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative. The present disclosure provides methods of synthesizing a cannabinoid, a cannabinoid derivative, a cannabinoid precursor, or a cannabinoid precursor derivative.
    Type: Application
    Filed: May 10, 2019
    Publication date: October 3, 2019
    Applicant: The Regents of the University of California
    Inventors: Jay D. KEASLING, Leo D'ESPAUX, Jeff WONG, Xiaozhou LUO, Michael REITER, Charles DENBY, Anna LECHNER
  • Yeast cell modified to overproduce fatty acid and fatty acid-derived compounds
    Patent number: 10370686
    Abstract: The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the ?-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and ?-oxidation enzymes POX1, POX2, and POX3).
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: August 6, 2019
    Assignee: The Regents of the University of California
    Inventors: Weerawat Runguphan, Jay D. Keasling
  • Host cells and methods for producing diacid compounds
    Patent number: 10351881
    Abstract: The present invention provides for a genetically modified host cell and related methods and materials for the biocatalytic production of an ?,?-dicarboxylic acids (DCAs) and/or mono-methyl ester derivatives of dicarboxylic acids (DCAMMEs).
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: July 16, 2019
    Assignee: The Regents of the University of California
    Inventors: Robert W. Haushalter, Jay D. Keasling
  • USE OF PROKARYOTIC TRANSCRIPTIONAL ACTIVATORS AS METABOLITE BIOSENSORS IN EUKARYOTIC CELLS
    Publication number: 20190185865
    Abstract: The present invention relates to the use of transcriptional activators from prokaryotic organisms for use in eukaryotic cells, such as yeast as sensors of intracellular and extracellular accumulation of a ligand or metabolite specifically activating this transcriptional activator in a eukaryot, such as yeast cell, such as a cell engineered to produce this ligand. The transcriptional activator controls a promoter upstream of one or more gene, which may include e.g. a reporter gene that may be a fluorescence marker, such as luciferase, green fluorescent protein or a gnee encoding antibiotic resistance.
    Type: Application
    Filed: July 6, 2017
    Publication date: June 20, 2019
    Applicant: Danmarks Tekniske Universitet
    Inventors: Michael Krogh JENSEN, Jay D. KEASLING, Mette Louise SKJOEDT, Tim SNOEK
  • Synthetic polypeptide having a xylose import activity
    Patent number: 10316068
    Abstract: This disclosure provides methods and compositions related to microbial gene expression. In one aspect, a synthetic polypeptide having a xylose import activity.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: June 11, 2019
    Assignee: The Regents of the University of California
    Inventors: Aindrila Mukhopadhyay, Amanda Reider Apel, Mario Ouellet, Jay D. Keasling
  • Yeast Host Cells and Methods for Producing Fatty Alcohols
    Publication number: 20190136266
    Abstract: The present invention provides for a genetically modified yeast cell comprising at least six or more of the following modifications: increased expression of Mus musculus fatty acid reductase, acetyl-CoA carboxylase, fatty acid synthase 1, fatty acid synthase 2, a mutant of the bottleneck enzyme encoded by ACC1 insensitive to post-transcriptional and post-translational repression, and/or a desaturase encoded by OLE1, and reduced expression of DGA1, HFD1, ADH6, and/or GDH1. The present invention provides a method for constructing the genetically modified yeast cell, and a method for producing a fatty alcohol from the genetically modified yeast cell.
    Type: Application
    Filed: May 14, 2018
    Publication date: May 9, 2019
    Applicant: The Regents of the University of California
    Inventors: Leopold D'Espaux, Jay D. Keasling
  • Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
    Patent number: 10233431
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: March 19, 2019
    Assignee: The Regents of the University of California
    Inventors: Satoshi Yuzawa, Leonard Katz, Jay D. Keasling
  • Host cell modified to produce 2-pyrrolidone
    Patent number: 10227622
    Abstract: The present invention provides for a genetically modified host cell comprising a 2-pyrrolidone synthase, or an enzymatically active fragment thereof, heterologous to the host cell.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 12, 2019
    Assignee: The Regents of the University of California
    Inventors: Jingwei Zhang, Jay D. Keasling
  • Heterologous pathway to produce terpenes
    Patent number: 10167488
    Abstract: Cells comprising a heterologous metabolic pathway are configured to produce a terpene product containing non-multiples of five carbon, particularly wherein the pathway comprises heterologous Lepidoptera insect juvenile hormone biosynthetic pathway enzymes of the insect's mevalonate pathway.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: January 1, 2019
    Assignee: The Regents of the University of California
    Inventors: Jay D. Keasling, Christopher B. Eiben
  • MONOTERPENE-PRODUCING GENETICALLY MODIFIED HOST CELLS AND METHODS OF USE OF SAME
    Publication number: 20180327733
    Abstract: The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).
    Type: Application
    Filed: December 9, 2016
    Publication date: November 15, 2018
    Inventors: Charles M. Denby, Jay D. Keasling, James Kirby, Rachel Alexandra Li
  • Producing Adipic Acid and Related Compounds Using Hybrid Polyketide Synthases
    Publication number: 20180273930
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing a carboxylic acid, said PKS comprising a synthetic or hybrid module. The present invention also provides for a host cell comprising the PKS and when cultured produces the carboxylic acid. In some embodiments, the carboxylic acid is adipic acid.
    Type: Application
    Filed: January 10, 2018
    Publication date: September 27, 2018
    Applicant: The Regents of the University of California
    Inventors: Andrew R. Hagen, Sean Poust, Leonard Katz, Jay D. Keasling
  • Heterologous Pathway to Produce Terpenes
    Publication number: 20180119176
    Abstract: Cells comprising a heterologous metabolic pathway are configured to produce a terpene product containing non-multiples of five carbon, particularly wherein the pathway comprises heterologous Lepidoptera insect juvenile hormone biosynthetic pathway enzymes of the insect's mevalonate pathway.
    Type: Application
    Filed: November 3, 2017
    Publication date: May 3, 2018
    Applicant: The Regents of the University of California
    Inventors: Jay D. Keasling, Christopher B. Eiben
  • Host cells and methods for producing diacid compounds
    Patent number: 9951345
    Abstract: The present invention provides for a method of producing one or more fatty acid derived dicarboxylic acids in a genetically modified host cell which does not naturally produce the one or more derived fatty acid derived dicarboxylic acids. The invention provides for the biosynthesis of dicarboxylic acid ranging in length from C3 to C26. The host cell can be further modified to increase fatty acid production or export of the desired fatty acid derived compound, and/or decrease fatty acid storage or metabolism.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: April 24, 2018
    Assignee: The Regents of the University of California
    Inventors: Eric J. Steen, Jeffrey L. Fortman, Jeffrey A. Dietrich, Jay D. Keasling
  • Growth arrested cells useful for producing compounds
    Patent number: 9902964
    Abstract: The present invention provides for a genetically modified host cell in a growth-arrested state producing an antibiotic.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: February 27, 2018
    Assignee: The Regents of the University of California
    Inventors: Gregory E. Bokinsky, Jay D. Keasling
  • GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS
    Publication number: 20180030481
    Abstract: The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
    Type: Application
    Filed: October 2, 2017
    Publication date: February 1, 2018
    Inventors: Jay D. Keasling, James Kirby, Eric M. Paradise
  • Producing alpha-olefins using polyketide synthases
    Patent number: 9856461
    Abstract: The present invention provides for a polyketide synthase (PKS) capable of synthesizing an ?-olefin, such as 1-hexene or butadiene. The present invention also provides for a host cell comprising the PKS and when cultured produces the ?-olefin.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: January 2, 2018
    Assignee: The Regents of the University of California
    Inventors: Jeffrey L. Fortman, Leonard Katz, Eric J. Steen, Jay D Keasling
  • Nucleic acids encoding synthetic scaffolds and host cells genetically modified with the nucleic acids
    Patent number: 9856460
    Abstract: The present invention provides methods of producing a product or product precursor of a biosynthetic pathway in a genetically modified host cell. The present invention also provides genetically modified host cells comprising nucleic acids encoding a scaffold polypeptide and nucleic acids comprising nucleotide sequences encoding two or more enzymes in a biosynthetic pathway. The present invention further provides nucleic acids comprising nucleotide sequences encoding scaffold polypeptides, for use in a subject method.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 2, 2018
    Assignee: The Regents of the University of California
    Inventors: John E. Dueber, Jay D. Keasling, Gabriel C. Wu, Ghulam Reza K. Malmirchegini