Abstract: Hemodynamic monitoring system is presented. In one embodiment, a system for non-invasive monitoring of a subject's heart includes an RF transmitting antenna. The RF transmitting antenna is configured for transmitting at least one transmitted RF signal toward the subject. The system also includes an RF receiving antenna. The RF receiving antenna is configured for receiving at least one received RF signal transmitted by the RF transmitting antenna and modified by a subject's body. The RF transmitting antenna and the RF receiving antenna are located on opposing sides of a planar projection of the subject's heart. The system also includes a processing circuit configured for: controlling transmitting and receiving of the RF signal, and determining, based on the at least one received RF signal, at least one physiological parameter of the subject.

Abstract: The present disclosure provides methods and lubricant blends for increasing lubricity of a brine-based drilling fluid having an alkaline pH and a threshold divalent cation concentration. An embodiment of the methods herein comprise providing a produced water or a brine having a threshold divalent cation concentration and an alkaline pH; adding to the produced water or brine at least one source of free fatty acids; and optionally further adding a dispersant. Also provided are brine-based drilling fluids produced by the methods and lubricant blends disclosed herein. Also, provided are methods for improving lubricity in a wellbore during drilling operations, which comprise, combining in a modulated manner, a quantity of a produced water or brine and a quantity of a lubricant blend comprising at least one source of free fatty acids and a dispersant, to target formation of a semi-solid lubricant that adheres to downhole surfaces.

Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

Abstract: An HVAC controller controlled in response to a natural language audio message that is not recognizable by the HVAC controller as a command, where the natural language audio message is translated into a command recognizable by the HVAC controller. The HVAC controller may be a thermostat and may include a housing that at least partially houses a control module, a microphone, a speaker, a display, and a voice recognition module. The voice recognition module recognizes a predetermined audible trigger from a recorded voice message or streamed voice message, and in response, provide one or more audio clips via the speaker and/or video clips via the display to assist users in operating the thermostat. A user may communicate with the thermostat via the thermostat and/or a remote device.

Abstract: Particular aspects provide for use of the ?-herpesvirus Cytomegalovirus (CMV: e.g., RhCMV and HCMV) as a uniquely evolved “vector” for safely initiating and indefinitely maintaining high level cellular and humoral immune responses (against, e.g., HIV, SIV, TB, etc.). Particular aspects provide a method for treatment or prevention of, e.g., HIV, SIV or TB, comprising infection of a subject in need thereof with at least one recombinant CMV-based vector (e.g., HCMV or RhCMV) comprising an expressible HIV/SIV/TB antigen or a variant or fusion protein thereof. In particular embodiments of the method, infection is of an to immunocompetent, HCMV or RhCMV seropositive subject. Additional aspects provide for RhCMV- and HCMV-based vaccine vectors, and versions thereof with suicide or safety means. Further aspects provide pharmaceutical compositions comprising the inventive CMV-based vaccine vectors.

Abstract: CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV are provided. Immunization with CMV vectors having the described features allows selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.

Abstract: The present disclosure relates to recombinant rhesus cytomegalovirus (RhCMV) and human cytomegalovirus (HCMV) vectors encoding heterologous antigens, such as pathogen-specific antigens or tumor antigens, which may be used, for example, for the treatment or prevention of infectious disease or cancer. The recombinant RhCMV or HCMV vectors elicit and maintain high level cellular immune responses specific for the heterologous antigen while including deletions in one or more genes essential or augmenting for CMV replication, dissemination or spread.

Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

Abstract: Particular aspects provide for use of the ?-herpesvirus Cytomegalovirus (CMV: e.g., RhCMV and HCMV) as a uniquely evolved “vector” for safely initiating and indefinitely maintaining high level cellular and humoral immune responses (against, e.g., HIV, SIV, TB, etc.). Particular aspects provide a method for treatment or prevention of, e.g., HIV, SIV or TB, comprising infection of a subject in need thereof with at least one recombinant CMV-based vector (e.g., HCMV or RhCMV) comprising an expressible HIV/SIV/TB antigen or a variant or fusion protein thereof. In particular embodiments of the method, infection is of an immunocompetent, HCMV or RhCMV seropositive subject. Additional aspects provide for RhCMV- and HCMV-based vaccine vectors, and versions thereof with suicide or safety means. Further aspects provide pharmaceutical compositions comprising the inventive CMV-based vaccine vectors.

Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

Abstract: Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.

Abstract: A method of controlling an HVAC system can include receiving audio that includes a predefined trigger phrase followed by a voice command to change a set point temperature of the HVAC system to a requested set point value, converting the audio into a natural language audio stream, identifying the predefined trigger phrase in the natural language audio stream, transmitting a part of the natural language audio stream that includes the voice command to a remote web service for identifying the voice command therein, receiving a first building control device command generated by and from the remote web service at a building control device when the requested set point value is within a predetermined range, and receiving a second building control command generated by and from the remote web service at the building control device when the requested set point value is outside of the predetermined range.

Abstract: An HVAC controller may be controlled in response to a natural language audio message that is not recognizable by the HVAC controller as a command, where the natural language audio message is translated into a command recognizable by the HVAC controller. The HVAC controller may be a thermostat and may include a housing that at least partially houses a control module, a microphone, a speaker, a display, and a voice recognition module. The voice recognition module recognizes a predetermined audible trigger from a recorded voice message or streamed voice message, and in response, provide one or more audio clips via the speaker and/or video clips via the display to assist users in operating the thermostat. A user may communicate with the thermostat via the thermostat and/or a remote device.

Abstract: Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.

Abstract: Disclosed herein are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an active UL128 protein and an active UL130 protein. Also disclosed are recombinant CMV vectors comprising heterologous antigens and microRNA recognition elements to silence expression of CMV genes in the presence of microRNA derived from myeloid cells, an inactive UL128 protein and an inactive UL130 protein. Also disclosed are methods of generating an unconventional immune response using these vectors. Such an immune response is characterized by generation of a CD8+ T cell response that is predominantly restricted by MHC-II.

Abstract: An HVAC controller controllable in response to a natural language audio message that is not recognizable by the HVAC controller as a command, where the natural language audio message is translated into a command recognizable by the HVAC controller. The HVAC controller may be a thermostat and may include a housing that at least partially houses a control module, a microphone, a speaker, a display, and a voice recognition module. The voice recognition module recognizes a predetermined audible trigger from a recorded voice message or streamed voice message, and in response, provide one or more audio clips via the speaker and/or video clips via the display to assist users in operating the thermostat. A user may communicate with the thermostat via the thermostat and/or via a remote device.

Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

Abstract: Disclosed are CMV vectors that lack active UL128, UL130, UL146 and UL147 proteins that may also comprise one or more microRNA regulatory elements (MRE) that restrict expression of the CMV. Immunization with the disclosed CMV vectors allow selection of different CD8+ T cell responses—CD8+ T cells restricted by MHC-Ia, MHC-II, or by MHC-E.

Abstract: Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

Abstract: A mechanism for control and configuration of a lighting system from a user interface. For instance, a wall module designed as a user interface for a tenant to control the system may be implemented so as to be used not only to control the lighting system but also to configure it. The lighting system may involve a controller, circuits of lights, relays, motion and ambient detectors, scenes, schedules, and more. An additional user interface such as a wall module may be connected to the lighting system for control and configuration of the system.