Abstract: The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation.

Abstract: The present invention provides an improved fiber-reinforced article comprised of at least two plies. Each of the plies comprises (a) rubber and (b) cord made from melt-spinnable, non-metallic, multifilament fibers for which the cord has a twist multiplier of less than or equal to about 375, a stress at 1% strain greater than or equal to about 1.7 grams/denier, and an initial compressive modulus greater than or equal to about 7 grams/denier, and the at least two plies have a fiber orientation angle of greater than or equal to about 23°. The composite is useful as a tire belt in a passenger tire.

Abstract: A spun polyester fiber, a drawn polyester yarn, and methods for making them. Polyethylene terephthalate yarn is prepared by extruding a molten melt-spinnable polyethylene terephthalate having an intrinsic viscosity of at least about 0.8 through a shaped extrusion orifice having a plurality of openings to form a molten spun yarn; solidifying gradually said molten spun yarn by passing said molten spun yarn through a solidification zone which comprises (i) a retarded cooling zone and (ii) a cooling zone adjacent said retarded cooling zone where, in said cooling zone, said yarn is rapidly cooled and solidified in a gaseous atmosphere; withdrawing at sufficient speed said solidified yarn from said solidification zone to form a crystalline partially oriented yarn; and hot drawing said crystalline partially oriented yarn at a total draw ratio between about 1.5/1 and about 2.

Abstract: We have developed a process and product which provide thermoplastic articles featuring a permanent outer surface which has selectively varied chemical functionality while maintaining the inherent mechanical properties of the base fiber.

Abstract: We have developed a process and product which provide thermoplastic articles featuring a permanent outer surface which has selectively varied chemical functionality while maintaining the inherent mechanical properties of the base fiber.

Abstract: Polyethylene terephthalate yarn is prepared by spinning under high stress conditions in the transition region between oriented-amorphous and oriented-crystalline undrawn yarns by selection of process parameters to form an undrawn yarn that is a crystalline, partially oriented yarn with a crystallinity of 3 to 15 percent and a melting point elevation of 2 to 10° C. The spun yarn is then hot drawn to a total draw ratio between 1.5/1 and 2.5/1 with the resulting properties: (A) a terminal modulus of at least 20 g/d, (B) a dimensional stability defined by E4.5+FS<13.5 percent, (C) a tenacity of at least 7 grams per denier, (D) a melting point elevation of 9 to 14° C., and (E) an amorphous orientation function of less than 0.75. The resulting treated tire cord provides high tenacity in combination with improved dimensional stability.

Abstract: The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation.

Abstract: Polyethylene terephthalate yarn is prepared by spinning under high stress conditions in the transition region between oriented-amorphous and oriented-crystalline undrawn yarns by selection of process parameters to form an undrawn yarn that is a crystalline, partially oriented yarn with a crystallinity of 3 to 15 percent and a melting point elevation of 2 to 10° C. The spun yarn is then hot drawn to a total draw ratio between 1.5/1 and 2.5/1 with the resulting properties: (A) a terminal modulus of at least 20 g/d, (B) a dimensional stability defined by E4.5+FS<13.5 percent, (C) a tenacity of at least 7 grams per denier, (D) a melting point elevation of 9 to 14° C., and (E) an amorphous orientation function of less than 0.75. The resulting treated tire cord provides high tenacity in combination with improved dimensional stability.

Abstract: A vertical impact testing apparatus comprises a rigid frame, an anvil connected to the frame, a dart positioned above the anvil, and a dropped-weight mechanism slidably connected to the frame. The frame is comprised of a vertical column, a base, and a guide rail. The vertical column extends for a sufficient distance to securely support a weight assembly through travel from various heights for testing a specimen. To facilitate downward travel of the dropped-weight mechanism at a proper vertical orientation, a guide block is rigidly attached to the weight assembly and the dropped-weight mechanism is slidably mounted to the guide rail. The dart is stabilized by a braced support arm connected to the frame and a bearing acting cooperatively to ensure impact of the dart with the specimen is in the vertical plane and without tilt. The anvil is a solid structure, fixed in position, which contacts and supports the specimen on a side opposite of the dart as the dart impacts the substrate and forces it downward.

Abstract: Polyethylene terephthalate yarn is prepared by spinning under high stress conditions in the transition region between oriented-amorphous and oriented-crystalline undrawn yarns by selection of process parameters to form an undrawn yarn that is a crystalline, partially oriented yarn with a crystallinity of 3 to 15 percent and a melting point elevation of 2 to 10° C. The spun yarn is then hot drawn to a total draw ratio between 1.5/1 and 2.5/1 with the resulting properties: (A) a terminal modulus of at least 20 g/d, (B) a dimensional stability defined by E4.5+FS<13.5 percent, (C) a tenacity of at least 7 grams per denier, (D) a melting point elevation of 9 to 14° C., and (E) an amorphous orientation function of less than 0.75. The resulting treated tire cord provides high tenacity in combination with improved dimensional stability.

Abstract: There is disclosed an assay system for determining therapeutic activity for treating restenosis, atherosclerosis, chronic rejection syndrome and graft versus host disease (GVHD) by measuring inhibition of cell migration activity in smooth muscle cells expressing a US28 receptor from the CMV genome. Specifically, there is disclosed a method for measuring inhibition of cell migration in isolated cells transfected with US28 or infected with CMV and stimulated with a ligand. There is further disclosed a method for treating atherosclerosis, restenosis, chronic rejection syndrome and graft versus host disease (GVHD), comprising administering an effective amount of an agent that is a US28 receptor antagonist, wherein a US28 receptor antagonist comprises an inhibitor compound that prevents transduction of US28 receptor signal stimulated by a US28 receptor ligand, wherein a US28 receptor ligand is selected from the group consisting of RANTES, MIP-1&agr; and MCP.

Abstract: We have developed a process and product which provide thermoplastic articles featuring a permanent outer surface which has selectively varied chemical functionality while maintaining the inherent mechanical properties of the base fiber.

Abstract: There is disclosed an assay system for determining therapeutic activity for treating restenosis, atherosclerosis, chronic rejection syndrome and graft versus host disease (GVHD) by measuring inhibition of cell migration activity in smooth muscle cells expressing a US28 receptor from the CMV genome. Specifically, there is disclosed a method for measuring inhibition of cell migration in isolated cells transfected with US28 or infected with CMV and stimulated with a ligand. There is further disclosed a method for treating atherosclerosis, restenosis, chronic rejection syndrome and graft versus host disease (GVHD), comprising administering an effective amount of an agent that is a US28 receptor antagonist, wherein a US28 receptor antagonist comprises an inhibitor compound that prevents transduction of US28 receptor signal stimulated by a US28 receptor ligand, wherein a US28 receptor ligand is selected from the group consisting of RANTES, MIP-1&agr; and MCP.

Abstract: Polyethylene terephthalate yarn is prepared by spinning under high stress conditions in the transition region between oriented-amorphous and oriented-crystalline undrawn yarns by selection of process parameters to form an undrawn yarn that is a crystalline, partially oriented yarn with a crystallinity of 3 to 15 percent and a melting point elevation of 2 to 10° C. The spun yarn is then hot drawn to a total draw ratio between 1.5/1 and 2.5/1 with the resulting properties: (A) a terminal modulus of at least 20 g/d, (B) a dimensional stability defined by E4.5+FS<13.5 percent, (C) a tenacity of at least 7 grams per denier, (D) a melting point elevation of 9 to 14° C., and (E) anamorphous orientation function of less than 0.75. The resulting treated tire cord provides high tenacity in combination with improved dimensional stability.

Abstract: Polyethylene terephthalate yarn is prepared by spinning under high stress conditions in the transition region between oriented-amorprhous and oriented-crystalline undrawn yarns by selection of process parameters to form an undrawn yarn that is a crystalline, partially oriented yarn with a crystallinity of 3 to 15 percent and a melting point elevation of 2 to 10° C. The spun yarn is then hot drawn to a total draw ratio between 1.5/1 and 2.5/1 with the resulting properties: (A) a terminal modulus of at least 20 g/d, (B) a dimensional stability defined by E4.5+FS<13.5 percent, (C) a tenacity of at least 7 grams per denier, (D) a melting point elevation of 9 to 14° C., and (E) an amorphous orientation function of less than 0.75. The resulting treated tire cord provides high tenacity in combination with improved dimensional stability.

Abstract: The present invention provides methods of latent virus reactivation in monocyte-derived macrophages through allogeneic stimulation of peripheral blood mononuclear cells (“PBMC”), methods of culturing virus, and cultures of virally permissive monocyte-derived macrophages.

Abstract: The present invention provides methods of latent virus reactivation in monocyte-derived macrophages through allogeneic stimulation of peripheral blood mononuclear cells (“PBMC”), methods of culturing virus, and cultures of virally permissive monocyte-derived macrophages.

Abstract: There is provided a method of improving the properties of polyester monofilaments in respect to loop strength and resistance to fibrillation. The process contemplates treating an undrawn substantially noncrystalline extensible spun linear polyethylene terephthalate monofilament with a vapor medium such as steam and, while the monofilament is exposed to such vapor, drawing the monofilament at a draw ratio of from 1.5:1 to 4:1 and further drawing the monofilament in a subsequent drawing operation to an aggregate draw ratio of from 4:1 to 10:1.The process enables development of the maximum or a desired loop strength value for the particular monofilament being processed with optimization of specific drawing conditions such as the steam pressure within the indicated draw ratios. Thus, drawn monofilaments having loop strength values of at least 2.5 grams/denier are provided, and the drawn products are particularly useful as reinforcing elements in rubber bodies, e.g. tire cords.