Patents by Inventor Jean Georges

Jean Georges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6207657
    Abstract: The invention concerns steroid compounds of general formula (I) in which n=2, 3, either R1 and R2═H, (C1-C4) alkyl, or R1 and R2 form with nitrogen a heterocyclic compound, X═OH optionally esterified, Y═(C1-C4)alkyl, and their additive salts, the method for preparing them, their application as medicine and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: March 27, 2001
    Assignee: Hoechst Marion Roussel
    Inventors: Yamina Bouali, Francois Nique, Jean-Georges Teutsch, Patrick Van De Velde
  • Patent number: 6138615
    Abstract: A device improving the combustion of a fuel by a gaseous oxidant includes a fuel intake, an oxidant intake and apparatus for keeping naphthalene in solid form in the gaseous oxidant intake to load it with naphthalene vapors as it flows towards the combustion chamber. The apparatus for keeping the naphthalene in the gaseous oxidant current includes a cartridge filled with naphthalene and having apertures forcing the oxidant gas to pass through it directly along a direction coinciding with that of the flow of the oxidant gas to the combustion chamber.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: October 31, 2000
    Inventors: Jean-Louis Boisset, Patrick Jean Georges Siegler-Lathrop
  • Patent number: 6087509
    Abstract: A particular subject of the invention is the products of formula (I): ##STR1## in which: R.sub.1 and R.sub.2 represent in particular cyano and trifluoromethyl,R.sub.3 represents in particular alkyl, alkenyl or alkynyl, optionally substituted by one or more halogen, cyano or hydroxyl radicals,R.sub.4 and R.sub.5 either represent in particular methyl optionally substituted by fluorine,or form in particular a cyclohexyl radical,X and Y represent in particular oxygen,as well as their salts and isomers.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: July 11, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Andre Claussner, Francois Goubet, Jean-George Teutsch
  • Patent number: 6011026
    Abstract: A method of treating menopause or perimenopause without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein the substituents are defined as in the specification sufficient to treat menopause or perimenopause symptoms without estrogenic activity at the uterine level.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: January 4, 2000
    Assignee: Hoeschst Marion Roussel
    Inventors: Yamina Bouali, Daniel Philibert, Francois Nique, Jean-Georges Teutsch, Patrick Van De Velde
  • Patent number: 6000772
    Abstract: The present invention relates to a DNA expression vector comprising a T.alpha.l .alpha.-tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: December 14, 1999
    Assignee: McGill University
    Inventors: Freda Diane Miller, Andrew Gloster, Carrie Grace Causing, Jean George Toma
  • Patent number: 5997665
    Abstract: A block is produced by juxtaposition and joining of at least one plate made of tool steel and of at least one plate made from mild steel. The block is hot rolled and then it is cooled to a temperature below 200.degree. C. The rolled block is tempered at a temperature above 450.degree. C. after cooling. The clad sheet obtained includes a layer made of tool steel having a tempered martensitic structure and containing primary carbides and a fine dispersion of secondary carbides.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: December 7, 1999
    Assignee: Creusot Loire Industrie
    Inventors: Jean-Georges Brisson, Jean Beguinot
  • Patent number: 5989363
    Abstract: A nitriding process and nitriding furnace therefor wherein the parts to be treated are maintained at floating potentional in a vacuum furnace (9), current being provided to a metal screen (5) cathode surrounding the parts to be treated, the necessary heat being provided by radiation from screen (5) whereby nitriding gas is injected into the furnace such that it has to flow through screen (5) where the plasma necessary for the nitriding reaction is generated by glow discharge the plasma flowing around and reacting with the parts to be treated before it is evacuated at the bottom of furnace (9) through vacuum/exhaust conduit (2).
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: November 23, 1999
    Assignee: Plasma Metal SA
    Inventor: Jean Georges
  • Patent number: 5981516
    Abstract: A method of treating cholesterol without estrogenic activity at the uterine level in women comprising administering to women an amount of a steroid of the formula ##STR1## wherein the substituents are defined as in the specification without estrogenic activity at the uterine level.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: November 9, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Yamina Bouali, Daniel Philibert, Francois Nique, Jean-Georges Teutsch, Patrick Van De Velde
  • Patent number: 5965763
    Abstract: Novel compounds of the formula ##STR1## wherein the substituents are defined as in the application and their salts with non-toxic, pharmaceutically acceptable acids and bases having 5-.alpha.-reductase inhibiting activity and a process and intermediates for their preparation.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: October 12, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Jean-Fran.cedilla.ois Gourvest, Dominique Lesuisse, Jean-Georges Teutsch
  • Patent number: 5958936
    Abstract: Novel imidazoles of the formula ##STR1## wherein the substituents are as defined in the disclosure and their non-toxic, pharmaceutically acceptable addition salts with acids and bases having antiandrogenic activity.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: September 28, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Andre Claussner, Francois Goubet, Jean-Georges Teutsch
  • Patent number: 5908710
    Abstract: A block is produced by juxtaposition and joining of at least one plate made of tool steel and of at least one plate made from mild steel. The block is hot rolled and then it is cooled to a temperature below 200.degree. C. The rolled block is tempered at a temperature above 450.degree. C. after cooling. The clad sheet obtained includes a layer made of tool steel having a tempered martensitic structure and containing primary carbides and a fine dispersion of secondary carbides.
    Type: Grant
    Filed: April 15, 1993
    Date of Patent: June 1, 1999
    Assignee: Creusot Loire Industrie
    Inventors: Jean-Georges Brisson, Jean Beguinot
  • Patent number: 5844627
    Abstract: A digital filter for noise reduction selects between local variances obtained from adjacent pixels in the same frame and adjacent pixels in the same field. In one embodiment, the digital filter includes a filter modified from an adaptive Wiener filter which preserves edges and smoothes smooth areas of the image. A high compression ratio can be achieved in very smooth regions of the image without introducing artifacts.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: December 1, 1998
    Assignee: Minerya System, Inc.
    Inventors: William May, Jean-Georges Fritsch
  • Patent number: 5827887
    Abstract: Novel compounds of the formula ##STR1## wherein the substituents are defined as in the application and their salts with non-toxic, pharmaceutically acceptable acids and bases having 5-.alpha.-reductase inhibiting activity and a process and intermediates for their preparation.
    Type: Grant
    Filed: July 31, 1996
    Date of Patent: October 27, 1998
    Assignee: Roussel Uclaf
    Inventors: Jean-Fran.cedilla.ois Gourvest, Dominique Lesuisse, Jean-Georges Teutsch
  • Patent number: 5714116
    Abstract: A steel composition useful for the manufacture of articles and components having high abrasion resistance.
    Type: Grant
    Filed: April 24, 1996
    Date of Patent: February 3, 1998
    Assignee: Creusot Loire Industrie (Societe Anonyme)
    Inventors: Jean Beguinot, Jean-Georges Brisson
  • Patent number: 5707982
    Abstract: A 19-nor-steroid having a formula selected from the group consisting of ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2##
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: January 13, 1998
    Assignee: ROUSSEL UCLAF
    Inventors: Andre Claussner, Daniel Philibert, Lucien Nedelec, Patrick Van De Velde, Francois Nique, Jean-Georges Teutsch
  • Patent number: 5705494
    Abstract: Disclosed is a method of inducing anti-estrogenic activity in warm-blooded animals by the administration of a compound of the formula ##STR1## wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: August 8, 1995
    Date of Patent: January 6, 1998
    Assignee: Roussel-Uclaf
    Inventors: Francois Nique, Jean-Georges Teutsch, Patrick Van de Velde
  • Patent number: 5705654
    Abstract: Described herein are novel imidazoles of the formula ##STR1## wherein the substituents are as defined in the disclosure and their non-toxic, pharmaceutically acceptable addition salts with acids and bases having antiandrogenic activity.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: January 6, 1998
    Assignee: Roussel Uclaf
    Inventors: Andre Claussner, Francois Goubet, Jean-Georges Teutsch
  • Patent number: 5683996
    Abstract: A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R.sub.b --NH--, Ra is an organic radical, Ri and Rj are individually selected from the group consisting of hydrogen, aliphatic hydrocarbon, aromatic hydrocarbon and heterocycle or taken together with the nitrogen atom to which they are attached form an optionally substituted ring, Rb is selected from the group consisting of carbocyclic aryl and heterocyclic aryl, both optionally substituted, R.sub.1A is selected from the group consisting of ##STR3## and ##STR4## are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z.sub.A is selected from the group consisting of a simple bond, --O-- and optionally oxidized sulfur, R.sub.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: November 4, 1997
    Assignee: Roussel UCLAF
    Inventors: Jean-Georges Teutsch, Alain Bonnet, Jozsef Aszodi, Solange Gouin D'Ambrieres
  • Patent number: 5679788
    Abstract: Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the substituents are defined in the specification.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: October 21, 1997
    Assignee: Roussel Uclaf
    Inventors: Francois Nique, Jean-Georges Teutsch, Patrick Van de Velde
  • Patent number: RE35956
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is --CN, --NO.sub.2 or halogen, R.sub.2 is --CF.sub.3 or halogen, --A--B-- is of ##STR2## X is --O-- or --S--, R.sub.3 is hydrogen, alkyl, alkenyl or alkynyl of up to 12 carbon atoms, aryl and aralkyl of up to 12 carbon atoms, all optionally substituted by --OH, halogen, --SH, --CN, acyl and acyloxy of up to 7 carbon atoms, --aryl, --O--aryl, --O--aralkyl --S-- aryl of up to 12 carbon atoms the aryl and aralkyl being optionally substituted by halogen, --CF.sub.3, alkyl, alkoxy, alkenyl, alkenyloxy, alkynyl or alkynyloxy with the sulfur being optionally oxidized to sulfone or sulfoxide, free, esterified, amidified or salified carboxy, --NH.sub.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: November 10, 1998
    Assignee: Roussel Uclaf
    Inventors: Martine Gaillard-Kelly, Francois Goubet, Daniel Phiibert, Jean-Georges Teutsch