Patents by Inventor Jean M. J. Fréchet
Jean M. J. Fréchet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7056901Abstract: Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.Type: GrantFiled: March 28, 2003Date of Patent: June 6, 2006Assignee: The Regents of the University of CaliforniaInventors: Jean M. J. Frechet, Niren Murthy
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Patent number: 6890522Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 30, 2003Date of Patent: May 10, 2005Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Patent number: 6887384Abstract: Microfluidic devices comprising porous monolithic polymer for concentration, extraction or mixing of fluids. A method for in situ preparation of monolithic polymers by in situ initiated polymerization of polymer precursors within microchannels of a microfluidic device and their use for solid phase extraction (SPE), preconcentration, concentration and mixing.Type: GrantFiled: September 20, 2002Date of Patent: May 3, 2005Assignee: The Regents of the University of CaliforniaInventors: Jean M. J. Frechet, Frantisek Svec, Cong Yu, Thomas Rohr
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Publication number: 20040242789Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.Type: ApplicationFiled: June 29, 2004Publication date: December 2, 2004Applicant: Symyx Technologies, Inc.Inventors: Mingjun Liu, Damian Hajduk, Jean M.J. Frechet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
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Patent number: 6767968Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.Type: GrantFiled: October 3, 2000Date of Patent: July 27, 2004Assignee: Symyx Technologies, Inc.Inventors: Mingjun Liu, Damian Hajduk, Jean M. J. Fréchet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
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Publication number: 20040101442Abstract: A microfluidic device preferably made of a thermoplastic polymer that includes a channel or a multiplicity of channels whose surfaces are modified by photografting. The device further includes a porous polymer monolith prepared via UV initiated polymerization within the channel, and functionalization of the pore surface of the monolith using photografting. Processes for making such surface modifications of thermoplastic polymers and porous polymer monoliths are set forth.Type: ApplicationFiled: September 19, 2003Publication date: May 27, 2004Applicant: The Regents of the University of CaliforniaInventors: Jean M.J. Frechet, Frantisek Svec, Thomas Rohr
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Patent number: 6740193Abstract: In accordance with the present invention, there are provided gem-diesters and epoxidized derivatives thereof. When cured, thermosets comprising invention gem-diesters and epoxidized derivatives thereof have thermally and/or chemically labile gem-diester groups interspersed throughout the crosslinked network. Thus, thermosets based on invention gem-diesters and epoxidized derivatives thereof can be easily reworked thermally or chemically by treatment with dilute acidic or basic solutions. Further provided by the present invention are adhesive compositions comprising invention gem-diesters and epoxidized derivatives thereof.Type: GrantFiled: December 21, 2001Date of Patent: May 25, 2004Assignee: Henkel CorporationInventors: John G. Woods, Jianzhao Wang, Jean M. J. Fréchet
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Publication number: 20040096411Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: ApplicationFiled: October 30, 2003Publication date: May 20, 2004Applicant: Unilever Home & Personal Care USA, Division of Conopco, Inc.Inventors: Jean M.J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Publication number: 20040072994Abstract: An integrated nanostructure comprises a microelectronic substrate having a surface; a catalyst disposed upon the surface of the microelectronic substrate and positioned thereupon within a first predetermined set of X and Y coordinates, wherein the catalyst is activated within a second predetermined set of X and Y coordinates defined within the surface of the microelectronic substrate; and a nanotube selectively disposed upon the activated second predetermined set of X and Y coordinates defined within the surface of the microelectronic substrate, such that the nanotube is controllably grown at a predetermined position upon the surface of the microelectronic substrate; wherein at least one selected from the group consisting of: (1) the disposition according to the first predetermined set of X and Y coordinates and (2) the activation of the catalyst according to the second predetermined set of X and Y coordinates is scaled with atomic precision.Type: ApplicationFiled: October 15, 2002Publication date: April 15, 2004Inventors: Daniel J.C. Herr, Jean M.J. Frechet
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Patent number: 6685925Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the copolymer is soluble at a level of at least 1% by weight in water at 25° C. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 3, 2001Date of Patent: February 3, 2004Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Patent number: 6673192Abstract: Primers for cyanoacrylate adhesives which are based on compounds having multiple amine groups thereon (“multi-amines”) which have at least three secondary or tertiary amine groups, at least one of which is a tertiary amine group. The multi-amine compounds are characterized by having thereon at least three terminal and/or pendant aliphatic hydrocarbon groups of at least 4 carbon atoms in length. Such primers give substantially improved bond strengths to cyanoacrylate adhesive bonded assemblies comprising a polyolefin substrate such as high density polyethylene, LDPE or polypropylene. The multi-amine may have a cascade, dendrimer, hyperbranched or comb-like structure.Type: GrantFiled: September 25, 1997Date of Patent: January 6, 2004Assignee: Loctite CorporationInventors: John G. Woods, Jean M. J. Fréchet
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Publication number: 20030232203Abstract: A composition, method and use is disclosed for a porous plug that functions as an electro-osmotic pump. The polymer eliminates any back pressure effects while enhancing the electro-osmotic flow in a channel. The pump is bach fabricated by surface micromachining on top of a silicon wafer. The pump device is driven by an alternating zero-average injected current signal at low frequencies producing a bubble-free electro-osmotic flow with a reversible net movement. The device is capable of an average water-air interface velocity of 1.8 &mgr;m/second at 0.8 Hz. The velocity may be increased from between 4.8-13.9 &mgr;m/second by necking down the channel size.Type: ApplicationFiled: January 17, 2003Publication date: December 18, 2003Applicants: The Regents Of The University Of Michigan, The Regents Of The University Of CaliforniaInventors: Senol Mutlu, Ponnambalam Selvaganapathy, Carlos Mastrangelo, Frantisek Svec, Jean M.J. Frechet, Cong Yu
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Patent number: 6663855Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: GrantFiled: October 3, 2001Date of Patent: December 16, 2003Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Jean M. J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford
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Publication number: 20030211158Abstract: Novel microgels, microparticles and related polymeric materials capable of delivering bioactive materials to cells for use as vaccines or therapeutic agents. The materials are made using a crosslinker molecule that contains a linkage cleavable under mild acidic conditions. The crosslinker molecule is exemplified by a bisacryloyl acetal crosslinker. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and sites of inflammation.Type: ApplicationFiled: March 28, 2003Publication date: November 13, 2003Inventors: Jean M.J. Frechet, Niren Murthy
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Patent number: 6616825Abstract: An electrochromatographic device is provided for conducting enantioselective separation of enantiomers. The device is comprised of a conduit containing a monolithic enantioselective separation medium, and may be, for example, a capillary tube or a microchannel in a substrate. The enantioselective separation medium is prepared by copolymerization of (a1) an ionizable chiral monomer or (a2) a chiral monomer and an ionizable comonomer, along with (b) a crosslinking comonomer and (c) a polymerization initiator, in (d) a porogenic solvent. Following ionization, the enantioselective separation medium serves as a charge carrier as well as a chiral separation medium, and further acts as an electroosmotic pump to facilitate the flow of a fluid. The invention also provides methods for preparing the enantioselective separation medium and electrochromatographic devices fabricated therewith.Type: GrantFiled: August 23, 2000Date of Patent: September 9, 2003Assignee: The Regents of the University of CaliforniaInventors: Jean M. J. Fréchet, Frantisek Svec, Michael Lämmerhofer
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Publication number: 20030157334Abstract: In accordance with the present invention, there are provided gem-diesters and epoxidized derivatives thereof. When cured, thermosets comprising invention gem-diesters and epoxidized derivatives thereof have thermally and/or chemically labile gem-diester groups interspersed throughout the crosslinked network. Thus, thermosets based on invention gem-diesters and epoxidized derivatives thereof can be easily reworked thermally or chemically by treatment with dilute acidic or basic solutions. Further provided by the present invention are adhesive compositions comprising invention gem-diesters and epoxidized derivatives thereof.Type: ApplicationFiled: December 21, 2001Publication date: August 21, 2003Applicant: Loctite CorporationInventors: John G. Woods, Jianzhao Wang, Jean M.J. Frechet
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Patent number: 6545101Abstract: Polyisobutylene (PIB) functionalized with terminal reactive unsaturation is disclosed. Carbocationically polymerized monohalogen-terminated PIB is dehydrohalogenated in a hydrocarbon solvent using an alkoxide of the formula RO-M wherein R is alkyl of at least 5 carbon atoms and M is alkali metal. The PIB obtained has terminal unsaturation which is 100% in the reactive ‘exo’ form which can be converted to succinic anhydride groups (PIB-SA) by the ene reaction with maleic anhydride. The PIB-SA is reactive with amine functional dendrimers to obtain a star-branched polymer having a dendrimer core and PIB branches joined by succinimide linkages. Blends of the star-branched polymer with polypropylene have improved energy absorption properties and controllable moisture/oxygen permeabilities useful in films.Type: GrantFiled: February 6, 2001Date of Patent: April 8, 2003Assignee: ExxonMobil Chemical Patents Inc.Inventors: Pawan Kumar Agarwal, Hsien-Chang Wang, Yu Feng Wang, Jean M. J. Frechet, Shah A. Haque
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Publication number: 20030050433Abstract: Polyisobutylene (PIB) functionalized with terminal reactive unsaturation is disclosed. Carbocationically polymerized monohalogen-terminated PIB is dehydrohalogenated in a hydrocarbon solvent using an alkoxide of the formula RO-M wherein R is alkyl of at least 5 carbon atoms and M is alkali metal. The PIB obtained has terminal unsaturation which is 100% in the reactive ‘exo’ form which can be converted to succinic anhydride groups (PIB-SA) by the ene reaction with maleic anhydride. The PIB-SA is reactive with amine functional dendrimers to obtain a star-branched polymer having a dendrimer core and PIB branches joined by succinimide linkages. Blends of the star-branched polymer with polypropylene have improved energy absorption properties and controllable moisture/oxygen permeabilities useful in films.Type: ApplicationFiled: October 23, 2002Publication date: March 13, 2003Inventors: Pawan Kumar Agarwal, Hsien-Chang Wang, Yu Feng Wang, Jean M. J. Frechet, Shah A. Haque
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Patent number: 6475391Abstract: A method is disclosed for characterizing a plurality of non-biological polymer samples. The method includes the steps of injecting four or more non-biological polymer samples into a mobile-phase of a liquid chromatography system, chromatographically separating at least one sample component or polymer molecule of each of the four or more injected polymer samples from other sample components or polymer molecules thereof in a chromatographic column, and serially detecting a property of the four or more non-biological polymer samples or of components or polymer molecules thereof with a flow-through detector at an average sample throughput of not more than about 10 minutes per sample.Type: GrantFiled: February 6, 2001Date of Patent: November 5, 2002Assignee: Symyx Technologies, Inc.Inventors: Adam Safir, Miroslav Petro, Ralph B. Nielsen, Thomas S. Lee, Jean M. J. Fréchet
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Publication number: 20020160026Abstract: Cosmetic or personal care compositions, such as for styling hair, comprise a thermoplastic elastomer which is a block copolymer comprising a core polymer having a backbone comprising at least a proportion of C—C bonds and two or more flanking polymers. Each flanking polymer is covalently bound to an end of the core polymer and the core polymer and/or at least one of the flanking polymers is a copolymer derived from two or more monomers. The compositions comprise a cosmetically acceptable diluent or carrier.Type: ApplicationFiled: October 3, 2001Publication date: October 31, 2002Applicant: Unilever Home & Personal Care USAInventors: Jean M.J. Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu, Ralph B. Nielsen, Euan Stuart Reid, Keith Leslie Rutherford