Abstract: The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.

Abstract: The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).

Abstract: A turbomachine blade formed of a hollow airfoil having a leading edge and a trailing edge opposed to each other and connected by an intrados wall and an extrados wall each extending along a radial axis of the blade, between a blade root and a blade tip, and including a cooling circuit supplied with air and delivering air jets ensuring through multiple perforations of the cooling circuit an impingement cooling of the inner surface of the airfoil, the cooling circuit includes superimposed cooling channels over the height of the blade, each integrated into the inner surface of the airfoil while matching its contour, the multiple perforations being drilled in the cooling channels terminating in a purge cavity of the airfoil are able to ensure a purge of the air having impinged the inner surface of the airfoil after its passage through the perforations.

Abstract: The present invention relates to macrocyclic pyridotriazine derivatives of formula (I) and the pharmaceutically acceptable salts, solvates or polymorph thereof, and the use of such compounds as a medicament, in particular in the prevention and/or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, and to the compositions or preparations for use as a medicament, more preferably for the prevention or treatment of viral infections caused by viruses belonging to the Orthomyxoviridae family.

Abstract: A distributed system including multiple processing nodes. The distributed system can perform certain acts. The acts can include receiving a first conflation event identifying a first node and a second node. The first node can be part of a first set. The first set can include a sole parent node stored at a first processing node of the multiple processing nodes. The second node can be part of a second set. The second set can include a sole parent node stored at a second processing node of the multiple processing nodes. The first and second sets can be disjoint sets. The first conflation event can be received at an event-driven stream application at one of the multiple processing nodes. The acts also can include conflating the first set and the second set into a conflated set. The conflated set can include the first and second nodes. The conflated set can include a sole parent node.

Abstract: Systems, methods and devices for distributed memory management comprising a network component configured for network communication with one or more memory resources that store data and one or more consumer devices that use data, the network component comprising a switching device in operative communication with a mapping resource, wherein the mapping resource is configured to associate mappings between data addresses associated with memory requests from a consumer device relating to a data object and information relating to a storage location in the one or more memory resources associated with the data from the data object, wherein each data address has contained therein identification information for identifying the data from the data object associated with that data address; and the switching device is configured to route memory requests based on the mappings.

Abstract: Root certificates generated by root certificate authorities may be bound at the time of generation. In an example, a first root certificate can include an identity of a first root certificate authority, a first key identifier associated with a first key of the first root certificate authority and an identity of a first digital signature algorithm used by the first root certificate authority. The first root certificate can also include at least one extension including a second key identifier of a second key associated with the second root certificate authority and an identity of a second digital signature algorithm used by the second root certificate authority, the second digital signature algorithm being different from the first digital signature algorithm.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial vims (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment or prevention of respiratory syncytial vims infection.

Abstract: Methods and systems for cross-certification to bind together two cryptographic systems are disclosed. One method includes receiving, from a first certificate authority at a second certificate authority, a cross certificate request, the cross certificate request including an attribute unique to the first certificate authority. The method also includes calculating a signature at the second certificate authority based at least in part on the attribute, and calculating a hash value based on a combination of the signature calculated at the second certificate authority and a key associated with the second certificate authority. The method includes generating a cross certificate and embedding the hash value as a certificate extension within the cross certificate.

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

Abstract: The invention relates to new compounds that mimic Glycosaminoglycans and are able to control interaction between Glycosaminoglycans with their effector molecules. The compounds of the invention are peptides and are able to prevent or reduce the binding of at least one effector molecule with at least one glycosaminoglycan. The compounds according to the invention can be used as drug, in particular for the stimulation of the neurogenesis and more generally to treat nervous system related pathologies.

Abstract: A distributed system including multiple processing nodes. The distributed system can perform certain acts. The acts can include receiving a first conflation event identifying a first node and a second node. The first node can be part of a first set. The first set can include a sole parent node stored at a first processing node of the multiple processing nodes. The second node can be part of a second set. The second set can include a sole parent node stored at a second processing node of the multiple processing nodes. The first and second sets can be disjoint sets. The first conflation event can be received at an event-driven stream application at one of the multiple processing nodes. The acts also can include conflating the first set and the second set into a conflated set. The conflated set can include the first and second nodes. The conflated set can include a sole parent node.

Abstract: An apparatus for treating a mat of mineral fibers moving along a plane and a run direction, by detection and elimination of localized defects, includes a first transport member, a second transport member positioned after the first transport member in the run direction and separated therefrom in the run direction by a treatment zone, a device for detecting localized defects in the mat of mineral fibers, upstream of the treatment zone in the run direction, and in the treatment zone, a device for eliminating defects suitable for eliminating, in-line, a defect detected by the detection device by eliminating the portion of mat containing it.

Abstract: Systems, methods and devices for distributed memory management comprising a network component configured for network communication with one or more memory resources that store data and one or more consumer devices that use data, the network component comprising a switching device in operative communication with a mapping resource, wherein the mapping resource is configured to associate mappings between data addresses associated with memory requests from a consumer device relating to a data object and information relating to a storage location in the one or more memory resources associated with the data from the data object, wherein each data address has contained therein identification information for identifying the data from the data object associated with that data address; and the switching device is configured to route memory requests based on the mappings.

Abstract: A turbomachine blade formed of a hollow airfoil having a leading edge and a trailing edge opposed to each other and connected by an intrados wall and an extrados wall each extending along a radial axis of the blade, between a blade root and a blade tip, and including a cooling circuit supplied with air and delivering air jets ensuring through multiple perforations of the cooling circuit an impingement cooling of the inner surface of the airfoil, the cooling circuit includes superimposed cooling channels over the height of the blade, each integrated into the inner surface of the airfoil while matching its contour, the multiple perforations being drilled in the cooling channels terminating in a purge cavity of the airfoil are able to ensure a purge of the air having impinged the inner surface of the airfoil after its passage through the perforations.

Abstract: The present invention relates to bicyclic pyridine, pyrazine, and pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to a method for the production of a soft cake having at least a molded face and at least a non-molded face, the molded face having at least one molded three-dimensional pattern, the method comprising the steps of: a) pouring a cake batter suitable for forming a soft cake into a pan, wherein the cake batter has a viscosity of between 500 and 1 Pa·s; b) baking said soft cake batter in said pan to form a soft cake; and c) removing the soft cake from the pan, wherein the pan has a molded inner surface for receiving the cake batter and which provides the three dimensional molding pattern of the soft cake, and wherein the molded inner surface of the pan has an arithmetical mean degree of roughness (Ra) of from 0.12 ?m to 0.

Abstract: The invention concerns compounds having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. Formula (Ia).

Abstract: A method for determining the focus of the visual attention of an individual from electroencephalographic signals. At least one visual stimulus to be displayed is generated from at least one graphical object, a visual stimulus being an animated graphical object obtained by applying to a graphical object a temporal succession of elementary transformations that is temporally parameterized by a corresponding modulation signal. From a plurality of electroencephalographic signals produced by the individual focusing his visual attention to one of the visual stimuli, a modulation signal is reconstructed. A visual stimulus corresponding to the modulation signal for which the degree of statistical dependence with the reconstructed modulation signal is higher than a first threshold is identified.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.