Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

Abstract: Disclosed are medical devices for use in delivering a medical solution into the body of a patient, including: an elongated main body defining a reservoir for containing a medical solution; longitudinal tip extending axially and distally from the main body, the longitudinal tip defining a fluid path extending axially through the longitudinal tip and in fluid communication with the reservoir; and a gripping portion formed on an outer surface of the longitudinal tip, wherein the main body and longitudinal tip are made of glass, the gripping portion including at least three ribs integrally formed with the longitudinal tip and extending around a longitudinal axis of the longitudinal tip, and the gripping portion has an average roughness of 0.5 ?m to 3 ?m.

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

Abstract: An apparatus for treating a mat of mineral fibers moving along a plane and a run direction, by detection and elimination of localized defects, includes a first transport member, a second transport member positioned after the first transport member in the run direction and separated therefrom in the run direction by a treatment zone, a device for detecting localized defects in the mat of mineral fibers, upstream of the treatment zone in the run direction, and in the treatment zone, a device for eliminating defects suitable for eliminating, in-line, a defect detected by the detection device by eliminating the portion of mat containing it.

Abstract: The present invention relates to azabenzimidazole derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Systems, methods and devices for distributed memory management comprising a network component configured for network communication with one or more memory resources that store data and one or more consumer devices that use data, the network component comprising a switching device in operative communication with a mapping resource, wherein the mapping resource is configured to associate mappings between data addresses associated with memory requests from a consumer device relating to a data object and information relating to a storage location in the one or more memory resources associated with the data from the data object, wherein each data address has contained therein identification information for identifying the data from the data object associated with that data address; and the switching device is configured to route memory requests based on the mappings.

Abstract: The present invention relates to bicyclic pyridine, pyrazine, and pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives of formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.

Abstract: The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: A measuring comb for temperature and/or pressure and/or chemical composition of the gases flowing at the outlet of a turbine engine flow path, in which the flow path extends around an axis of revolution of the flow path, is provided. The measuring comb includes: a comb body with an elongated shape, intended to face the outlet of the flow path, the comb body including at least one measuring opening arranged along an axis, the measuring opening being configured to tap gases flowing at the outlet of the flow path; and an adjusting system configured to adjust an angle between the axis of the at least one measuring opening and the axis of revolution, so as to allow orientation of the at least one measuring opening in the flow direction of the gases at the outlet of the flow path.

Abstract: A turbine engine having an annular combustion chamber formed by two coaxial annular shrouds, an inner shroud and an outer shroud relative to the axis of the turbine engine, which shrouds are arranged one inside the other and are connected together at their upstream ends by an annular chamber end wall that is fastened to an outer casing surrounding the outer annular shroud, the downstream ends of the inner and outer annular shrouds being connected to flanges fastened to an inner casing and to the outer casing, respectively. The upstream end of at least one of the inner and outer shrouds is centered by bearing radially against the annular chamber end wall and co-operates therewith in leaktight axial sliding.

Abstract: The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Systems, methods and devices for management of instances of virtual memory components for storing computer readable information for use by at least one first computing device, the system comprising at least one physical computing device, each physical computing device being communicatively coupled over a network and comprising: a physical memory component, a computing processor component, an operating system, a virtual machine monitor, and virtual memory storage appliances; at least one of the virtual memory storage appliances being configured to (a) accept memory instructions from the at least one first computing device, (b) instantiate instances of at least one virtual memory component, (c) allocate memory resources from at least one physical memory component for use by any one of the least one virtual memory components, optionally according to a pre-defined policy; and (d) implement memory instructions on the at least one physical memory component.

Abstract: A method for diagnosing the state of wear of an electrical switching unit including an electrical unit monitoring phase. The monitoring phase uses learning data loaded previously and representative of the type of electrical unit, and initialization data corresponding to the unit to be monitored and stored in an initialization phase. The monitoring phase includes the measurement and the acquisition of a measurement curve on opening the electrical unit, the determination of the value of local descriptors of the measurement curve as a function of values of the measurement curve, of initialization data and of learning data, the determination of the positioning of local descriptor values, the determination of an overall state class as a function of the positioning values. The device and the electrical unit implement the method.

Abstract: An injection system for a turbine engine combustion chamber is provided. The injection system includes a first annular deflector surrounded by the bowl of the injection system and extending in the downstream direction from the downstream transverse surface that delimits the downstream side of the swirler. The first deflector has a free downstream end offset in the upstream direction from a downstream end of the bowl, so as to guide an air film output from the first orifices formed through the bowl. The internal radius of the cross section of the first annular deflector increases from the downstream transverse surface as far as the downstream end of the first annular deflector.

Abstract: An annular combustion chamber for a turbine engine is provided. The chamber includes an annular row of fuel injectors including heads engaged in fuel injection systems mounted in openings in the chamber end wall. Each injector head includes at least one fuel-passing helical channel for causing fuel to rotate about the longitudinal axis of the head. Each injection system includes at least one swirler including air-passing channels of sections with axes that are inclined relative to the plurality axis of the swirler at an angle that is substantially equal to a helix angle of the helical channel, to within ±10°, and are oriented in a same direction as the channel about the longitudinal axis of the swirler.

Abstract: In one example, a proxy server acts as a gateway to a website and modifies the traffic between a web browser on a user device and the website server, as necessary to request protection by providing step-up authentication and/or transaction verification. The proxy server blocks transactions when protection is required but has not occurred (either because the authentication was not proper or due to the detection of another problem). Associated methods and systems are also provided.

Abstract: The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.