Abstract: In one example, a proxy server acts as a gateway to a website and modifies the traffic between a web browser on a user device and the website server, as necessary to request protection by providing step-up authentication and/or transaction verification. The proxy server blocks transactions when protection is required but has not occurred (either because the authentication was not proper or due to the detection of another problem). Associated methods and systems are also provided.

Abstract: The present invention relates to heterocyclyl linked imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present invention relates to a method for the production of a soft cake having at least a molded face and at least a non-molded face, the molded face having at least one molded three-dimensional pattern, the method comprising the steps of: a) pouring a cake batter suitable for forming a soft cake into a pan, wherein the cake batter has a viscosity of between 500 and 1 Pa·s; b) baking said soft cake batter in said pan to form a soft cake; and c) removing the soft cake from the pan, wherein the pan has a molded inner surface for receiving the cake batter and which provides the three dimensional molding pattern of the soft cake, and wherein the molded inner surface of the pan has an arithmetical mean degree of roughness (Ra) of from 0.12 ?m to 0.

Abstract: The present invention relates to substituted imidazopyridazine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as pI3K? inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The impact shield (9, 10) carries a plurality of armor bodies (16) of a strongly wear resisting material. The armor bodies (16) are fixed horizontally in succession on a front side of the impact shield by a fixing element making it possible to detach them from the impact shield (9, 10) for their replacement. The impact shield (9, 10) is composed of a fixed part (21) connected to the frame (2), and a removable part (22) carrying the armor bodies (16) and making it possible to remove simultaneously all the armor bodies, fixed on the same, out of the grinding chamber (3). At least one such impact shield (9, 10) is arranged in a grinding chamber (3) of an impact grinding mill including a frame (2) further including a horizontal-axis rotor (6) provided with impactors (7) arranged regularly around its periphery.

Abstract: Compounds of formula I and a process for manufacturing the compounds. A method of using the compounds for the detection of calcium ions and a method of detecting intracellular calcium are also described.

Abstract: A measuring comb for temperature and/or pressure and/or chemical composition of the gases flowing at the outlet of a turbine engine flow path, in which the flow path extends around an axis of revolution of the flow path, is provided. The measuring comb includes: a comb body with an elongated shape, intended to face the outlet of the flow path, the comb body including at least one measuring opening arranged along an axis, the measuring opening being configured to tap gases flowing at the outlet of the flow path; and an adjusting system configured to adjust an angle between the axis of the at least one measuring opening and the axis of revolution, so as to allow orientation of the at least one measuring opening in the flow direction of the gases at the outlet of the flow path.

Abstract: The present invention relates to substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives of formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as ROS1 inhibitors. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: An annular combustion chamber including inner and outer walls forming surfaces of revolution that are connected together upstream by an annular chamber end wall having injection systems passing therethrough. Each injection system includes at least one swirler for producing a rotating stream of air downstream from a fuel injector, and a frustoconical bowl downstream from the swirler and formed with an annular row of air injection orifices, the outer wall having an annular row of primary dilution orifices. The orifices of the bowls are distributed and dimensioned such that sheets of air/fuel mixture present a local enlargement circumferentially intersecting an adjacent sheet of fuel upstream from the primary dilution orifices.

Abstract: A sectorized nozzle for a turbine engine turbine including an inner sectorized annular platform and an outer sectorized annular platform connected together by radial airfoils, at least one of the platforms including a plurality of orifices for passing air in a neighborhood of its upstream end, the orifices being distributed over the circumference of the platform and opening out at their ends remote from the airfoils into a circumferential annular cavity of the sector of the platform, which cavity is closed by a metal sheet fastened to the platform sector and pierced by orifices for feeding cooling air.

Abstract: An annular combustion chamber of a turbine engine, the chamber including inner and outer coaxial walls forming two surfaces of revolution, which are connected together upstream by an annular chamber end wall including injection systems passing therethrough, each including an injector and at least one swirler for producing a rotating air stream that mixes downstream with fuel from the injector, and at least one ignition spark plug mounted in an orifice of the outer wall downstream from the injection systems. The spark plug is situated circumferentially between two adjacent injection systems that are configured to produce two air/fuel mixture sheets rotating in opposite directions.

Abstract: Compounds of formula I and a process for manufacturing the compounds. A method of using the compounds for the detection of calcium ions and a method of detecting intracellular calcium are also described.

Abstract: Systems, methods and devices for distributed memory management comprising a network component configured for network communication with one or more memory resources that store data and one or more consumer devices that use data, the network component comprising a switching device in operative communication with a mapping resource, wherein the mapping resource is configured to associate mappings between data addresses associated with memory requests from a consumer device relating to a data object and information relating to a storage location in the one or more memory resources associated with the data from the data object, wherein each data address has contained therein identification information for identifying the data from the data object associated with that data address; and the switching device is configured to route memory requests based on the mappings.

Abstract: The present invention discloses compositions of novel DYRK1A protein inhibitors based on a 3,5-diarylazaindole motif and their preparation and use as medications in the treatment of cognitive disorders associated with dysfunction of DYRK1A protein, with Down's syndrome and with Alzheimer's disease.

Abstract: A method and structure negating thermal inertia of a solid portion, such as shielding, which influences mechanical behavior of parts of an engine structure, by reducing forces transmitted to the engine structure during an event in which a turbine blade ruptures, while preserving mechanical strength and vibratory positioning. The structure includes a flexible fastener for a shield, enabling producing a fusible section. An assembly for mounting a shielding onto a casing of the engine structure of a turbine includes connection lugs and points for attachment to the casing and shielding. The attachment points are sufficiently spaced apart in accordance with curvature of the shielding and casing so connection between the lugs and the shielding or casing, and connection of the attachment points, are substantially tangential. The lugs are sized so the connection has sufficient flexibility to control vibratory positioning thereof and ensure sufficient mechanical strength under thermo-mechanical loads.

Abstract: Systems, methods and devices for distributed memory management comprising a network component configured for network communication with one or more memory resources that store data and one or more consumer devices that use data, the network component comprising a switching device in operative communication with a mapping resource, wherein the mapping resource is configured to associate mappings between data addresses associated with memory requests from a consumer device relating to a data object and information relating to a storage location in the one or more memory resources associated with the data from the data object, wherein each data address has contained therein identification information for identifying the data from the data object associated with that data address; and the switching device is configured to route memory requests based on the mappings.

Abstract: A turbomachine combustion chamber shell ring in which dilution holes in the turbomachine combustion chamber shell ring are covered with inserts defining chambers around same on an inner face of the shell ring. Ventilation holes, through the insert, induce ventilation of portions of the shell ring surrounding the dilution holes, cool the portions, and prevent crack formation.

Abstract: A device for the dry handling of nuclear fuel assemblies is provided. The device includes a transfer basket which can be connected to a lifter and which includes a gripper for gripping the fuel assembly to be transferred, the gripper being supported by a lift built into the basket; and an indexing table which can be placed on a cask and which comprises a positioner for positioning the basket over a slot in the cask.

Abstract: A turbine engine having an annular combustion chamber formed by two coaxial annular shrouds, an inner shroud and an outer shroud relative to the axis of the turbine engine, which shrouds are arranged one inside the other and are connected together at their upstream ends by an annular chamber end wall that is fastened to an outer casing surrounding the outer annular shroud, the downstream ends of the inner and outer annular shrouds being connected to flanges fastened to an inner casing and to the outer casing, respectively. The upstream end of at least one of the inner and outer shrouds is centered by bearing radially against the annular chamber end wall and co-operates therewith in leaktight axial sliding.

Abstract: In known types of injection systems for a turbine engine combustion chamber, the secondary fuel flow strikes the venturi before entering into the combustor. A new injection system is disclosed to overcome this problem, comprising a first annular deflector surrounded by the bowl of the injection system and extending in the downstream direction from the downstream transverse surface that delimits the downstream side of the swirler. This first deflector has a free downstream end offset in the upstream direction from a downstream end of the bowl, so as to guide an air film output from the first orifices formed through the bowl. The internal radius ? of the cross section of the first annular deflector increases from the downstream transverse surface as far as the downstream end of the first annular deflector.