Patents by Inventor Jeffery Marks

Jeffery Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160020079
    Abstract: A sample plate 1 for an ion source is disclosed comprising a plurality of ionisation regions, each ionisation region comprising a first electrode 4 and a second separate electrode 4 separated by an insulator 4a.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 21, 2016
    Inventor: Jeffery Mark Brown
  • Publication number: 20160013039
    Abstract: A Time of Flight mass analyser is disclosed comprising one or more acceleration electrodes and a first device arranged and adapted to apply a DC voltage pulse to the one or more acceleration electrodes. The DC voltage pulse causes ions to be accelerated into a time of flight or drift region and the DC voltage pulse is applied, in use, to the one or more acceleration electrodes between a time T1 and a time T2. A second device is arranged and adapted to apply a single phase oscillating voltage to the one or more acceleration electrodes, wherein the single phase oscillating voltage undergoes multiple oscillations between the time T1 and the time T2. The application of the DC voltage pulse and the single phase oscillating voltage to the one or more acceleration electrodes establishes an homogeneous electric field having a net force towards the time of flight or drift region.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Publication number: 20150380231
    Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Publication number: 20150380232
    Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region. The collision or reaction device further comprises a device arranged and adapted to determine the time when the second ions and/or ions derived from the second ions are substantially ejected from the first device.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 9190256
    Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ?300 mm. The laser beam is directed onto the target substrate at an angle ? with respect to the perpendicular to the target substrate, wherein ??3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: November 17, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Paul Murray, Daniel James Kenny
  • Publication number: 20150294846
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Application
    Filed: June 26, 2015
    Publication date: October 15, 2015
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Publication number: 20150270114
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Patent number: 9136098
    Abstract: A pulsed ion source is disclosed wherein the ion source is energized one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: September 15, 2015
    Assignee: Micromass UK Limited
    Inventors: Jason Lee Wildgoose, Steven Derek Pringle, Kevil Giles, Jeffery Mark Brown, Paul Murray, Daniel James Kenny
  • Patent number: 9129783
    Abstract: A method of mass spectrometry is disclosed comprising providing a mixture of different analyte ions and supplying electrons or reagent ions to said mixture so as to transfer charge to the analyte ions. The transfer of charge causes at least some of the analyte ions to dissociate and others of the analyte ions not to dissociate, but to form intermediate ions of altered charge state. These intermediate ions are then isolated from other ions and excited so as to dissociate into daughter ions. The intermediate ions and their daughter ions are analyzed and associated with each other so that the intermediate can be identified from their daughter ions. The analyte ions can then be identified from the intermediate ions, since they differ only in charge state. The disclosed method enables analyte ions to be associated with their fragment ions, and therefore identified, without having to isolate individual analyte ions prior to their interactions with the electrons or reagent ions.
    Type: Grant
    Filed: April 5, 2013
    Date of Patent: September 8, 2015
    Assignees: Micromass UK Limited, The University of British Columbia
    Inventors: Jeffery Mark Brown, Damon Robb
  • Patent number: 9123523
    Abstract: A mass spectrometer is disclosed comprising an RF ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the RF ion guide or ion trap. The mass spectrometer further comprises a photo-ionization device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the RF ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionization device to photo-ionize and/or photo-excite the reagent gas to form reagent ions, excited species or radical species. The reagent ions, excited species or radical species interact with at least some of the neutral molecules located within the RF ion guide or ion trap to form analyte ions.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: September 1, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jeffery Mark Brown
  • Patent number: 9117644
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: August 25, 2015
    Assignee: Micromass UK Limited
    Inventors: Martin Raymond Green, Jason Lee Wildgoose, Jeffery Mark Brown
  • Patent number: 9111740
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimize the fragmentation and charge reduction process.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: August 18, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 9080936
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode (14) which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: July 14, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Patent number: 9082596
    Abstract: A method of mass spectrometry is disclosed comprising passing ions through an ion mobility spectrometer and acquiring first ion mobility drift time data. A calibration function is applied to the first ion mobility drift time data to determine a physico-chemical property (e.g. CCS) of the ions. Second ion mobility drift time data is then acquired and the calibration function is applied to the second ion mobility drift time data to determine the physico-chemical property of one or more known or reference ions. The calibration function is then adjusted.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: July 14, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Kevin Giles
  • Patent number: 9070539
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: June 30, 2015
    Assignee: Micromass UK Limited
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Patent number: 9070540
    Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: June 30, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 9053918
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: June 9, 2015
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Publication number: 20150155149
    Abstract: A mass spectrometer is disclosed comprising a cooling cell 4 for cooling ions so as to reduce their kinetic energy. The cooling cell 4 comprises: a chamber for receiving the ions or for generating the ions therein, wherein said chamber is formed from walls defining a substantially enclosed region; and a cooling jacket 16 surrounding said chamber, wherein said cooling jacket 16 is arranged and configured to contain a cooling fluid and so as to remove heat from one or more walls of the chamber. The mass spectrometer further comprises a mass analyser 6 for receiving ions from the cooling cell 4 after they have been cooled. The present invention reduced the kinetic energy of the ions prior to mass analysis and hence improves the resolution of the mass analyser 6. The mass analyser is preferably a time of flight mass analyser.
    Type: Application
    Filed: May 8, 2013
    Publication date: June 4, 2015
    Applicant: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Jason Lee Wildgoose
  • Publication number: 20150144780
    Abstract: A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analysed and a second mode in which the parent ions are subjected to Electron Capture Dissociation (“ECD”) at atmospheric pressure so as to produce fragment ions which are then mass analysed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.
    Type: Application
    Filed: May 16, 2013
    Publication date: May 28, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Publication number: 20150097114
    Abstract: A mass spectrometer is disclosed comprising an RF ion guide or ion trap and a device arranged and adapted to supply a reagent gas within the RF ion guide or ion trap. The mass spectrometer further comprises a photo-ionisation device and a control system arranged and adapted: (i) to cause first ions to fragment or dissociate within the RF ion guide or ion trap to form second ions and neutral molecules; and (ii) to cause the photo-ionisation device to photo-ionise and/or photo-excite the reagent gas to form reagent ions, excited species or radical species. The reagent ions, excited species or radical species interact with at least some of the neutral molecules located within the RF ion guide or ion trap to form analyte ions.
    Type: Application
    Filed: May 16, 2013
    Publication date: April 9, 2015
    Inventors: Martin Raymond Green, Jeffery Mark Brown