Patents by Inventor Jeffery Marks

Jeffery Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140051181
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Application
    Filed: October 25, 2013
    Publication date: February 20, 2014
    Applicant: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Publication number: 20140042314
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
    Type: Application
    Filed: October 17, 2013
    Publication date: February 13, 2014
    Applicant: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 8624179
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: January 7, 2014
    Assignee: Micromass UK Limited
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Patent number: 8563921
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: October 22, 2013
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Publication number: 20130256524
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
    Type: Application
    Filed: June 7, 2011
    Publication date: October 3, 2013
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Publication number: 20130206974
    Abstract: A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.
    Type: Application
    Filed: February 14, 2011
    Publication date: August 15, 2013
    Applicant: MICROMASS UK LIMITED
    Inventor: Jeffery Mark Brown
  • Patent number: 8507849
    Abstract: A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyzer. The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: August 13, 2013
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown
  • Publication number: 20130122599
    Abstract: A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.
    Type: Application
    Filed: January 31, 2011
    Publication date: May 16, 2013
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Iain Campuzano, Darryl W. Brousmiche, Craig Dorschel, Jonathan Paul Williams, Steven Derek Pringle, Keith Richardson
  • Patent number: 8410437
    Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: April 2, 2013
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 8362424
    Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
    Type: Grant
    Filed: November 24, 2008
    Date of Patent: January 29, 2013
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 8283626
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: October 9, 2012
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Publication number: 20120208289
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
    Type: Application
    Filed: April 23, 2012
    Publication date: August 16, 2012
    Applicant: MICROMASS UK LIMITED
    Inventors: Martin R. Green, Jason Lee Wildgoose, Jeffery Mark Brown
  • Patent number: 8164052
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: April 24, 2012
    Assignee: Micromass UK Limited
    Inventors: Martin R. Green, Jason Lee Wildgoose, Jeffery Mark Brown
  • Patent number: 8063358
    Abstract: A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: November 22, 2011
    Assignee: Micromass UK Ltd.
    Inventors: Robert Harold Bateman, Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
  • Publication number: 20110189788
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Application
    Filed: July 27, 2009
    Publication date: August 4, 2011
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Publication number: 20110114835
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Application
    Filed: June 5, 2009
    Publication date: May 19, 2011
    Applicant: MICROMASS UK LIMITED
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Publication number: 20110062323
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
    Type: Application
    Filed: April 3, 2009
    Publication date: March 17, 2011
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Publication number: 20110024618
    Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.
    Type: Application
    Filed: November 24, 2008
    Publication date: February 3, 2011
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Patent number: 7863557
    Abstract: A multi-turn Time of Plight mass analyzer is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple loops or circuits of the mass analyzer before being detected and mass analyzed enabling a high resolution mass analyzer to be provided. According to another embodiment the mass analyzer may have an open-loop geometry wherein the first electric sector is elongated and further electric sectors are arranged in a staggered manner along the length of the first electric sector. The first and second electric sectors (5,8) may be sub-divided into a plurality of electric sector segments.
    Type: Grant
    Filed: March 14, 2007
    Date of Patent: January 4, 2011
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown
  • Patent number: 7851744
    Abstract: A Matrix Assisted Laser Desorption Ionization ion source or ion imaging device is disclosed comprising a laser (1) and a zoom lens (3, 4, 5). The zoom lens (3, 4, 5) is arranged to be able to vary the magnification of a laser beam which is directed onto a target region, sample surface or target plate (13) of the ion source or ion imaging device.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: December 14, 2010
    Assignee: Micromass UK LImited
    Inventors: Jeffery Mark Brown, Daniel James Kenny