Patents by Inventor Jeffery Marks
Jeffery Marks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140051181Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.Type: ApplicationFiled: October 25, 2013Publication date: February 20, 2014Applicant: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
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Publication number: 20140042314Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.Type: ApplicationFiled: October 17, 2013Publication date: February 13, 2014Applicant: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green
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Patent number: 8624179Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.Type: GrantFiled: June 5, 2009Date of Patent: January 7, 2014Assignee: Micromass UK LimitedInventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
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Patent number: 8563921Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.Type: GrantFiled: October 5, 2012Date of Patent: October 22, 2013Assignee: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green
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Publication number: 20130256524Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.Type: ApplicationFiled: June 7, 2011Publication date: October 3, 2013Applicant: MICROMASS UK LIMITEDInventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
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Publication number: 20130206974Abstract: A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.Type: ApplicationFiled: February 14, 2011Publication date: August 15, 2013Applicant: MICROMASS UK LIMITEDInventor: Jeffery Mark Brown
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Patent number: 8507849Abstract: A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyzer. The mass spectrometer is operated at a first instrument setting wherein specific parent ions are selected by a mass filter and are accelerated to a first axial energy. The fragment ions are then orthogonally accelerated after a first delay time and first mass spectral data is obtained. The mass spectrometer is then operated at a second instrument setting wherein the axial energy of the parent ions is increased and the resulting fragment ions are orthogonally accelerated after a reduced delay time. Second mass spectral data is then obtained. The first and second mass spectral data are then combined to provided a final composite mass spectrum.Type: GrantFiled: December 19, 2005Date of Patent: August 13, 2013Assignee: Micromass UK LimitedInventor: Jeffery Mark Brown
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Publication number: 20130122599Abstract: A mass spectrometry electron transfer dissociation reagent comprising an unsaturated compound having a Frank Condon factor between 0.1 and 1.0 and an electron affinity having a positive value between 0.1 to 150 kJ/mol.Type: ApplicationFiled: January 31, 2011Publication date: May 16, 2013Applicant: MICROMASS UK LIMITEDInventors: Jeffery Mark Brown, Iain Campuzano, Darryl W. Brousmiche, Craig Dorschel, Jonathan Paul Williams, Steven Derek Pringle, Keith Richardson
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Patent number: 8410437Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).Type: GrantFiled: November 24, 2008Date of Patent: April 2, 2013Assignee: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green
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Patent number: 8362424Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes forming an ion guide. A transient DC voltage wave is applied to the electrodes in order to load reagent anions into the ion guide. Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.Type: GrantFiled: November 24, 2008Date of Patent: January 29, 2013Assignee: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green
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Patent number: 8283626Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.Type: GrantFiled: April 3, 2009Date of Patent: October 9, 2012Assignee: Micromass UK LimitedInventors: Jeffery Mark Brown, Martin Raymond Green
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Publication number: 20120208289Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.Type: ApplicationFiled: April 23, 2012Publication date: August 16, 2012Applicant: MICROMASS UK LIMITEDInventors: Martin R. Green, Jason Lee Wildgoose, Jeffery Mark Brown
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Patent number: 8164052Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell (1). Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell (1). The cell comprises a plurality of ring electrodes (1) which form a spherical trapping volume. Ions experience negligible RF heating over the majority, of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell (1) having an enhanced sensitivity is thereby provided. Fragment ions created within the cell (1) may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.Type: GrantFiled: March 26, 2008Date of Patent: April 24, 2012Assignee: Micromass UK LimitedInventors: Martin R. Green, Jason Lee Wildgoose, Jeffery Mark Brown
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Patent number: 8063358Abstract: A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined.Type: GrantFiled: June 1, 2006Date of Patent: November 22, 2011Assignee: Micromass UK Ltd.Inventors: Robert Harold Bateman, Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
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Publication number: 20110189788Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode (14) located within an isolation valve (15) which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode (14) which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.Type: ApplicationFiled: July 27, 2009Publication date: August 4, 2011Applicant: MICROMASS UK LIMITEDInventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
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Publication number: 20110114835Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell 35 by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.Type: ApplicationFiled: June 5, 2009Publication date: May 19, 2011Applicant: MICROMASS UK LIMITEDInventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
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Publication number: 20110062323Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.Type: ApplicationFiled: April 3, 2009Publication date: March 17, 2011Applicant: MICROMASS UK LIMITEDInventors: Jeffery Mark Brown, Martin Raymond Green
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Publication number: 20110024618Abstract: An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave.Type: ApplicationFiled: November 24, 2008Publication date: February 3, 2011Applicant: MICROMASS UK LIMITEDInventors: Jeffery Mark Brown, Martin Raymond Green
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Patent number: 7863557Abstract: A multi-turn Time of Plight mass analyzer is disclosed comprising a first electric sector (5) and a second electric sector (8). The second electric sector (8) is arranged orthogonal to the first electric sector (5). Ions may make multiple loops or circuits of the mass analyzer before being detected and mass analyzed enabling a high resolution mass analyzer to be provided. According to another embodiment the mass analyzer may have an open-loop geometry wherein the first electric sector is elongated and further electric sectors are arranged in a staggered manner along the length of the first electric sector. The first and second electric sectors (5,8) may be sub-divided into a plurality of electric sector segments.Type: GrantFiled: March 14, 2007Date of Patent: January 4, 2011Assignee: Micromass UK LimitedInventor: Jeffery Mark Brown
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Patent number: 7851744Abstract: A Matrix Assisted Laser Desorption Ionization ion source or ion imaging device is disclosed comprising a laser (1) and a zoom lens (3, 4, 5). The zoom lens (3, 4, 5) is arranged to be able to vary the magnification of a laser beam which is directed onto a target region, sample surface or target plate (13) of the ion source or ion imaging device.Type: GrantFiled: December 23, 2005Date of Patent: December 14, 2010Assignee: Micromass UK LImitedInventors: Jeffery Mark Brown, Daniel James Kenny