Abstract: The present invention provides methods of preparing 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidin-4(3H)-one, and 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidin-4(3H)-one monohydrate, as well as new intermediate compounds.

Abstract: A method and apparatus for evaluating emergence of an ulcer each uses at least one temperature detection modality to form a first thermogram and a second thermogram of the sole of at least one foot. Each thermogram forms a substantially continuous set of two-dimensional temperature values across the sole of the (at least one) foot. The thermograms have features; namely, the first thermogram has first features and the second thermogram has second features. The method and apparatus thus control a device to apply at least one transformation to the first and second thermograms to align the first features with corresponding second features, and determine, at any thermogram location, if at least one of the thermograms presents one of a plurality of patterns indicative of inflammation. Finally, the method and apparatus each produce output information indicating the result of the determination of whether the thermograms present one of the plurality of patterns.

Abstract: An apparatus (200) and method for preparing a cylindrical object having a protective surface coating, such as a necked can (100), for decorating thereon using a printing technique. According to the method, a primer is applied onto the surface coating, and the primer is then dried to form a surface for decorating the object. The apparatus comprises a priming station (260) for applying a primer onto said surface coating, and a drying station (270) for drying the primer.

Abstract: A system and method for determining the locations and types of objects in a plurality of videos. The method comprises pairing each video with one or more sentences describing the activity or activities in which those objects participate in the associated video, wherein no use is made of a pretrained object detector. The object locations are specified as rectangles, the object types are specified as nouns, and sentences describe the relative positions and motions of the objects in the videos referred to by the nouns in the sentences. The relative positions and motions of the objects in the video are described by a conjunction of predicates constructed to represent the activity described by the sentences associated with the videos.

Abstract: The present disclosure relates to methods of administering Compound I for treating fibrotic disorders, inflammatory disorders or autoimmune disorders.

Abstract: The present disclosure provides an apparatus for handling objects. The apparatus comprises a carrying device (104) that is configured to move along a track (102). A handling device (224) is adapted to hold an object (108) and is mounted to the carrying device (104) such that it is rotatable with respect to the carrying device about a handling axis (226). A drive device (310) is disposed at a position along the track (102) and configured to produce a torque around a drive axis. The carrying device (104) can be moved along the track (102) in a direction perpendicular to the drive axis into and out of a drive position. In the drive position, the handling axis (226) of the handling device (224) is in substantial alignment with the drive axis of the drive device (310) whereupon the drive device induces a torque in the handling device (224) causing the handling device to rotate, thereby causing the object (108) held by the handling device to rotate.

Abstract: Systems and methods to assess formation data are disclosed. The method includes partitioning a formation containing a plurality of rock types into a plurality of sections. For a section of the plurality of sections, the method also includes determining, for each rock type of the plurality of rock types, a probability that the rock type is present in the section. The method further includes assigning a value to the section of the plurality of sections based on a probability that the section contains one or more rock types of the plurality of rock types. The method further includes analyzing the formation based on the value associated with the section.

Abstract: A printing system for printing on an outer surface of a tubular object is provided. The printing system comprises at least one printing station for printing on the outer surface of the tubular object (100); and at least one holding device for holding the tubular object during a printing process. The holding device comprises: a substantially annular gripper ring (200) adapted to be partially inserted into a tubular object. The gripper ring comprises a radially compressible portion (201) configured to securely engage with an inner surface of the tubular object. The radially compressible portion exerts a radially outward mechanical restoring force when compressed.

Abstract: A method and apparatus for evaluating foot inflammation each uses at least one temperature detection modality to form a first thermogram and a second thermogram of the sole of at least one foot. Each thermogram forms a substantially continuous set of two-dimensional temperature values across the sole of the (at least one) foot. The thermograms have features; namely, the first thermogram has first features and the second thermogram has second features. The method and apparatus thus control a device to apply at least one transformation to the first and second thermograms to align the first features with corresponding second features, and determine, at any thermogram location, if at least one of the thermograms presents one of a plurality of patterns indicative of inflammation. Finally, the method and apparatus each produce output information indicating the result of the determination of whether the thermograms present one of the plurality of patterns.

Abstract: A system for transmitting rotational motion between a driving element and a driven element comprises a driving element that is coupled to a torque input that causes the driving element to rotate about a drive axis. The driving element comprises a first magnetic element. A driven element is configured to rotate about a driven axis. The driven element comprises a second magnetic element. Both the first magnetic element and second magnetic element are susceptible to a magnetic field, and at least one of the first and second magnetic element produces a magnetic field. A magnetic interaction between the first magnetic element and the second magnetic element couples the rotational motion of the driving element and the rotational motion of the driven element. The driving and driven elements are coupled at a predetermined rotational orientation with respect to each other.

Abstract: Vacuum-integrated photoresist-less methods and apparatuses for forming metal hardmasks can provide sub-30 nm patterning resolution. A metal-containing (e.g., metal salt or organometallic compound) film that is sensitive to a patterning agent is deposited on a semiconductor substrate. The metal-containing film is then patterned directly (i.e., without the use of a photoresist) by exposure to the patterning agent in a vacuum ambient to form the metal mask. For example, the metal-containing film is photosensitive and the patterning is conducted using sub-30 nm wavelength optical lithography, such as EUV lithography.

Abstract: Aspects and features of this disclosure provide a high-availability storage platform employing multiple redundant sites. Replication to multiple sites can begin upon receiving content and can be completed quickly, in part through the use of a small and efficient file that can be sent to storage sites. The file enables each storage site to efficiently build appropriate entries in a reference registry for storing and indexing the content. In some examples, a registration request including the content is received and the content is stored in an instance of the centralized storage system at an initial storage site. The aforementioned file is transmitted to additional storage sites to cause the content to be stored in additional instances of the centralized storage system. The file can also be accessed at the additional storage sites to update instances of the reference registry.

Abstract: The present disclosure relates to methods of administering Compound I for treating fibrotic disorders, inflammatory disorders or autoimmune disorders.

Abstract: Vacuum-integrated photoresist-less methods and apparatuses for forming metal hardmasks can provide sub-30 nm patterning resolution. A metal-containing (e.g., metal salt or organometallic compound) film that is sensitive to a patterning agent is deposited on a semiconductor substrate. The metal-containing film is then patterned directly (i.e., without the use of a photoresist) by exposure to the patterning agent in a vacuum ambient to form the metal mask. For example, the metal-containing film is photosensitive and the patterning is conducted using sub-30 nm wavelength optical lithography, such as EUV lithography.

Abstract: Techniques for inserting advertising content into digital content are disclosed. The system may determine a compatibility between advertising content and digital content, determine candidate advertising content and candidate digital content using the determined compatibility, determine that the candidate digital content includes an advertising zone specifying an area where advertising content may be inserted, determine that an advertising slot of the candidate advertising content matches the advertising zone, and select digital content from the candidate digital content. The system may further select advertising content from the candidate advertising content, and combine selected digital content and selected advertising content by inserting the selected advertising content into the advertising zone.

Abstract: A method of monitoring a patient's foot forms a thermogram of the sole of at least one foot of the patient, and determines whether the thermogram presents at least one of a plurality of prescribed patterns. The method also compares the thermogram against a prior thermogram of the same foot, and produces output information indicating the emergence of an ulcer on a given portion on the at least one foot as a function of 1) whether the thermogram is determined to present the at least one pattern, and 2) the comparison with the prior thermogram, which shows non-ulcerated tissue at the given location.

Abstract: A delay interpolator includes pull-up devices, wherein each of the pull-up devices is coupled between a supply rail and a node, and pull-down devices, wherein each of the pull-down devices is coupled between the node and a ground. The delay interpolator also includes a first control circuit coupled to the pull-up devices, wherein the first control circuit has a first input configured to receive a first signal, a second input configured to receive a second signal that is delayed with respect to the first signal, and a control input configured to receive a first delay code; and. The delay interpolator further includes a second control circuit coupled to the pull-down devices, wherein the second control circuit has a first input configured to receive the first signal, a second input configured to receive the second signal, and a control input configured to receive a second delay code.

Abstract: The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.

Abstract: Captured samples of a physical structure or other scene are mapped to a predetermined multi-dimensional coordinate space, and spatially-adjacent samples are organized into array cells representing subspaces thereof. Each cell is classified according to predetermined target-identifying criteria for the samples of the cell. A cluster of spatially-contiguous cells of common classification, peripherally bounded by cells of different classification, is constructed, and a boundary demarcation is defined from the peripheral contour of the cluster. The boundary demarcation is overlaid upon a visual display of the physical scene, thereby visually demarcating the boundaries of a detected target of interest.

Abstract: A system includes delay locked loop (DLL) including a phase detector having a first input coupled to an input of the DLL, and a first delay circuit and a second delay circuit coupled in series between the input of the DLL and a second input of the phase detector. The DLL further includes a first control circuit, wherein an input of the first control circuit is coupled to an output of the phase detector, a first output of the first control circuit is coupled to a control input of the first delay circuit, and a second output of the first control circuit is coupled to a control input of the second delay circuit. The system also includes a second control circuit having an input coupled to the first control circuit, and a slave delay circuit having a control input coupled to an output of the second control circuit.