Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.

Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: Provided herein are an optical test platform and corresponding method of manufacturing the same. The test platform may include a shell defining a cavity for receiving a sample tube, a first aperture, and a second aperture. The first aperture and the second aperture of the shell may each be configured to optically couple the cavity with an exterior of the shell. The test platform may further include a first window and a second window embedded in the shell. The first window may seal a first aperture and the second window may seal a second aperture. The first window and second window may each permit the optical coupling of the cavity with the exterior of the shell. The first window and the second window may be optically coupled via the cavity, and the shell may prohibit optical coupling between the first window and the second window through the shell.

Abstract: A method for performing an electrosurgical procedure using an electrosurgical instrument including an end effector is disclosed. The method comprises applying a bipolar energy to a target tissue grasped by the end effector in a tissue-feathering segment, applying an energy blend of the bipolar energy and a monopolar energy to the target tissue in a tissue-warming segment and a tissue-sealing segment following the tissue-warming segment, and discontinuing the bipolar energy but continuing to apply the monopolar energy to the target tissue in a tissue-cutting segment following the tissue-sealing segment.

Abstract: A method optimizes a training of a machine learning system. A conflict detection system discovers a conflict between a first training data and a second training data for a machine learning system, where the first training data and the second training data are ground truths that describe a same type of entity, and where the first training data and the second training data have different labels. In response to discovering the conflict between the first training data and the second training data for the machine learning system, an oracle adjusts the different labels of the first training data and the second training data. The machine learning system is then trained using the first training data and the second training data with the adjusted labels.

Abstract: An insulated shipping container is provided for maintaining a substantially uniform internal temperature. The base, walls and lid of an outer box define an enclosure. An insulating body and an insulating cover are located within the enclosure and define an insulated cavity. A chamber having a plurality of chamber sides is configured to hold one or more payloads at the substantially uniform internal temperature. A temperature control material distribution structure is located within the insulated cavity for constraining motion of temperature control material units. The temperature control material distribution structure comprises at least one partitioned tray or trough. The at least one partitioned tray comprises a tray bottom; and a plurality of partition walls extending away from the tray bottom and defining a plurality of partition compartments.

Abstract: A computer system displays a first view of a user interface of a first application with a first size at a first position corresponding to a location of at least a portion of a palm that is currently facing a viewpoint corresponding to a view of a three-dimensional environment provided via a display generation component. While displaying the first view, the computer system detects a first input that corresponds to a request to transfer display of the first application from the palm to a first surface that is within a first proximity of the viewpoint. In response to detecting the first input, the computer system displays a second view of the user interface of the first application with a second size and an orientation that corresponds to the first surface at a second position defined by the first surface.

Abstract: Embodiments of the present disclosure comprise occlusion and drug delivery devices and methods. One aspect of the disclosure comprises a drug delivery device comprising an inner expansion member and an outer drug delivery component. Another aspect of the disclosure comprises bioabsorbable, lumen-occluding implants.

Abstract: A system for generating a series of reducing intensity laser pulses from an ultrafast pulsed laser source. The reducing intensity series of pulses is equally temporally spaced between pulses from the laser source. The repeating series of reducing intensity laser pulses is fed to a microscope for imaging. The microscope is capable of detecting the fluorescence from a sample generated by each pulse in the series. The data is processed using knowledge of the pulse intensity, location on the test sample, and amount of fluorescence measured to create an increased dynamic range of the image relative to what can be obtained in a normal two-photon imaging system.

Abstract: A method is disclosed and includes authenticating a first stage boot loader and authenticating a second stage boot loader in response to authentication of the first stage boot loader. The method also includes executing the second stage boot loader in response to authentication of the second stage boot loader. Executing the second stage boot loader includes loading an operating system, a first set of machine-readable instructions, and first configuration information associated with the first set of machine-readable instructions onto a non-transitory computer-readable medium, wherein the first set of machine-readable instructions and the first configuration information are associated with one or more priority partitions. Executing the second stage boot loader includes authenticating the operating system and the first set of machine-readable instructions.

Abstract: A tuned mass damper (TMD) system in combination with a floating offshore wind turbine (FOWT) platform includes a barge type FOWT platform having a hull configured to have a wind turbine tower mounted thereon. A TMD system is mounted in the hull and has a first TMD configured to operate at a first frequency, and a second TMD configured to operate at a second frequency different than the first frequency.

Abstract: A surgical instrument for use with a robotic system that has a control unit and a shaft portion that includes an electrically conductive elongated member that is attached to a portion of the robotic system. The elongated member is configured to transmit control motions from the robotic system to an end effector.

Abstract: A module builder includes a wrap floor system including a wrap floor belt wrapped around a front belt sheave and a first drive system coupled to the wrap floor system. The first drive system includes a main drive belt coupled to a rear belt sheave and the front belt sheave, wherein in an engagement mode of operation the main drive belt is tensioned to rotate the rear belt sheave, and in a disengagement mode of operation the main drive belt loses tension to cease rotation of the rear belt sheave. The builder includes a second drive system coupled to a baler belt to drive the baler belt into a module forming chamber. The first drive system further includes one or more of a rear lower gate roller, friction wheel, wrap box roller, electric clutch, or motor to engage and drive the main drive belt.

Abstract: An apparatus includes a proximal structure configured to be positioned extracorporeally relative to a patient, and a distal structure extending distally from the proximal structure and configured to be passed through a body wall and into a body cavity of the patient. The distal structure cooperates with the primary structure to define a primary axis and a working channel sized and configured to receive and guide a surgical scope shaft distally therethrough along the primary axis. The proximal structure has a greater maximum dimension in a direction transverse to the primary axis than the distal structure. The apparatus further includes an articulation feature at a distal end of the distal structure that is configured to articulate relative to the proximal structure to direct the surgical scope shaft along a secondary axis that is angled relative to the primary axis.

Abstract: The invention provides methods of increasing the efficacy of a T cell therapy in a patient in need thereof. The invention includes methods of identifying a patient who would respond well to a T cell therapy or conditioning a patient prior to a T cell therapy so that the patient responds well to a T cell therapy. The conditioning involves administering one or more preconditioning agents prior to a T cell therapy and identifying biomarker cytokines prior to administering a T cell therapy.

Abstract: A shower system includes a shower assembly and a mounting system. The shower assembly includes a reservoir configured to receive water from a water source and one or more outlets for passing water from the reservoir. The shower assembly also includes a plurality of shower mounting features provided in a first non-adjustable spatial orientation on the shower assembly. The mounting system is configured to couple the shower assembly to a building structure and adjust a position of the shower assembly relative to the building structure. The mounting system includes a bracket configured to be coupled to the building structure at a fixed position. The mounting system also includes a plurality of bracket mounting features provided in a second non-adjustable spatial orientation on the bracket and configured to align each of the plurality of bracket mounting features with one of the shower mounting features for coupling thereto.

Abstract: Methods of treating a hepatitis delta virus (HDV) infection in a human subject are provided. In some embodiments, the method comprises subcutaneously administering to the subject a therapeutically effective amount of pegylated interferon lambda-1a in combination with lonafarnib and ritonavir for at least 24 weeks. In another aspect, provided herein are methods of treating HDV infections in a subject, comprising the following drug regimen subcutaneously administering to the subject a therapeutically effective amount of pegylated interferon lambda-1a once per week, and administering lonafarnib and ritonavir daily until one or more of a sustained rHDV viral load is reached, or a decrease in HDV RNA to undetectable levels, or for 12 weeks, or for 24 weeks, or for 48 weeks.

Abstract: Some embodiments of a medical device anchor system include an anchor device that receives a medical instrument (such as a catheter or the like) and secures the instrument in place relative to a skin penetration point. In some circumstances, the anchor device may allow the anchor device to be used after medical instrument is already in place without the need for a second penetration point for the anchor device.

Abstract: In response to detecting that a remaining supply of print material of a first cartridge has reached a first threshold, a printing device transmits a request. In response to detecting that a second cartridge has replaced the first cartridge, the printing device determines whether the remaining supply had reached a second threshold and whether a token permitting usage of the second cartridge was received responsive to the request. In response to determining that the remaining supply had reached the second threshold and that the token was received, the printing device prints with print material from the second cartridge.

Abstract: Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.