Patents by Inventor Jeffrey T. Finer

Jeffrey T. Finer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions utilizing quinazolinones
    Patent number: 8658656
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: February 25, 2014
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustav S Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods and compositions utilizing quinazolinones
    Patent number: 8470838
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: June 25, 2013
    Assignee: Cytokinetics, Incorporated
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • METHODS AND COMPOSITIONS UTILIZING QUINAZOLINONES
    Publication number: 20130053408
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: September 12, 2012
    Publication date: February 28, 2013
    Inventors: Jeffrey T. Finer, Gustave S. Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Certain chemical entities, compositions and methods
    Patent number: 8293761
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: October 23, 2012
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 8063082
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: November 22, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Xiangping Qian, Jeffrey T. Finer, Pu-Ping Lu, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Methods and compostions utilizing quinazolinones
    Patent number: 8008311
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: August 30, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala
  • Certain 1H-imidazo[4,5-B]pyrazin-2(3H)-ones and 1H-imidazo[4,5-B]pyrazin-2-ols, compositions thereof, and methods for their use
    Patent number: 7956056
    Abstract: Provided is at least one chemical entity chosen from compounds of Formula I and Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: June 7, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7932270
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 26, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Pu-Ping Lu, Xiangping Qian, Jeffrey T. Finer, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • Certain chemical entities, compositions, and methods
    Patent number: 7919511
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Grant
    Filed: July 31, 2007
    Date of Patent: April 5, 2011
    Assignee: Cytokinetics, Inc.
    Inventors: Pu-Ping Lu, Xiangping Qian, Jeffrey T. Finer, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, Jr.
  • High sensitivity assay for detection of nucleoside diphosphate production
    Patent number: 7824880
    Abstract: The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or serve as modulators of the biological activity of a target protein.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: November 2, 2010
    Assignee: Cytokinetics
    Inventors: Ramesh Baliga, Donglin Guo, Daniel W. Pierce, Jeffrey T. Finer
  • Methods of screening for modulators of cell proliferation and methods of diagnosing cell proliferation states
    Publication number: 20100261160
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Application
    Filed: August 10, 2006
    Publication date: October 14, 2010
    Applicant: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • METHODS AND COMPOSTIONS UTILIZIING QUINAZOLINONES
    Publication number: 20100210670
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: February 11, 2010
    Publication date: August 19, 2010
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100210645
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 19, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Methods and compositions utilizing quinazolinones
    Patent number: 7763628
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: July 27, 2010
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustav E Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Certain Chemical Entities, Compositions and Methods
    Publication number: 20100173930
    Abstract: Provided are certain chemical entities, and methods of use to modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, neuromuscular disease, and other indications.
    Type: Application
    Filed: July 31, 2007
    Publication date: July 8, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Bradley P. Morgan, Alan James Russell, David J. Morgans, JR.
  • CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
    Publication number: 20100093741
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: October 5, 2009
    Publication date: April 15, 2010
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, JR.
  • Methods and Compositions Utilizing Quinazolinones
    Publication number: 20100063073
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: August 25, 2009
    Publication date: March 11, 2010
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols, compositions thereof, and methods for their use
    Patent number: 7598248
    Abstract: Provided is at least one chemical entity chosen from compounds of Formula I and compounds of Formula II: and pharmaceutically acceptable salts thereof, compositions thereof, and methods for their use in modulating of one or more of skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, skeletal muscle, and skeletal sarcomere.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: October 6, 2009
    Assignee: Cytokinetics, Inc.
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans, Jr.
  • Methods and compositions utilizing quinazolinones
    Patent number: 7589098
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: March 21, 2005
    Date of Patent: September 15, 2009
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • COMPOSITIONS AND ASSAYS UTILIZING ADP OR PHOSPHATE FOR DETECTING PROTEIN MODULATORS
    Publication number: 20090117534
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 7, 2009
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood