Patents by Inventor Jeffrey T. Finer

Jeffrey T. Finer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH SENSITIVITY ASSAY FOR DETECTION OF NUCLEOSIDE DIPHOSPHATE PRODUCTION
    Publication number: 20090068693
    Abstract: The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or serve as modulators of the biological activity of a target protein.
    Type: Application
    Filed: July 30, 2008
    Publication date: March 12, 2009
    Applicant: Cytokinetics, Inc.
    Inventors: Ramesh Baliga, Donglin Guo, Daniel W. Pierce, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Publication number: 20090029344
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Application
    Filed: April 28, 2008
    Publication date: January 29, 2009
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • High throughput sarcomeric assay
    Publication number: 20090023169
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 22, 2009
    Applicant: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Certain chemical entities, compositions, and methods
    Publication number: 20090012126
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: July 31, 2007
    Publication date: January 8, 2009
    Inventors: Pu-Ping Lu, Xiangping Qian, Jeffrey T. Finer, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans, JR.
  • High sensitivity assay for detection of nucleoside diphosphate production
    Patent number: 7416856
    Abstract: The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or serve as modulators of the biological activity of a target protein.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: August 26, 2008
    Assignee: Cytokinetics, Inc.
    Inventors: Ramesh Baliga, Donglin Guo, Daniel W. Pierce, Jeffrey T. Finer
  • Methods and compositions utilizing quinazolinones
    Publication number: 20080182864
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: June 28, 2007
    Publication date: July 31, 2008
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala
  • Certain chemical entities, compositions and methods
    Publication number: 20080146561
    Abstract: Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.
    Type: Application
    Filed: August 1, 2007
    Publication date: June 19, 2008
    Inventors: Alex Muci, Jeffrey T. Finer, Pu-Ping Lu, Alan James Russell, Bradley P. Morgan, David J. Morgans
  • Certain chemical entities, compositions, and methods
    Publication number: 20080146619
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, and chemical entities, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: July 31, 2007
    Publication date: June 19, 2008
    Inventors: Pu-Ping Lu, Xiangping Qian, Jeffrey T. Finer, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans
  • Certain chemical entities, compositions, and methods
    Publication number: 20080132548
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: August 1, 2007
    Publication date: June 5, 2008
    Inventors: Xiangping Qian, Jeffrey T. Finer, Pu-Ping Lu, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 7378254
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: May 27, 2008
    Assignee: Cytokinetics
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Methods and compositions utilizing quinazolinones
    Patent number: 7294634
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed.
    Type: Grant
    Filed: July 20, 2004
    Date of Patent: November 13, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods and compositions utilizing quinazolinones
    Patent number: 7230000
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 12, 2007
    Assignee: Cytokinetics, Incorporated
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods for treating congestive heart failure
    Patent number: 7214503
    Abstract: The present invention provides high throughput screening methods for characterizing compounds that modulate the biological activity of a biochemically functional sarcomere. Compounds characterized by such methods are useful for treating congestive heart failure.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: May 8, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 7202051
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: April 10, 2007
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Phenothiazine kinesin inhibitors
    Patent number: 7119089
    Abstract: Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: October 10, 2006
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, John C. Chabala
  • Phenothiazine kinesin inhibitors
    Patent number: 6992082
    Abstract: Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.
    Type: Grant
    Filed: January 18, 2002
    Date of Patent: January 31, 2006
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, John C. Chabala
  • Methods and compositions utilizing quinazolinones
    Publication number: 20040254203
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: July 20, 2004
    Publication date: December 16, 2004
    Applicant: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods of screening for modulators of cell proliferation and methods of diagnosing cell proliferation states
    Publication number: 20040214249
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Application
    Filed: June 19, 2003
    Publication date: October 28, 2004
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Phenothiazine kinesin inhibitors
    Publication number: 20040132719
    Abstract: Phenothiazine derivatives of formula (I) are disclosed. The compounds are inhibitors of the mitotic kinesin KSP and are useful in the treatment of cellular proliferative diseases, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation.
    Type: Application
    Filed: February 17, 2004
    Publication date: July 8, 2004
    Inventors: Jeffrey T Finer, John C Chabala
  • Triphenylmethane kinesin inhibitors
    Publication number: 20040132830
    Abstract: Triphenylmethane derivatives of the formula (I) are disclosed.
    Type: Application
    Filed: February 17, 2004
    Publication date: July 8, 2004
    Inventors: Jeffrey T Finer, John C Chabala, Evan Lewis