Patents by Inventor Jeffrey T. Finer

Jeffrey T. Finer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for purifying actin
    Patent number: 6759240
    Abstract: Methods for purifying actin are provided. The methods generally involve the addition of a magnesium salt in a sufficient quantity, whereby G-actin polymerizes to form actin paracrystals, which can be recovered as a purified form of actin.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: July 6, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 6743599
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 1, 2004
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • Methods and compositions utilizing quinazolinones
    Publication number: 20040023996
    Abstract: Quinazolinones of formulae (a, b, c and d) are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Application
    Filed: August 15, 2003
    Publication date: February 5, 2004
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Bainian Feng, Whitney W. Smith, John C. Chabala, David J. Morgans Jr
  • High throughput sarcomeric assay
    Publication number: 20030203835
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: April 15, 2003
    Publication date: October 30, 2003
    Applicant: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Methods and compositions utilizing quinazolinones
    Patent number: 6630479
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 7, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods of screening for modulators of cell proliferation
    Patent number: 6617115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 9, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Sarcomere protein composition
    Patent number: 6573061
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 3, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Methods and compositions utilizing quinazolinones
    Patent number: 6562831
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: May 13, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • Methods and compositions utilizing quinazolinones
    Patent number: 6545004
    Abstract: Quinazolinones of formulae 1a, 1b, 1c and 1d are disclosed. They are useful for treating cellular proliferative diseases and disorders associated with KSP kinesin activity.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: April 8, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Jeffrey T. Finer, Gustave Bergnes, Whitney W. Smith, John C. Chabala, Bainian Feng
  • High throughput sarcomeric assay
    Patent number: 6509167
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 21, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • High throughput sarcomeric assay
    Patent number: 6495337
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: December 17, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer
  • Methods of identifying modulators of kinesin motor proteins
    Patent number: 6440684
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Jeffrey T. Finer, Roman Sakowicz, Kenneth W. Wood
  • Nucleic acids encoding KSP, a kinesin motor protein
    Patent number: 6437115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 20, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Human kinesin protein KSP
    Patent number: 6414121
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 2, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Compositions and assays utilizing ADP or phosphate for detecting protein modulators
    Patent number: 6410254
    Abstract: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the cumbersome steps of using gels or radioactive materials.
    Type: Grant
    Filed: May 18, 1999
    Date of Patent: June 25, 2002
    Assignee: Cytokinetics
    Inventors: Jeffrey T. Finer, Fady Malik, Roman Sakowicz, Christopher Shumate, Kenneth Wood
  • High throughput sarcomeric assay
    Publication number: 20020022716
    Abstract: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Application
    Filed: September 26, 2001
    Publication date: February 21, 2002
    Inventors: James J. Hartman, Fady Malik, Roman Sakowicz, Jeffrey T. Finer