Abstract: New therapeutic uses of a triple agonist and/or a long-acting conjugate thereof are disclosed. The triple agonist and/or a long-acting conjugate thereof acts on all of glucagon, GLP-1 and GIP receptors, and is useful in treating multiple sclerosis. Thus, patients' options can be broadened by expanding the category of drugs applicable to multiple sclerosis and patients' convenience can be increased by significantly increasing blood half-life.

Abstract: New therapeutic uses of a triple agonist and/or a long-acting conjugate thereof are disclosed. The triple agonist and/or a long-acting conjugate thereof acts on all of glucagon receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucose-dependent insulinotropic polypeptide (GIP) receptor, and is useful in treating neurodegenerative diseases. Thus, patients’ options can be broadened by expanding the category of drugs applicable to applicable to neurodegenerative diseases, and can increase convenience for patients by significantly increasing blood half-life.

Abstract: A cathode for a lithium secondary battery based on the disclosed technology includes: a cathode current collector; and a cathode active material layer including a first cathode active material layer and a second cathode active material layer sequentially laminated on the cathode current collector, wherein the first cathode active material layer and the second cathode active material layer include first cathode active material particles and second cathode active material particles having different particle structures from each other in crystallography or morphology, and a mixing weight ratio of the second cathode active material particles to the first cathode active material particles in the first cathode active material layer may be different from a mixing weight ratio of the second cathode active material particles to the first cathode active material particles in the second cathode active material layers.

Abstract: According to an exemplary embodiment, there is provided a secondary battery in which a value of K1 represented by the following Expression (1) is 130 to 270: (200*AR+CR+20*CIR)*(1+CA)/CP??(1) in Expression (1), AR is a bulk resistance (?·cm) of the anode, CR is a bulk resistance (?·cm) of the cathode, CIR is an interfacial resistance (?·cm2) between the cathode active material layer and the cathode current collector, CP is 1?D/4.7, D is a pressed density (g/cc) of the cathode, and CA is an adhesive force (N/18 mm) between the cathode active material layer and the cathode current collector.

Abstract: A bulk acoustic resonator package includes a substrate, a cap, and first and second bulk acoustic resonators each including a first electrode, a piezoelectric layer, and a second electrode stacked in a direction in which the substrate and the cap face each other, and disposed between the substrate and the cap, wherein the first and second bulk acoustic resonators form a bandwidth based on first and second resonant frequencies different from each other and first and second antiresonant frequencies different from each other, a difference between the first and second resonant frequencies exceeds 200 MHz, the first bulk acoustic resonator is disposed closer to the substrate than to the cap, and the second bulk acoustic resonator is disposed closer to the cap than to the substrate.

Abstract: Methods of preparing a positive electrode slurry are disclosed. One example of disclosed examples includes: preparing a first mixture comprising a positive electrode active material and an acid additive; preparing a second mixture comprising a conductive material and a dispersing material; and mixing the first mixture and the second mixture.

Abstract: Disclosed are an electrode having a three-dimensional structure, the electrode including: a porous nonwoven web including a plurality of polymer fibers that form an interconnected porous network; an active material composite positioned among the polymer fibers and including active material particles and a first conductive material; and a second conductive material positioned on an outer surface of the active material composite, wherein the interconnected porous network is filled homogeneously with the active material composite and the second conductive material to form a super lattice structure, and an electrochemical device including the electrode having a three-dimensional structure.

Abstract: In a floating gate semiconductor nanostructure biosensor and a method for manufacturing the biosensor, the nanostructure biosensor includes a substrate, an insulating layer, a nanostructure, a source electrode and a drain electrode, a floating gate and a biological sensing material. The insulating layer is formed on the substrate. The nanostructure is protruded from the insulating layer. The source electrode and the drain electrode are formed on the insulating layer and dispose the nanostructure therebetween. The floating gate has a metal pattern or a polysilicon pattern, and extends with contacting the nanostructure. The biological sensing material has a first end combined with an immobile molecule on the floating gate, and a second end combined with a bio molecule.

Abstract: A binder composition for a secondary battery includes an elastic resin that includes a hard segment containing at least one of a urethane unit and a urea unit, and a soft segment containing a polyether unit, and a fluorine-based hydrocarbon resin. A weight ratio of the fluorine-based hydrocarbon resin relative to the elastic resin is in a range from 1.0 to 1.5.

Abstract: A negative electrode for a secondary battery includes a negative electrode current collector; and a negative electrode active material layer formed on the negative electrode current collector. The negative electrode active material layer includes a silicon-based active material and a conductive material. The conductive material includes carbon nanotubes having a diameter of 4 to 9 nm and 3 to 7 walls, and the carbon nanotubes are included in an amount of 3 wt % to 9 wt % with respect to a total of 100 wt % of the silicon-based active material. The negative electrode shows a negative electrode slurry resistance value of or below a predetermined value to secure excellent conductivity, and according to a manufacturing method, an effect of significantly reducing costs as compared with the conventional case is shown.

Abstract: Provided is a method for manufacturing electrode slurry including: a) kneading a first mixture including an electrode active material and a thickener solution; and b) preparing a second mixture including the kneaded first mixture and a conductive agent, in which a solid content in the second mixture is smaller than that of the first mixture.

Abstract: In a floating gate semiconductor nanostructure biosensor and a method for manufacturing the biosensor, the nanostructure biosensor includes a substrate, an insulating layer, a nanostructure, a source electrode and a drain electrode, a floating gate and a biological sensing material. The insulating layer is formed on the substrate. The nanostructure is protruded from the insulating layer. The source electrode and the drain electrode are formed on the insulating layer and dispose the nanostructure therebetween. The floating gate has a metal pattern or a polysilicon pattern, and extends with contacting the nanostructure. The biological sensing material has a first end combined with an immobile molecule on the floating gate, and a second end combined with a bio molecule.

Abstract: The present disclosure relates to a multilayer electrode for a secondary battery. The multilayer electrode for a secondary battery includes: an electrode current collector; a first mixture layer including an active material, a binder, and a single-walled carbon nanotube, the first mixture layer being formed on at least one surface of the electrode current collector; and a second mixture layer including an active material, a binder, and a multi-walled carbon nanotube, the second mixture layer being formed on the first mixture layer. According to the present disclosure, by improving the uniformity of the distribution of the conductive material in the electrode mixture layer, it is possible to prevent the resistance from increasing, and as a result, it is possible to improve the output characteristics of the secondary battery.

Abstract: Disclosed are an electrode having a three-dimensional structure, the electrode including: a porous nonwoven web including a plurality of polymer fibers that form an interconnected porous network; an active material composite positioned among the polymer fibers and including active material particles and a first conductive material; and a second conductive material positioned on an outer surface of the active material composite, wherein the interconnected porous network is filled homogeneously with the active material composite and the second conductive material to form a super lattice structure, and an electrochemical device including the electrode having a three-dimensional structure.

Abstract: A long-acting conjugate for brain targeting is disclosed. The long-acting conjugate includes a peptide for brain targeting and a physiologically active material. The long-acting conjugate contains a physiologically active material with improved durability and stability, which can pass through the blood-brain barrier (BBB) and comprises a physiologically active material. The long-acting conjugate for brain targeting including a peptide for brain targeting and a physiologically active material can pass through the blood-brain barrier, thus enabling the treatment of diseases associated with brain diseases, and additionally, can maintain the activity of a physiologically active material in vivo and increase its half-life in the blood.

Abstract: A secondary battery comprising a positive electrode current collector, a first positive electrode mixture layer disposed on the positive electrode current collector and including a first positive electrode active material and a binder, and a second positive electrode mixture layer disposed on the first positive electrode mixture layer and including a second positive electrode active material and a binder. A nickel content of the second positive electrode active material is 80% by weight or less of a nickel content of the first positive electrode active material. By providing a secondary battery including a positive electrode of a multi-layer structure that includes positive electrode active materials having different contents of nickel, a secondary battery capable of improving high-temperature characteristics while maintaining energy density may be provided.

Abstract: Provided is a novel bacterial strain Bacteroides vulgatus MGM001 (Bacteroides vulgatus MGM001) and its use. The LPS from the strain of the subject matter has cytotoxicity weaker than the conventional ones and shows synergistic effect on the inhibition of biofilm formation when used in combination with LTA.

Abstract: In a floating gate semiconductor nanostructure biosensor and a method for manufacturing the biosensor, the nanostructure biosensor includes a substrate, an insulating layer, a nanostructure, a source electrode and a drain electrode, a floating gate and a biological sensing material. The insulating layer is formed on the substrate. The nanostructure is protruded from the insulating layer. The source electrode and the drain electrode are formed on the insulating layer and dispose the nanostructure therebetween. The floating gate has a metal pattern or a polysilicon pattern, and extends with contacting the nanostructure. The biological sensing material has a first end combined with an immobile molecule on the floating gate, and a second end combined with a bio molecule.

Abstract: The present invention relates to a long-acting conjugate for brain targeting comprising a peptide for brain targeting and a physiologically active material, and to a long-acting conjugate comprising a physiologically active material with improved durability and stability, which can pass through the blood-brain barrier (BBB) and comprises a physiologically active material. The long-acting conjugate for brain targeting of the present invention comprising a peptide for brain targeting and a physiologically active material can pass through the blood-brain barrier, thus enabling the treatment of diseases associated with brain diseases, and additionally, can maintain the activity of a physiologically active material in vivo and increase its half-life in the blood.

Abstract: Single nucleotide polymorphisms (SNP) for predicting recurrence of hepatocellular carcinoma after curative surgical resection are provided. The SNPs have a significant correlation with higher risk of hepatocellular carcinoma recurrence after curative surgical resection. Therefore, the SNPs can be used in developing micro-arrays or test kits for predicting recurrence of hepatocellular carcinoma, and in screening drugs to prevent recurrence of hepatocellular carcinoma after curative surgical resection.