Abstract: The present invention relates to dihydro-cyclopenta-isoquinoline derivatives of formula (I): processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular, disorders caused by the interaction of IgE with the Fc?RI receptor.

Abstract: Compounds, such as compounds having Formula (I): wherein each variable is as described herein, that modulate the conversion of AMP to adenosine by 5?-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5?-nucleotidase, ecto is also provided.

Abstract: A non-combustible aerosol provision device for generating an aerosol from an aerosol-generating material is provided. The device includes a chamber for receiving a consumable including aerosol-generating material to enable the non-combustible aerosol provision device to generate an aerosol from the aerosol-generating material. The device further includes an adjustment mechanism to allow a user to adjust a dimension of the chamber to allow the chamber to accommodate, one at a time, each of a plurality of consumables having different sizes.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material included in a consumable, the non-combustible aerosol provision device having: a receptacle for receiving the consumable; and an adaptor configured to adapt the non-combustible aerosol provision device by varying an effective length of the receptacle such that each of a plurality consumables of different lengths, which are individually receivable in the receptacle, when received in the receptacle for use, protrude from the non-combustible aerosol provision device by substantially equal amounts.

Abstract: A non-combustible aerosol provision device for generating an aerosol from aerosol-generating material in a consumable is disclosed. The non-combustible aerosol provision device includes a retention apparatus configured to hold in position, one at a time, each of the plurality of consumables comprising aerosol-generating material of different sizes.

Abstract: An incident management system for managing an incident response may be provided. The incident management system may include an incident management (IM) computing device and a vehicle. The IM computing device may include a processor and memory, the processor may be programmed to receive a notification that an incident has occurred, the notification including sensor data and sub-system data. The processor may analyze the data to determine an incident response, the determination including categorizing the incident based on damage determined from the data. The processor may also identify a responding party based on the incident response and the category of the incident. The processor may further parse the data to generate a set of critical data. The critical data may be based on the responding party. The processor may transmit a message to the responding party including the critical data and the location of the vehicle.

Abstract: Aspects of the disclosure relate to detecting and identifying malicious sites using machine learning. A computing platform may receive a uniform resource locator (URL). The computing platform may parse and/or tokenize the URL to reduce the URL into a plurality of components. The computing platform may identify human-engineered features of the URL. The computing platform may compute a vector representation of the URL to identify deep learned features of the URL. The computing platform may concatenate the human-engineered features of the URL to the deep learned features of the URL, resulting in a concatenated vector representation. By inputting the concatenated vector representation of the URL to a URL classifier, the computing platform may compute a phish classification score. In response to determining that the phish classification score exceeds a first phish classification threshold, the computing platform may cause a cybersecurity server to perform a first action.

Abstract: Aspects of the present disclosure relate to web conference contact routing. An indication of a first participant device of a web conference attempting to contact a second participant device of the web conference can be received, where the second participant device is designated as a screen sharer within the web conference during a time of the contact and where the contact is configured to be received on a display shared in the web conference. Two or more candidate devices for routing the contact from the first participant device to can be identified. A candidate device of the two or more candidate devices for routing the contact from the first participant device to can be selected using a set of selection criteria. Contact from the first participant device can be routed to the selected candidate device instead of the display of the second participant device shared in the web conference.

Abstract: Examples of augmented reality (AR) environment control advantageously employ multi-factor intention determination and include: performing a multi-factor intention determination for summoning a control object (e.g., a menu, a keyboard, or an input panel) using a set of indications in an AR environment, the set of indications comprising a plurality of indications (e.g., two or more of a palm-facing gesture, an eye gaze, a head gaze, and a finger position simultaneously); and based on at least the set of indications indicating a summoning request by a user, displaying the control object in a position proximate to the user in the AR environment (e.g., docked to a hand of the user). Some examples continue displaying the control object while at least one indication remains, and continue displaying the control object during a timer period if one of the indications is lost.

Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A portable system for managing the temperature of a patient during transport includes a heater/cooler configured to be in fluid communication with a heat transfer catheter or a heat transfer surface pad; a pump for circulating heat exchange fluid; an alternating current power supply; and a processor configured to indicate if the alternating current power supply connection to the source of alternating current is interrupted. A rechargeable battery may be configured to provide power to the system when the alternating power supply is not connected to a source of alternating current. If the system is powered on and the connection to the alternating current source is interrupted, the system may automatically switch to receiving power from the rechargeable battery. The processor may alert an operator of the interruption of the connection to the alternating current source and indicate to the operator the amount of energy remaining in the battery.

Abstract: Aspects of the disclosure relate to detecting and identifying malicious sites using machine learning. A computing platform may receive image data of a graphical rendering of a resource available at a uniform resource locator (URL). The computing platform may compute a computer vision vector representation of the image data. The computing platform may compare the computer vision vector representation of the image data to stored numeric vectors representing page elements, resulting in a feature indicating whether the computer vision vector representation of the image data is visually similar to a known page element, and may input the feature to a classifier. The computing platform may receive, from the classifier, a phish classification score indicating a likelihood that the URL is malicious. In response to determining that the phish classification score exceeds a first phish classification threshold, the computing platform may cause a cybersecurity server to perform a first action.

Abstract: A propulsion circuit for a vehicle includes an engine, a generator, a power rectifier, a direct current (DC) bus, a propulsion battery system, and at least one converter. The generator is coupled to the engine and configured to receive an input from the engine, and to provide an alternating current (AC) output. The power rectifier is configured to receive the AC output from the generator and provide a DC output responsive to receiving the AC output. The DC bus is coupled to the rectifier. The propulsion battery system is coupled to the DC bus. The at least one converter is configured to convert a direct current to an alternating current, and is coupled to the DC bus. Further, the propulsion circuit includes at least one charging component that is configured to selectably provide a charge to the battery system via at least one of the at least one converter.

Abstract: Closed loop heat exchange catheters having bi-directional flow heat exchange regions and their methods of manufacture and use. The heat exchange region may be formed of expandable or non-expandable tubular conduit(s) that are configured in a series of loops or coiled configuration defining a supply flow path and a return flow path through which heat exchange medium is circulated. The individual loops of convolutions of the coiled configuration may be the same or different size. In some embodiments, the tubular conduit(s) may be passed through generally transverse bore holes formed in a catheter shaft so that the loops or convolutions of protrude from the catheter shaft.

Abstract: A vehicle power supply system and method may include plural vehicle contacts extending along a vehicle. At least three of the vehicle contacts may be power contacts that receive different phases of three-phase alternating current electrical power from an off-board power supply system to power the vehicle. A first power contact of the power contacts may receive a first phase of the three-phase alternating current and a second power contact of the power contacts may receive a second phase of the three-phase alternating current while the vehicle has a first orientation relative to the off-board power supply system. The first power contact may receive the second phase and the second power contact may receive the first phase while the vehicle has a second orientation relative to the off-board power supply system.

Abstract: Aspects of the disclosure relate to detecting and identifying malicious sites using machine learning. A computing platform may receive image data of a graphical rendering of a resource available at a uniform resource locator (URL). The computing platform may compute a computer vision vector representation of the image data. The computing platform may compare the computer vision vector representation of the image data to stored numeric vectors representing page elements, resulting in a feature indicating whether the computer vision vector representation of the image data is visually similar to a known page element, and may input the feature to a classifier. The computing platform may receive, from the classifier, a phish classification score indicating a likelihood that the URL is malicious. In response to determining that the phish classification score exceeds a first phish classification threshold, the computing platform may cause a cybersecurity server to perform a first action.

Abstract: Compounds that inhibit HIF-2?, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2?.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: A conformable garment or device, for example, for performing heat exchange with a patient, includes one or more tubes. At least one of the one or more tubes has a lumen configured to receive fluid for flowing through the lumen of that tube to heat or cool the tube. The one or more tubes may be coupled to form a conformable fabric or material, such that the conformable fabric or material conforms to a non-planar shape. The conformable garment or device may conform to cover a particular portion of the patient's body to heat or cool the patient's body.