Abstract: Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Abstract: A closed loop catheter useable for heat exchange is manufactured by forming a plurality of generally transverse bore holes though a flexible, multilumen catheter body, lacing a tube trough the bore holes so that loops of the tube protrude from the catheter body, connecting one end of the tube to an inflow lumen of the catheter and connecting the other end of the tube to an outflow lumen of the catheter. A heated or cooled heat exchange medium may then be circulated through the tube while the catheter is inserted in the vasculature of a subject, thereby resulting in heat exchange between the subject's flowing blood and the heat exchange medium being circulated through the tube.

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes in tension. Working fluid from the catheter is directed between the membranes. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract: A device for dispensing a material having: a first surface with an orifice; a second surface opposite the first surface; a first endface comprising an annular opening; a second endface opposite the first endface; a cavity defined by the above. An actuator is anchored to the second surface and has at least a portion of a pressing pad extending through the orifice in the first surface. An inner side of the second surface comprises a contoured portion within the cavity, the contoured portion having a first end positioned toward the second endface and a second end positioned toward the first endface, wherein the contoured portion has a maximum height at or near the first end, and a minimum height at a position between the first end and the second end.

Abstract: Methods of forming mesoporous zeolites with tunable pore widths are provided. In some embodiments, the method includes mixing a silicon-containing material, an aluminum-containing material, and at least a quaternary amine to produce a zeolite precursor solution. The zeolite precursor solution is pre-crystallized at a pre-crystallization temperature of greater than 125° C. and autogenous pressure to form a pre-crystallized zeolite precursor solution and combined with two or more distinct organosilane mesopore templates to produce a zeolite precursor gel. The zeolite precursor gel is crystallized to produce a crystalline zeolite intermediate and the crystalline zeolite intermediate is calcined to produce the mesoporous zeolite.

Abstract: Methods of forming mesoporous zeolites with tunable pore widths are provided. In some embodiments, the method includes mixing a silicon-containing material, an aluminum-containing material, and at least a quaternary amine to produce a zeolite precursor solution. The zeolite precursor solution is pre-crystallized at a pre-crystallization temperature of greater than 125° C. and autogenous pressure to form a pre-crystallized zeolite precursor solution and combined with an organosilane mesopore template to produce a zeolite precursor gel. The zeolite precursor gel is crystallized without a previous discrete functionalization step to produce a crystalline zeolite intermediate and the crystalline zeolite intermediate is calcined to produce the mesoporous zeolite. An organosilane mesopore template in accordance with is also provided, where R is an aliphatic, aromatic, or heteroatom-containing group.

Abstract: Cold plates through which refrigerant flows define a slot between them that can receive a cassette through which sterile working fluid with a relatively low flow rate flows from an intravascular heat exchange catheter. The working fluid from the catheter is heated or cooled by heat exchange with the cold plates through the walls of the cassette to maintain the sterility of the working fluid. On the other hand, high flow rate working fluid chambers surround the cold plates and non-sterile working fluid from an external heat exchange pad flows through the high flow rate working fluid chambers to exchange heat through direct contact with the cold plates.

Abstract: An optical transformer includes a light source and an array of photovoltaic cells optically coupled to the light source, where at least a portion of the photovoltaic cells are connected in series. An optical connector such as a waveguide or an optical fiber may be disposed between an output of the light source and an input of the array of photovoltaic cells. Configured to generate a high voltage output, the optical transformer may be configured to power a device such as an actuator that provides a tunable displacement as a function of voltage.

Abstract: An apparatus may control the power delivered from an AC power source to an electrical load, and may comprise a controllably conductive device. The apparatus may also comprise a controller that may be operatively coupled to a control input of the controllably conductive device. The apparatus may also include a first wireless communication circuit operable to communicate via a first protocol and to join a first wireless communication network operable to communicate via the first protocol. The first wireless communication circuit may be in communication with the controller. The controller may be operative to determine a first condition for communicating via the first protocol. The controller may also be operable to control the first wireless communication circuit to join the first wireless communication network upon the first condition being satisfied.

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes along the sides of which are disposed inlet and outlet tubes. Working fluid from the catheter is directed from the inlet tube between the membranes to the outlet tube. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract: A closed loop catheter useable for heat exchange is manufactured by forming a plurality of generally transverse bore holes though a flexible, multilumen catheter body, lacing a tube trough the bore holes so that loops of the tube protrude from the catheter body, connecting one end of the tube to an inflow lumen of the catheter and connecting the other end of the tube to an outflow lumen of the catheter. A heated or cooled heat exchange medium may then be circulated through the tube while the catheter is inserted in the vasculature of a subject, thereby resulting in heat exchange between the subject's flowing blood and the heat exchange medium being circulated through the tube.

Abstract: Cold plates through which refrigerant flows define a slot between them that can receive a cassette through which sterile working fluid with a relatively low flow rate flows from an intravascular heat exchange catheter. The working fluid from the catheter is heated or cooled by heat exchange with the cold plates through the walls of the cassette to maintain the sterility of the working fluid. On the other hand, high flow rate working fluid chambers surround the cold plates and non-sterile working fluid from an external heat exchange pad flows through the high flow rate working fluid chambers to exchange heat through direct contact with the cold plates.

Abstract: A battery system for powering a transportable thermal management system for altering or maintaining a patient's body temperature by endovascular and/or external heat exchange.

Abstract: A working fluid cassette for an intravascular heat exchange catheter includes a frame holding two closely spaced, square polymeric membranes along the sides of which are disposed inlet and outlet tubes. Working fluid from the catheter is directed from the inlet tube between the membranes to the outlet tube. The cassette is closely received between two refrigerant cold plates to exchange heat with the working fluid, which is circulated back to the catheter.

Abstract: Aspects of the disclosure relate to detecting and identifying malicious sites using machine learning. A computing platform may receive a uniform resource locator (URL). The computing platform may parse and/or tokenize the URL to reduce the URL into a plurality of components. The computing platform may identify human-engineered features of the URL. The computing platform may compute a vector representation of the URL to identify deep learned features of the URL. The computing platform may concatenate the human-engineered features of the URL to the deep learned features of the URL, resulting in a concatenated vector representation. By inputting the concatenated vector representation of the URL to a URL classifier, the computing platform may compute a phish classification score. In response to determining that the phish classification score exceeds a first phish classification threshold, the computing platform may cause a cybersecurity server to perform a first action.

Abstract: Aspects of the disclosure relate to detecting and identifying malicious sites using machine learning. A computing platform may receive image data of a graphical rendering of a resource available at a uniform resource locator (URL). The computing platform may compute a computer vision vector representation of the image data. The computing platform may compare the computer vision vector representation of the image data to stored numeric vectors representing page elements, resulting in a feature indicating whether the computer vision vector representation of the image data is visually similar to a known page element, and may input the feature to a classifier. The computing platform may receive, from the classifier, a phish classification score indicating a likelihood that the URL is malicious. In response to determining that the phish classification score exceeds a first phish classification threshold, the computing platform may cause a cybersecurity server to perform a first action.

Abstract: Closed loop heat exchange catheters having bi-directional flow heat exchange regions and their methods of manufacture and use. The heat exchange region may be formed of expandable or non-expandable tubular conduit(s) that are configured in a series of loops or coiled configuration defining a supply flow path and a return flow path through which heat exchange medium is circulated. The individual loops of convolutions of the coiled configuration may be the same or different size. In some embodiments, the tubular conduit(s) may be passed through generally transverse bore holes formed in a catheter shaft so that the loops or convolutions of protrude from the catheter shaft.

Abstract: A load control system may be commissioned using beacons. The load control system may include control devices that each include a beacon transmitting circuit configured to transmit a beacon that comprises an identifier associated with the control device. A network device, such as a mobile device, may discover a control device based on the beacon received from the control device. In response to discovery of the control device, the control device may be added to a temporary group of control devices for being collectively configured and/or controlled. Control devices may be discovered based on the signal strength at which the beacons are received. The control devices may provide feedback to a user in response to confirmation messages to indicate to a user that the lighting control device has been added to the temporary group. The control devices may stop providing the feedback after they are removed from the temporary group.

Abstract: A heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad includes a working fluid that circulates between the catheter or pad and a fluid cassette, and a refrigerant system that flows against the outer sides of cold plates between which the cassette is disposed.