Abstract: A device for performing the manipulation of particles suspended in a fluid, comprises a chamber forming a duct for the flow of the fluid, and an acoustic transducer (10) and a reflector (12) for establishing an acoustic standing wave field across the width of the duct the spacing between the transducer and reflector is 300 microns or less. With such a small spacing, the device is particularly effective at concentrating the particles and lower operating voltages are required.

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula I The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

Abstract: A digital photographic image service process comprises registration of a user data including user name, address and financial account details; capture of photographic image data in response to an activation signal generated by and/or authorized by said user; forwarding of said additional image data to an photographic e-service provider responsible for fulfilment of an order for delivery of said photographic image data, or physical prints generated therefrom; and collection of payment, by electronic means.

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 1

Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.

Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.

Abstract: A security system is disclosed which is suitable for use in a passive entry and passive starting arrangement for a vehicle 10. A set of transmitters in the form of coils A, B, C are spaced around the vehicle 10, one A, B in each door mirror 20R, 20L and one in a high level brake light 16 at the rear end.

Abstract: A method of joining and deploying two or more lengths (63,64) of underwater cable the method comprising (1) connecting together and securing the lengths of cable in cable joint (65) whereby each length of cable extends from a cable reception region (3) on one side of the cable joint, (2) attaching a deployment device (66) to the joint, (3) lowering the cable joint using the attached deployment device (66); and (4) releasing the attached deployment device (66). The cable joint can be lowered by a single deployment device only, and each length of the cable is under tension up to the cable joint when the cable joint is lowered.

Abstract: An apparatus which manipulates particles suspended in a fluid includes a duct for the flow of the fluid in which the particles are suspended, and a mechanism for establishing an acoustic standing wave field across the width of the duct, the duct being formed with an expansion in width downstream of the standing wave field. In use, the particles in the fluid are displaced into a series of parallel bands by the acoustic standing wave field. The particles remain in these bands as the fluid flows downstream from the section in which the standing wave field is present. When the fluid reaches the expansion of the duct, the stream of fluid expands accordingly in width and, in so doing, the bands of particles are spread further apart, so increasing the spacing between adjacent bands. The bands can then be observed or separated from the duct.

Abstract: A complex computing system has a plurality of nodes interconnected by channels through which data messages are exchanged. The underlying principle is that after arrival at a node of a message, delivery of that message is delayed until after delivery and consequences of all more senior messages which affect the node. The messages are progressively timestamped at each node so that each time stamp contains generation by generation indicators of the origin of the associated message. The seniority of that message is uniquely determined thereby and total ordering of the messages can be achieved. When comparing timestamps for such ordering, comparison of respective generation indicators is necessary only until there is a distinction.

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 1

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.

Abstract: This invention relates to the discovery of heterocyclic competitive inhibitors of the enzyme thrombin, their preparation, and pharmaceutical compositions thereof. As well, this invention relates to the use of such compounds and compositions in vitro as anticoagulants and in vivo as agents for the treatment and prophylaxis of thrombotic disorders such as venous thrombosis, pulmonary embolism and arterial thrombosis resulting in acute ischemic events such as myocardial infarction or cerebral infarction. Moreover, these compounds and compositions have therapeutic utility for the prevention and treatment of coagulopathies associated with coronary bypass operations as well as restenotic events following transluminal angioplasty.

Abstract: Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.

Abstract: A flip chip is soldered to an array of flexible pillars of compliant dielectric material on a circuit board. Each pillar has an electrically conductive core electrically coupled to the circuit board. The pillars absorb movement due to differences in the coefficient of thermal expansion of the chip and board, and hence reduce the possibility of fatigue failure of the solder joint. The pillars are manufactured by forming a layer of compliant dielectric material on the circuit board, forming blind holes in the layer, filling the holes with electrically conductive material overlapping the edges of the holes, and then laser ablating to remove the compliant dielectric material except where protected by the electrically conductive material.

Abstract: A vehicle security system comprises a transmitter 18 for transmitting coded signals, a receiver 16 for receiving the coded signals, and a control unit 14 for operating an engine immobilization system 12 in response to receipt by the receiver 16 of a valid coded signal. The transmitter 18 is arranged to transmit the coded signal as a sequence of pulses of electromagnetic radiation which are amplitude modulated at a modulating frequency, and the receiver includes an audio frequency filter arranged to pass signals having a frequency within a range including said modulating frequency. This allows the filtering out of high powered interfering signals which are of the same radio frequency as used in the system, but which are not modulated at the same audio frequency.

Abstract: A security system for detecting the fracture of a pane of glass of a motor vehicle comprising a fracture detector mechanisms in the form of a resilient sealing member. The resilient sealing member, which is normally in physical contact with the glass, has at least one sensor integrally formed therein by molding the at least one sensor into the resilient sealing member. The electrical state of the at least one each sensor, which is monitored by a control mechanism, is changed when the glass is fractured and, upon fracture, an appropriate warning device is energized by the control mechanism in response thereto. An anti-trap device may also be included in the resilient sealing member in order to detect the presence of foreign objects.

Abstract: Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cerebral ischemia, cerebral infarction, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, stroke, benign prosthatic hyperplasia (BPH), and diabetes.

Abstract: Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renovascular, malignant and pulmonary hypertension, cerebral infarction, myocardial ischemia, cerebral ischemia, congestire heart failure and subarachnoid hemorrhage.