Abstract: This invention relates to methods for inhibiting growth of anaerobic bacteria, particularly halitosis causing bacteria. The methods use BLIS-producing Streptococcus salivarius strains, extracts thereof, and compositions comprising same in the prevention or treatment of halitosis.

Abstract: A system and method to facilitate communication between an associated bus, such as employs a standard bus protocol, and a connector to which a removable SFF device can be attached. A desired operating mode is selected based on the device attached at the connector, such as either to pass the protocol between the bus and device generally unchanged or to implement suitable protocol conversion for such communication. Thus, by configuring the SFF device to appear as device currently supported by the bus, the SFF device can operate at the connector with native operating system support.

Abstract: Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of ?-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.

Abstract: Systems and methods for analyzing the jitter content of an oversampled digital communication signal are disclosed. Advantageously, the communication signal can correspond to an arbitrary data sequence, rather than only to a repeating test sequence. For example, the systems and methods can be embodied in test equipment and in simulation equipment as design tools and/or validation tools. The systems and methods disclosed advantageously facilitate the decomposition and quantification of the main jitter components (random and deterministic), as well as its various subcomponents (periodic jitter, data-dependent jitter, inter-symbol interference, device-state-dependent jitter, other bounded uncorrelated jitter, and data-dependent-random jitter).

Abstract: The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screening of large numbers of polypeptides in a library to identify those polypeptides which induce or antagonize receptor bioactivity. The subject assays are particularly amenable for identifying agonists and antagonists for orphan receptors. In particular the present invention makes available novel ligand agonists of human formyl peptide receptor like-1 (FPRL-1) receptors. These novel ligand agonists are used in the assays of the invention to identify modulators of FPRL-1 receptor.

Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.

Abstract: Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of ?-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.

Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.

Abstract: A dynamic compiler and method of compiling code to generate a dominate path and handle exceptions. The dynamic compiler includes an execution history recorder that is configured to record the number of times a fragment of code is interpreted. When the code is interpreted a threshold number of times, the code is queued for compilation. The execution history recorder also keeps track of where transfer of control came from and where transfer of control goes to for each fragment of code that is executed, thereby allowing for compilation of a dominant path of code. If the execution of code deviates from the dominant path of compiled code (such as when an exception occurs), a fallback interpreter is utilized to interpret the fragment of code to be executed.

Abstract: A method and system multi-threaded fragment patching. The method provides a link in a self-modifying multi-threaded computer system between a first and a second piece of compiled code where the first piece of compiled code includes a control transfer instruction to the second piece of compiled code. The link is formed by inserting a patch from the first piece of compiled code to the second piece of compiled code. The patch may be a direct reference or a reference to an outlier.

Abstract: A system and method of direct invocation of Methods using class loaders. The method includes compiling a call to and a Method of a first class (assuming that the Method is final), determining whether the second class includes an instance of the Method of the first class, determining whether the instance of the Method of the second class overrides the Method of the first class, and altering the compiled code of the Method of the first class if the instance of the Method of the second class overrides the Method of the first class.

Abstract: A method for determining the flow rate of a fluid, having a liquid fraction and a gas fraction, having the steps of: measuring the pressure and temperature of the fluid at a flow control device through which said cyrogenic fluid passes; inputting the measured pressure and Cv into an algorithm; and performing a single or multi-step iteration to determine a fluid mass flow rate of the fluid through the flow control device using the algorithm that relates the mass flow rate of the fluid to the Cv, and mass densities of the liquid fraction and the gas fraction of the fluid which are a function of the measured pressure, and temperature. A system is also provided.

Abstract: A method and system for handling device driver interrupts in a computer system. An interrupt handling Method is initiating prior to the occurrence of any interrupts in the computer system. The interrupt handling Method is executed to a waiting state, and execution is then resumed when an interrupt occurs. When an interrupt is detected control is transferred to the operating system and the interrupt is dismissed.

Abstract: A method and structure for reducing search times. The method includes examining the entries in a list in turn beginning with the entry pointed to by a start pointer and continuing until the particular entry is found. The start pointer is then reset to point at the particular entry that was found. The next search will therefore begin to search at the location where the last search ended. Such a strategy increases the likelihood of locating the particular entry faster. The list of entries includes next entry pointers that point to another entry in the list such that the next entry pointers together form a closed loop. If the entire list is searched and the particular entry is not found, the search is aborted.

Abstract: A bytecode execution system and method for increasing the execution speed of invoking and returning from Methods while minimizing the memory footprint required to support this. The system includes a virtual machine with a class loader and an interpreter or, alternatively, a hardware accelerator. Speed and memory enhancements are realized by establishing an activation stack frame template with a set of criteria. Each Method from subject code is examined to determine whether the Method conforms to the criteria of the stack frame template. If the Method conforms, an activation frame for that Method based on the activation stack frame template is created when the Method is invoked. Otherwise, an activation frame based on standard virtual machine criteria is created. An access structure is associated with each Method and a Method routing structure is created for each class.

Abstract: The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coupled receptors. Specifically, the invention provides novel yeast cells which express a heterologous G protein coupled receptor and mutant and/or chimeric G protein subunit molecules which serve to functionally integrate the heterologous into the pheromone signaling pathway of the yeast cell. The invention also provides for the expression of heterologous G protein coupled receptors which are functionally integrated into the yeast cell membrane using a yeast a factor leader sequence. Drug discovery assays using the subject yeast cells are also provided.

Abstract: A method and system of carrying out garbage collection in a computer system. Specifically, the method and system utilize low contention grey object sets for concurrent marking garbage collection. A garbage collector traces memory objects and identifies memory objects according to a three-color abstraction, identifying a memory object with a certain color if that memory object itself has been encountered by the garbage collector, but some of the objects to which the memory object refers have not yet been encountered. A packet manager organizes memory objects identified with the certain color into packets, provides services to obtain empty or partially full packets, and obtain full or partially full packets, and verifies whether a packet of the certain color is being accessed by one of the threads of the garbage collector.

Abstract: A method and a system of cache management using spatial separation of outliers. The system includes a dynamic compiler arranged to create compiled fragments of code having dominant code blocks and outliers. Memory coupled to the dynamic compiler is managed by a compiler manager such that dominant code blocks are stored in one portion of the memory and the outliers are stored in another portion of the memory. Storing the dominant path code separate from the outliers increases efficiency of the system.

Abstract: A system and method to facilitate communication between an associated bus, such as employs a standard bus protocol, and a connector to which a removable SFF device can be attached. A desired operating mode is selected based on the device attached at the connector, such as either to pass the protocol between the bus and device generally unchanged or to implement suitable protocol conversion for such communication. Thus, by configuring the SFF device to appear as device currently supported by the bus, the SFF device can operate at the connector with native operating system support.

Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.