Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: An access gateway may grant a requestor access to a computer resource. The requestor may receive a credential from an identity provider and calculate a zero-knowledge proof of possession of the credential. The requestor may use the proof to request access to the computer resource. The identity provider may record a policy corresponding to the credential in a distributed ledger. The access gateway may, subject to verifying the proof, retrieve the policy from the distributed ledger. The policy may indicate that the requestor is authorized to access the computer resource. The access gateway may grant the requestor access to the computer resource as indicated by the policy.

Abstract: An exemplary system, method and computer-accessible medium can include receiving information regarding a purchase by a person, receiving financial account information regarding a financial account associated with the person that was used to fund the purchase, generating rewards information associated with the purchase, generating an authentication token(s) based on the financial account information, sending the rewards information and the authentication token(s) over a network, and receiving a confirmation, over the network, that a rewards account associated with the person has been updated.

Abstract: An electronic aerosol provision device, the device comprising a housing for receipt of an aerosol generating component, the housing comprising an air inlet and an aerosol outlet, wherein the device is configured to induce a reduction in the temperature of an aerosol when exiting the air inlet.

Abstract: A modular storage system of connectable, heavy-duty storage boxes, crates, rolling carts and/or dollies, work surfaces, organizers, trays, accessories is provided for internal and external item storage and organization and convenient access for use and transport, that is expandable, customizable and readily adaptable. Storage boxes have different sizes by length, width and/or height and have universal box-to-box connection system for stacking and connection to mounting accessories. Boxes have removable, customizable organization inserts (e.g., dividers, storage trays, bins, alignment trays for bins, and bins of different sizes). Box lid rib grid with bosses and undercuts expands internal organization, including cooperation with dual purpose dividers and accessories. Boxes have external mounting accessories to expand external organization. Different housing modes are provided including wall mount systems for wall or side of a truck or van, and different transport modes are provided (e.g.

Abstract: The present disclosure relates to synthetic liver organoids and methods of using such synthetic liver organoids for various applications including drug discovery and modeling human liver development. In particular, provided herein are methods of producing and using synthetic mature liver organoids comprising mature, functional cells found in the human liver.

Abstract: Automated trading engine embodiments operate on market data and re-engineer trading logic to operate on computational resources that are capable of providing highly parallelized and pipelined processing operations to improve tick to trade latency. As an example, logic resources for the automated trading engine can perform multiple types of trading strategies such as (1) market making strategies that post and cancel quotes on markets, (2) aggressing strategies that place aggressing orders on markets when defined conditions are met, (3) hedging strategies that place hedging orders on markets to hedge against aggressing orders, and/or (4) canceling strategies to cancel quotes and/or orders on markets when defined conditions are met. Further still, one or more of the trading strategies can be driven by low latency derivative pricing.

Abstract: Organometallic precursors are described for the formation of high resolution lithography patterning coatings based on metal oxide hydroxide chemistry. The precursor compositions generally comprise ligands readily hydrolysable by water vapor or other OH source composition under modest conditions. The organometallic precursors generally comprise a radiation sensitive organo ligand to tin that can result in a coating that can be effective for high resolution patterning at relatively low radiation doses and is particularly useful for EUV patterning. The precursors compositions are readily processable under commercially suitable conditions. Solution phase processing with in situ hydrolysis or vapor based deposition can be used to form the coatings.

Abstract: A system includes an endoscope connector and an endoscope adapter. The endoscope connector includes a first portion. The first portion includes a first magnetic coupling element and a first planar portion that is perpendicular to an axial direction of the endoscope connector. The endoscope adapter includes a second planar portion. The second planar portion includes a second magnetic coupling element and a substantially planar surface that is perpendicular to an axial direction of the endoscope adapter. The endoscope connector is non-mechanically attachable to the endoscope adapter using the first magnetic coupling element and the second magnetic coupling element. The first planar portion is alignable with the second planar portion such that: electroconductive contacts of the endoscope connector are axially aligned with electroconductive pins of the endoscope adapter and a port of the endoscope connector is axially aligned with a corresponding insertion port of the endoscope adapter.

Abstract: Systems and methods for determining neural network brittleness are disclosed. For example, the system may include one or more memory units storing instructions and one or more processors configured to execute the instructions to perform operations. The operations may include receiving a modeling request comprising a preliminary model and a dataset. The operations may include determining a preliminary brittleness score of the preliminary model. The operations may include identifying a reference model and determining a reference brittleness score of the reference model. The operations may include comparing the preliminary brittleness score to the reference brittleness score and generating a preferred model based on the comparison. The operations may include providing the preferred model.

Abstract: A method for manufacturing an optoelectronic device including an array of diodes and photoluminescent pads arranged opposite at least one diode, including making an electret layer over the array of diodes, by localized polarization or depolarization, optically, so as to form surface potential patterns; and making the photoluminescent pads, by contact of the electret layer with a colloidal solution containing photoluminescent particles, which are then deposited over the upper face of the electret layer opposite the predefined surface potential patterns, thereby forming the photoluminescent pads.

Abstract: An example computer-implemented method for self-supervised training of an image processing model for histopathology images is provided. The example method includes obtaining a reference histopathology image; generating an augmented histopathology image, wherein generating the augmented histopathology image comprises performing, for an input image, at least one of the following augmentations: applying a blur to the input image and injecting noise artifacts into the blurred input image; or cropping a plurality of portions from the input image, wherein the plurality of portions are determined based on a minimum overlap criterion that has been updated over one or more iterations; and training the image processing model based on a similarity of latent representations generated by the image processing model respectively for the reference histopathology image and the augmented histopathology image.

Abstract: Systems and methods to facilitate cryptographic attestation chains using bonded oracles are disclosed. Exemplary implementations may publish a bond identifier that identifies a bond; record an initial attestation on a public registry, wherein the initial attestation includes an initial nonce that is based on a secret value; generate a sequence of attestations that form a chain; publish the sequence of attestations; initiate redemption of the bond, wherein the redemption is delayed by a wait period; compare individual nonces of previously published attestations to previously recorded nonces in the sequence; responsive to a match between the previously recorded nonces, publish a notification regarding nonce reuse that exposes both the secret value and the bond; responsive to exposure of the secret value, forfeit the bond identified by the bond identifier; responsive to the redemption transaction being recorded and further responsive to expiration of the wait period, redeem the bond; and/or other steps.

Abstract: A syringe containing a high water content product and for use in a drug infusion system is provided. The syringe includes a plunger carrying front and rear o-rings made of a diene rubber compound such as chlorobutyl rubber or bromobutyl rubber to impart very low gas permeability characteristics to the o-rings. The plunger may be molded as a single part or in two parts. If molded as one part with radially-engaging mold portions, the seal glands in the plunger may include parting lines from the mold. If molded as two parts with axially-engaging mold portions, the front seal gland may include a sealing surface and under cut that has no parting line. The o-rings may be surface treated with a lubricant to improve sealing where the molding process gives rise to parting lines in the seal glands, which can result in leak paths on the ID of the o-rings. The o-rings provide a gas-tight sliding seal that can withstand temperature changes from ?25° C. to 40° C.