Abstract: This disclosure relates to the combination of soluble ?-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble ?-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies.

Abstract: A system and method for providing cardiac pulmonary nerve stimulation (CPNS) with therapy titration, a goodness indicator, and therapy weaning. Therapy titration can include using physiological measurements of contractility, lusitropy, and chronotropy to determine therapy efficacy and adjust therapy delivery. For example, the electrode position and stimulation intensity can be adjusted based on the physiological measurements. Therapy titration can include closed-loop therapy delivery, in which therapy is automatically adjusted based on the measured physiological parameters. A goodness indicator can be used to monitor cardiovascular parameters such as contractility, preload, lusitropy, systolic function, and/or chronotropy. The goodness indicator can determine whether the change in these parameters from nerve stimulation is positive, and further indicate optimal stimulation. Therapy weaning can include gradually reducing stimulation while ensuring no significant reduction in therapeutic efficacy ensues.

Abstract: A method of adaptive inspection includes receiving data characterizing one or more images of an inspection region of an industrial machine acquired by an inspection system operating based on a first set of operating parameters. The inspection region includes a site feature. The method also includes determining, by an analytical model, one or more characteristics of the inspection region from the received data characterizing the one or more images of the inspection region. The method further includes generating a control signal based on the one or more characteristics of the inspection region and/or a user input. The inspection system is configured to perform a new inspection of the inspection region based on the control signal.

Abstract: Package substrates with components included in cavities of glass cores are disclosed. An example apparatus includes: a glass core having a first opening and a second opening spaced apart from the first opening, the second opening having a greater width than the first opening. The example apparatus further includes a conductive material adjacent a first wall of the first opening; and a dielectric material adjacent a second wall of the second opening.

Abstract: In some embodiments, a hybrid approach is provided for discovering devices on a network, assessing if the devices are vulnerable to security threats and malicious attacks, remediating the devices that are vulnerable, detecting security threats and malicious attacks on the network, and responding to such threats and attacks. In some implementations, a hybrid site manager for the network passively scans the network, obtains information about a network device, and actively transmits a probe to the network device based on the obtained information. In some embodiments, the hybrid site manager actively sends a probe over the network to a network device, receives a response to the probe, and modifies how it passively scans the network based on the response to the probe.

Abstract: A wearable audio device according to various implementations includes: an electro-acoustic transducer for producing sound; a proximity sensor that is configured to detect when the wearable audio device is close to a user; an internal microphone positioned within a housing of the wearable audio device and configured to detect sound in a cavity formed at least in part by a portion of the housing; and a processor that is configured to estimate, based on at least the proximity sensor, whether the wearable audio device is in place on the user's body, and to estimate, based on the internal microphone, whether the user has completed handling of the wearable audio device.

Abstract: A product for holding an item is disclosed herein. Enclosure shells can be connected together to form a v-shape surface to hold the item when opened. Legs can connect to the sides of the enclosure shells. The legs can be configured to hold up the v-shape surface platform when opened.

Abstract: The present systems and methods relate to a hand sanitizer system that includes a proximity detector, a dispensing system and an alarm feature, and is operative to identify potentially high risk hygiene situations corresponding to a person in proximity of the system failing to dispense antiseptic or other solution from the dispenser within a predetermined period of time after moving within a predetermined range of the detector.

Abstract: An electronic device provides, to a user, a user-curated playlist, the user-curated playlist including an ordered set of media items that were added by the user. While providing a first media item in the ordered set of media items, the electronic device receives a first user input selecting an option to include recommended media items in the user-curated playlist. In response to the first user input, the electronic device updates the user-curated playlist to include a first recommended media item, the first recommended media item selected without user intervention based at least in part on attributes of the user-curated playlist. The first recommended media item is positioned in the user-curated playlist in between media items that were added to the ordered set of media items by the user.

Abstract: Devices and methods used to obtain a core tissue samples are disclosed. The devices may be configured to drill into cortical bone and saw a hole into a bone lesion and/or bone marrow while obtaining the core tissue sample. The devices can include a motor and a transmission configured to rotate a trocar having a tip configured for drilling and an outer coax cannula having a cutting tip configured for sawing.

Abstract: A method and system for course assessment. The method includes: monitoring for a request to select assessors for a course by an instructor; upon receipt of a request, preparing a list of potential assessors and determining if additional potential assessors are required, if so: automatically posting a request for potential assessors; and receiving information about potential assessors; and updating the list of potential assessors; if not: proceeding; selecting assessors for the course from the list of potential assessors; assigning the select assessors to a set of students in the course, and monitoring the assigned assessors during and after the course. In some cases, the list of potential assessors is displayed to allow the instructor to select or assist with selection of the assessors. The system includes a processor and various modules configured to perform the method.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A system and method for measuring a driver's actual driving behaviors (e.g., acceleration, deceleration) in a manual driving mode to determine their preferred driving style, and then causing an autonomous or semi-autonomous vehicle to operate itself, within limits, in accordance with the drivers' driving style when operating in a self-driving mode, thereby providing a more familiar and comfortable driving experience for the driver. Data is collected on the actual driving behavior, any pre-existing data is accessed on the actual driving behavior, and the collected data and the pre-existing data are combined. A custom control is then created based upon the combined data, and the custom control is applied to manage the self-driving behavior of the autonomous or semi-autonomous vehicle in a self-driving mode. Additional data continues to be collected on the actual driving behavior, and the custom control is adjusted based upon the collected additional data.

Abstract: Exemplary embodiments may use word embeddings to enhance scanning of programming code scripts for sensitive subject matter, such as confidential subject matter. The scanning may be performed by a neural network in some exemplary embodiments. The neural network initially may be trained on a corpus of programming code scripts to identify keywords relating to sensitive subject matter, such as passwords, tokens or credentials. The neural network may not only identify instances of the keywords but also may identify related terms as well. The output of the scan may be a ranked list of terms in the programming code script that may relate to sensitive subject matter.

Abstract: Aspects of the present disclosure involve a system comprising a computer-readable storage medium storing at least one program, method, and user interfaces to facilitate communication between users via multiple modes of electronic communication. The system displays a conversation view that presents messages exchanged between a first user and at least one other user in an electronic chat conversation. The conversation view includes an interactive element to enable the first user to initiate a video call with the at least one other user. Based on receiving user input corresponding to an interaction with the interactive element, the system initiates the video call with the at least one other user. The system displays an active call view to facilitate the video call with the at least one other user. The system toggles from displaying the active call view to displaying the conversation view in response to further user input.

Abstract: In an approach to improve risk assessment and management, embodiments monitor a predetermined area by collecting, by one or more sensing devices, data related to environmental conditions and spatial relationships between one or more objects in the predetermined area. Further, embodiments determine, based on a model and the monitoring, that an accidental event is likely to occur within a predetermined distance or within the predetermined area. Additionally, embodiments identify a predetermined mitigation action from a knowledge corpus to apply to the accidental event; and proactively implementing the identified mitigation action to prevent or manage the accidental event.

Abstract: Methods, systems, and devices for a wakeup receiver operation is described. The apparatus may include a splitter that splits a received signal into a first component signal and a second component signal. The signal may include a code sequence, where each symbol of a plurality of symbols of the code sequences includes one of a set of sub-sequences. The apparatus may delay the first component signal and multiply the first component signal with the delayed first component signal and delay the second component signal and multiply the second component signal with the delayed second component signal to generate a first and second output. The apparatus may also determine a representation of the code sequence based on a sequence of levels of the first output and the second output over the plurality of symbols.

Abstract: A controller for generating a control signal for a computer-controlled machine. A neural network may be applied to a current sensor signal, the neural network being configured to map the sensor signal to a raw control signal. A projection function may be applied to the raw control signal to obtain a stable control signal to control the computer-controllable machine.

Abstract: An example form of mobile agricultural equipment generally includes a main frame, a wing frame, and a hinge mechanism. The main frame defines a track, and the wing frame has a roller rotatably mounted thereon. The hinge mechanism movably couples the main frame with the wing frame such that the wing frame is movable relative to the main frame between a first orientation and a second orientation. The hinge mechanism generally includes a sub-hinge plate pivotably coupled with the main frame, a first link pivotably coupled to each of the wing frame and the sub-hinge plate, and a second link pivotably coupled to each of the wing frame and the sub-hinge plate. The roller is configured to travel along the track during a portion of a movement of the wing frame between the first orientation and the second orientation to thereby provide support for the wing frame.