Abstract: A crystalline form A of the compound having formula (I) and uses thereof in medicine are described. Specifically, it relates to crystalline form A and pharmaceutically compositions thereof. Furthermore, it relates to the uses of crystalline form A disclosed herein and pharmaceutically compositions thereof disclosed herein in the manufacture of a medicament, especially in the manufacture of a medicament for preventing, managing, treating or lessening hepatitis C vims (HCV) infection.

Abstract: A method for managing a shared memory, including: setting a master core, applying, by the master core, to a system for idle hugepage blocks, mapping the idle hugepage blocks to a virtual address space of the master core, and sorting the hugepage blocks in an ascending order of physical address size of the hugepage blocks; dividing, depending on whether the physical addresses are continuous, the hugepage blocks sorted into segments; in response to determining that there are segments satisfying the memory demand of the subsystem, sorting the segments satisfying the memory demand of the subsystem in a descending order of lengths thereof, and remapping the sorted segments to obtain segments having both continuous virtual addresses and continuous real addresses; and in response to determine that there is a segment satisfying the memory demand of the system, releasing hugepage blocks other than the segment satisfying the memory demand of the system.

Abstract: Disclosed are a target speaker separation system, an electronic device and a storage medium. The system includes: first, performing, jointly unified modeling on a plurality of cues based a masked pre-training strategy, to boost the inference capability of a model for missing cues and enhance the representation accuracy of disturbed cues; and second, constructing a hierarchical cue modulation module. A spatial cue is introduced into a primary cue modulation module for directional enhancement of a speech of a speaker; in an intermediate cue modulation module, the speech of the speaker is enhanced on the basis of temporal coherence of a dynamic cue and an auditory signal component; a steady-state cue is introduced into an advanced cue modulation module for selective filtering; and finally, the supervised learning capability of simulation data and the unsupervised learning effect of real mixed data are sufficiently utilized.

Abstract: A full-circle secondary lining inverted arch construction formwork system for a long-distance tunnel and a formwork transporting method adopt a customized steel formwork, a steel pipe support, and a turn buckle. The steel pipe support is arranged on the longitudinal main edge, and is provided between the longitudinal rails and a primary lining for supporting vertical buoyancy. The turn buckle is arranged between two sides of the formwork and a reserved steel bar for resisting horizontal load generated during asymmetric pouring. A cantilever gantry crane and a transportation flat car are used for formwork transporting, wherein travel rails of the cantilever gantry crane and the transportation flat car are integrated on the customized steel formwork, and there is no other rail. According to the present, the formwork has high strength and rigidity, the formwork system is simple.

Abstract: A method of positioning using a shortest path based on a synthesized wideband channel estimate is described. In some embodiments, a method is disclosed, comprising: distributing an uplink schedule to a plurality of synchronized nodes; continuously capturing a reference signal across a plurality of carrier frequencies until frequency coverage for the synthetic wide band is achieved; removing frequency offset; calculating a plurality of channel estimates for the captured reference signal; aligning the plurality of channel estimates; combining the plurality of channel estimates to construct a single channel estimate of the synthetic wide band; deriving a shortest delay for the received reference signal; and using the derived shortest delay to estimate a time of arrival and thereby determine an estimated location.

Abstract: The present invention relates to use of the compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof in the manufacture of a medicament or pharmaceutical composition for preventing, treating or lessening POD,

Abstract: Disclosed are a target speaker separation system, an electronic device and a storage medium. The system includes: first, performing, jointly unified modeling on a plurality of cues based a masked pre-training strategy, to boost the inference capability of a model for missing cues and enhance the representation accuracy of disturbed cues; and second, constructing a hierarchical cue modulation module. A spatial cue is introduced into a primary cue modulation module for directional enhancement of a speech of a speaker; in an intermediate cue modulation module, the speech of the speaker is enhanced on the basis of temporal coherence of a dynamic cue and an auditory signal component; a steady-state cue is introduced into an advanced cue modulation module for selective filtering; and finally, the supervised learning capability of simulation data and the unsupervised learning effect of real mixed data are sufficiently utilized.

Abstract: The present invention relates to a salt of a compound of formula (I) and uses thereof in medicine. Specifically, it relates to maleate of compound of formula (I) and pharmaceutically compositions thereof. Furthermore, the invention relates to the uses of maleate herein and pharmaceutically compositions thereof disclosed herein in the manufacture of a medicament, especially in the manufacture of a medicament for preventing, managing, treating or lessening hepatitis C virus (HCV) infection.

Abstract: A method for managing a shared memory, including: setting a master core, applying, by the master core, to a system for idle hugepage blocks, mapping the idle hugepage blocks to a virtual address space of the master core, and sorting the hugepage blocks in an ascending order of physical address size of the hugepage blocks; dividing, depending on whether the physical addresses are continuous, the hugepage blocks sorted into segments; in response to determining that there are segments satisfying the memory demand of the subsystem, sorting the segments satisfying the memory demand of the subsystem in a descending order of lengths thereof, and remapping the sorted segments to obtain segments having both continuous virtual addresses and continuous real addresses; and in response to determine that there is a segment satisfying the memory demand of the system, releasing hugepage blocks other than the segment satisfying the memory demand of the system.

Abstract: A method of positioning using a shortest path based on a synthesized wideband channel estimate is described. In some embodiments, a method is disclosed, comprising: distributing an uplink schedule to a plurality of synchronized nodes; continuously capturing a reference signal across a plurality of carrier frequencies until frequency coverage for the synthetic wide band is achieved; removing frequency offset; calculating a plurality of channel estimates for the captured reference signal; aligning the plurality of channel estimates; combining the plurality of channel estimates to construct a single channel estimate of the synthetic wide band; deriving a shortest delay for the received reference signal; and using the derived shortest delay to estimate a time of arrival and thereby determine an estimated location.

Abstract: Various arrangements are presented for training and using a machine learning model. A first training data set may be created that has more samples but fewer dimensions than a second dataset. A second set of training data, created from the second dataset, has at least one additional dimension of data than the first set of training data. An additional dimension of data can then be simulated for the first set of training data. The simulated additional dimension of data can be incorporated with the first set of training data. A first machine learning model can be trained based on the first set of training data that comprises the simulated additional dimension of data to obtain various weights. A second machine learning model can then be trained based on the second set of training data and the obtained plurality of weights from the first trained machine learning model.

Abstract: The present disclosure provides vermicompost made of aquatic plants and a preparation method of the vermicompost. The preparation method includes: mixing aquatic plant residues and fresh cow dung according to a proportion, and crushing the aquatic plant residues while stirring until even mixing; adding earthworms to a mixture of the aquatic plant residues and the cow dung, where the earthworms transform the mixture of the aquatic plant residues and the cow dung in a forest at 15-35° C., and moisture in the mixture is maintained at 65-75% in the process; and after 35-45 days, separating the earthworms and vermicompost, and drying the vermicompost to obtain the vermicompost made of aquatic plants.

Abstract: Systems and methods are disclosed herein for blind frequency synchronization.

Abstract: Provided are a polymer medicament for treating hyperkalemia, and a preparation method thereof. Specifically, a polymer is provided, and the polymer includes repeating units obtained by polymerizing a monomer and a crosslinking agent. A molar ratio of the monomer to the crosslinking reagent ranges from 1:0.02 to 1:0.20. The monomer includes an acidic group and a pKa-reducing group next to the acidic group. The acidic group is selected from the group consisting of sulfonic acid group (—SO3—), sulfuric acid group (—OSO3—), carboxylic group (—CO2—), phosphonic acid group (—OPO32—), phosphate group (—OPO32—), and sulfamic acid group (—NHSO3—). The pKa-reducing group is selected from the group consisting of nitro, cyano, carbonyl, trifluoromethyl, and halogen atoms. The crosslinking agent has three or four reaction sites. The polymer can be used to treat hyperkalemia.

Abstract: The disclosure provides small molecule compounds, polymers, and compositions thereof, as well as methods for preparing such polymers and compositions. Also provided is a method of using the polymers or compositions thereof for binding uric acid or precursor thereof, and/or for treating hyperuricemia, gout, and/or diseases caused by hyperuricemia.

Abstract: The disclosure provides polymers and compositions thereof, as well as methods for preparing such polymers and compositions. Also provided is a method of using the polymers or compositions thereof for binding uric acid or precursor thereof, and/or for treating hyperuricemia, gout, and/or diseases caused by hyperuricemia.

Abstract: A method for facilitating a Parkinson's Disease (“PD”) assessment of a patient includes capturing first video of a patient performing first test movements while holding the mobile device; capturing second video of the patient performing second test movements while maintaining the mobile device on their person; capturing third video of the patient performing third test movements including standing and walking; capturing one or more IMU readings using an IMU of the mobile device; processing the first video, the second video, and the third video according to (i) a hand landmark model to generate one or more hand biomarkers, (ii) a face landmark model to generate one or more face biomarkers, and (iii) a body landmark model to generate one or more body biomarkers; and determining an assessment score based on a standardized PD assessment by processing the biomarkers.

Abstract: A self-organizing mesh network system is disclosed, comprising: at least one master node generating a timing reference signal; a plurality of regular nodes deriving time synchronization from the timing reference signal; and a wireless medium for communicating location and timestamp information among the plurality of regular nodes, The plurality of regular nodes may be configured to each use communicated location and timestamp information of nearby nodes to independently generate a location map of the nearby nodes. The plurality of regular nodes may be configured to accept an additional regular node. The plurality of regular nodes may be configured to allow a node of the plurality of regular nodes to exit the plurality of regular nodes. The plurality of regular nodes may each use communicated location and timestamp information of the plurality of regular nodes to independently generate a location map of each of the plurality of regular nodes.

Abstract: A rapid construction method for a secondary lining of a small-section tunnel includes steps of: transporting and store secondary lining steel bars to a designated position in the tunnel with a steel bar transport vehicle and a wheel type dump truck; after the tunnel is cleaned, simultaneously constructing the secondary lining from two ends to a middle of the tunnel; constructing a lower inverted arch with a customized inverted arch formwork and then constructing an upper arch wall with a plurality of portal arch wall formwork trolleys; wherein the portal arch wall formwork trolleys form a set, and are connected by hinges, so as to construct in a curve tunnel. The rapid construction method has a long single construction section, and procedure connection is compact, thereby realizing rapid and efficient construction of the secondary lining.

Abstract: A method of treating or preventing a Coronaviridae infection in a subject comprising administrating a therapeutically effective amount of a compound of Formula I or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the Coronaviridae comprises at least one selected from 2019-nCov virus, HCov 229E virus, SARS virus, MERS virus,