Abstract: The present disclosure discloses an optical imaging system including, sequentially from an object side to an image side along an optical axis, a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, and a seventh lens. Each of the first lens to seventh lens has refractive power. An object-side surface of the first lens is concave, and an image-side surface thereof is concave; an object-side surface of the second lens is convex, and an image-side surface thereof is convex; and an object-side surface of the third lens is concave, and an image-side surface thereof is convex. An effective focal length f4 of the fourth lens and a total effective focal length f of the optical imaging system satisfy ?2.0<f4/f<?1.5. Half of a maximal field-of-view Semi-FOV of the optical imaging system satisfies Semi-FOV?55°.

Abstract: This application relates to the field of wireless communications technologies, and discloses an encoding method and apparatus, to improve accuracy of reliability calculation and ordering for polarized channels. The method includes: obtaining a first sequence used to encode K to-be-encoded bits, where the first sequence includes sequence numbers of N polarized channels, the first sequence is same as a second sequence or a subset of the second sequence, the second sequence comprises sequence numbers of Nmax polarized channels, and the second sequence is the sequence shown in Sequence Q11 or Table Q11, K is a positive integer, N is a positive integer power of 2, n is equal to or greater than 5, K?N, Nmax=1024; selecting sequence numbers of K polarized channels from the first sequence; and performing polar code encoding on K the to-be-encoded bits based on the selected sequence numbers of the K polarized channels.

Abstract: Methods for detecting a glitch at a high sampling rate are provided. In some embodiments, a method includes the following steps: S1, acquiring to-be-identified data; S2, processing the to-be-identified data to obtain normal sampling data; and S3, performing glitch identification on the to-be-identified data to obtain a glitch position of the normal sampling data. In other embodiments, the disclosure provides a system for detecting a glitch at a high sampling rate and for implementing the method for detecting a glitch at a high sampling rate. The system includes an acquisition unit and a glitch identification unit. The acquisition unit acquires and processes the to-be-identified data to obtain the normal sampling data, and the glitch identification unit performs glitch identification on the to-be-identified data to obtain the glitch position of the normal sampling data.

Abstract: A modified cutinase is disclosed. The cutinase has the modified amino acid sequence of SEQ ID NO: 2, wherein the modification is a substitution of asparagine at position 181 with alanine, or substitutions of asparagine at position 181 with alanine and phenylalanine at position 235 with leucine. The modified enzyme has improved PET-hydrolytic activity, and thus, the high-activity PET hydrolase is obtained, and the industrial application value of the PET hydrolase is enhanced.

Abstract: A package device can include: a package body having a support body and an encapsulating body configured to encapsulate a conductive body of the package device; at least one extraction electrode electrically connected to the conductive body, and having a part exposed outside the package body; and where the support body is located on only part of a bottom surface of the encapsulating body, and protrudes from the bottom surface of the encapsulating body to form a cavity defined by the remaining exposed bottom surface of the encapsulating body and inner side surface of the supporting body.

Abstract: Described herein are T cells engineered to express a chimeric antigen receptor (CAR), such as an anti-mesothelin CAR alone or in combination with a follicle-stimulating hormone receptor (FSHR) binding domain and/or a dominant negative transforming growth factor-? receptor II (dnTGF?RII) for the treatment of diseases associated with mesothelin expression. Also described are T cells engineered to express a modified T cell receptor (TCR).

Abstract: The present invention provides a high temperature chemical solution supply system for cleaning substrates. The system includes a solution tank, a buffer tank, a first pump and a second pump. The solution tank contains high temperature chemical solution. The buffer tank has a tank body, a vent line and a needle valve. The tank body contains the high temperature chemical solution. An end of the vent line connects to the tank body, and the other end of the vent line connects to the solution tank. The needle valve is mounted on the vent line, wherein the needle valve is adjusted to reach a flow rate to vent gas bubbles inside of the high temperature chemical solution out of the buffer tank through the vent line. An inlet of the first pump connects to the solution tank, and an outlet of the first pump connects to the buffer tank. An inlet of the second pump connects to the buffer tank, and an outlet of the second pump connects to a cleaning chamber in which a substrate is cleaned.

Abstract: A method and system for predicting a treatment outcome. Three-dimensional imaging data for a retina of a subject is received. A first output is generated using a deep learning system and the three-dimensional imaging data. The first output and baseline data are received as input for a symbolic model. A treatment outcome is predicted, via the symbolic model, for the subject undergoing a treatment for neovascular age-related macular degeneration (nAMD) using the input.

Abstract: A method and system for managing a treatment for a subject diagnosed with neovascular age-related macular degeneration (nAMD). Spectral domain optical coherence tomography (SD-OCT) imaging data of a retina of the subject is received. Retinal feature data is extracted for a plurality of retinal features using the SD-OCT imaging data, the plurality of retinal features being associated with at least one of a set of retinal fluids or a set of retinal layers. Input data formed using the retinal feature data for the plurality of retinal features is sent into a first machine learning model. A treatment level for an anti-vascular endothelial growth factor (anti-VEGF) treatment to be administered to the subject is predicted, via the first machine learning model, based on the input data.

Abstract: Embodiments of the present disclosure provide a method for forming a hole structure in a semiconductor device. The method for forming a hole structure having a first hole portion and a second hole portion connected to and over the first portion in a stack structure of a semiconductor device includes determining a hard mask layer. An etching resistivity of the hard mask layer may be inversely proportional to a difference between a first lateral dimension of the first hole portion and a second lateral dimension of the second hole portion, and the first lateral dimension may be less than the second lateral dimension. The method may also include forming the hard mask layer over the stack structure, and patterning the hard mask layer to form a first patterned hard mask layer that has a first mask opening. The first mask opening may have the first lateral dimension.

Abstract: The present invention discloses an item locating and finding method, system and device based on acoustic signal, which relates to the field of item location, and aims at solving the problems in the prior art that a specific directional angle of the item cannot be detected and the technical solutions in the prior art are not suitable for common intelligent terminals and are greatly affected by the environmental noise; performing unilateral and bidirectional ranging based on the acoustic signal; and performing location by using acoustic ranging and PDR.

Abstract: The present invention discloses an item locating and finding method, system and device based on acoustic signal, which relates to the field of item location, and aims at solving the problems in the prior art that a specific directional angle of the item cannot be detected and the technical solutions in the prior art are not suitable for common intelligent terminals and are greatly affected by the environmental noise; performing unilateral and bidirectional ranging based on the acoustic signal; and performing location by using acoustic ranging and PDR.

Abstract: A halogen-free flame-retardant polyamide (PA) composite includes the following components in parts by weight: 20 to 50 parts of an aliphatic PA, 10 to 30 parts of an aromatic PA, 20 to 30 parts of a halogen-free flame retardant, 10 to 50 parts of a glass fiber, 1 to 5 parts of a char-forming agent, and 0 to 5 parts of an additive, where the aromatic PA is at least one selected from the group consisting of PA66/6T, PA MXD6, and PA6T/6I and the char-forming agent is at least one selected from the group consisting of dipentaerythritol (DPE) and tripentaerythritol (TPE). In the halogen-free flame-retardant PA composite, the aromatic PA itself has high-temperature resistance and aging resistance and exhibits a synergistic effect with a dense carbon layer formed by the char-forming agent during aging. The present disclosure discloses a preparation method of the halogen-free flame-retardant PA composite.

Abstract: Embodiments of the present disclosure provide a method for forming a hole structure in a semiconductor device. The method includes forming a first etch mask over a stack structure, and removing a portion of the stack structure exposed by the first etch mask. The first etch mask may have a first mask opening with a first lateral dimension. The method may also include forming a second etch mask from the first etch mask. The second etch mask may have a second mask opening with a second lateral dimension that is greater than the first lateral dimension. The method may further include removing another portion of the stack structure exposed by the second etch mask to form the hole structure having a first hole portion and a second hole portion connected to and over the first hole portion.

Abstract: Systems and methods relate to processing digital pathology mages. More specifically, depictions of objects of a first class (e.g., lymphocytes) and depictions of objects of a second class (e.g., tumor cells) are detected. Locations of each biological object depiction are identified, which are used to generate multiple spatial-distribution metrics that characterize where depictions of objects of a first class are located relative to objects of a second class. The spatial-distribution metrics are used to generate a result corresponding to a predicted biological state of or a potential treatment of a subject. For example, the result may predict whether and/or an extent to which lymphocytes have infiltrated a tumor, whether checkpoint blockade therapy would be an effective treatment for the subject, and/or whether a subject is eligible for a clinical trial.

Abstract: A method for analyzing arrhythmia in real time and an electrocardiogram monitoring device is disclosed. The method for analyzing arrhythmia in real time includes: acquiring a QRS template set currently used for arrhythmia analysis; determining whether each QRS template in the QRS template set is reliable; displaying information of a QRS template when the QRS template set contains an unreliable QRS template; determining the QRS template set according to an operation performed by a user on the information of the QRS template; and acquiring real-time electrocardiogram data, performing arrhythmia analysis on the real-time electrocardiogram data by using a determined QRS template set, and outputting an arrhythmia analysis result of the real-time electrocardiogram data in real time. The method for analyzing arrhythmia in real time may achieve the correction of a template of a special waveform by means of editing a currently created QRS template.

Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: Systems and methods relate to processing optical tomography coherence (OCT) images to predict characteristics of a treatment to be administered to effectively treat age-related macular degeneration. The processing can include pre-processing the image by flattening and/or cropping the image and processing the pre-processed image using a neural network. The neural network can include a deep convolutional neural network. An output of the neural network can indicate a predicted frequency and/or interval at which a treatment (e.g., anti-vascular endothelial growth factor therapy) is to be administered so as to prevent leakage of vasculature in the eye.

Abstract: The present invention provides a polyamide composite, including the following components: 20 to 80 parts of a polyamide resin; 1 to 30 parts of a red phosphorus flame retardant; 0.01 to 10 parts of trimethallyl isocyanurate; and the polyamide composite has a cross-linked structure between polyamide molecules. By adding trimethallyl isocyanurate (TMAIC) for irradiation cross-linking treatment, and by the red phosphorus flame retardant, not only the polyamide composite can meet the needs of flame retardant, but also glow-wire ignition temperature (GWIT) and comparative tracking index (CTI) have been improved.

Abstract: Systems and methods disclosed herein relate to using a machine-learning model to process an input of a subject's eye and to predict a current or future visual acuity of the subject. The subject may have been diagnosed with age-related macular degeneration. The predicted current or future visual acuity may be used to (for example) facilitate diagnosing the subject (e.g., with a particular type of age-related macular degeneration), facilitate identifying a treatment strategy for the subject, and/or facilitate designing a clinical study.