Abstract: Embodiments of the present disclosure provide a method for forming a hole structure in a semiconductor device. The method includes forming a first etch mask over a stack structure, and removing a portion of the stack structure exposed by the first etch mask. The first etch mask may have a first mask opening with a first lateral dimension. The method may also include forming a second etch mask from the first etch mask. The second etch mask may have a second mask opening with a second lateral dimension that is greater than the first lateral dimension. The method may further include removing another portion of the stack structure exposed by the second etch mask to form the hole structure having a first hole portion and a second hole portion connected to and over the first hole portion.

Abstract: Systems and methods relate to processing digital pathology mages. More specifically, depictions of objects of a first class (e.g., lymphocytes) and depictions of objects of a second class (e.g., tumor cells) are detected. Locations of each biological object depiction are identified, which are used to generate multiple spatial-distribution metrics that characterize where depictions of objects of a first class are located relative to objects of a second class. The spatial-distribution metrics are used to generate a result corresponding to a predicted biological state of or a potential treatment of a subject. For example, the result may predict whether and/or an extent to which lymphocytes have infiltrated a tumor, whether checkpoint blockade therapy would be an effective treatment for the subject, and/or whether a subject is eligible for a clinical trial.

Abstract: A method for analyzing arrhythmia in real time and an electrocardiogram monitoring device is disclosed. The method for analyzing arrhythmia in real time includes: acquiring a QRS template set currently used for arrhythmia analysis; determining whether each QRS template in the QRS template set is reliable; displaying information of a QRS template when the QRS template set contains an unreliable QRS template; determining the QRS template set according to an operation performed by a user on the information of the QRS template; and acquiring real-time electrocardiogram data, performing arrhythmia analysis on the real-time electrocardiogram data by using a determined QRS template set, and outputting an arrhythmia analysis result of the real-time electrocardiogram data in real time. The method for analyzing arrhythmia in real time may achieve the correction of a template of a special waveform by means of editing a currently created QRS template.

Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: The present invention provides a polyamide composite, including the following components: 20 to 80 parts of a polyamide resin; 1 to 30 parts of a red phosphorus flame retardant; 0.01 to 10 parts of trimethallyl isocyanurate; and the polyamide composite has a cross-linked structure between polyamide molecules. By adding trimethallyl isocyanurate (TMAIC) for irradiation cross-linking treatment, and by the red phosphorus flame retardant, not only the polyamide composite can meet the needs of flame retardant, but also glow-wire ignition temperature (GWIT) and comparative tracking index (CTI) have been improved.

Abstract: Systems and methods relate to processing optical tomography coherence (OCT) images to predict characteristics of a treatment to be administered to effectively treat age-related macular degeneration. The processing can include pre-processing the image by flattening and/or cropping the image and processing the pre-processed image using a neural network. The neural network can include a deep convolutional neural network. An output of the neural network can indicate a predicted frequency and/or interval at which a treatment (e.g., anti-vascular endothelial growth factor therapy) is to be administered so as to prevent leakage of vasculature in the eye.

Abstract: Systems and methods disclosed herein relate to using a machine-learning model to process an input of a subject's eye and to predict a current or future visual acuity of the subject. The subject may have been diagnosed with age-related macular degeneration. The predicted current or future visual acuity may be used to (for example) facilitate diagnosing the subject (e.g., with a particular type of age-related macular degeneration), facilitate identifying a treatment strategy for the subject, and/or facilitate designing a clinical study.

Abstract: The present disclosure discloses a conjugate compound or a pharmaceutically acceptable salt thereof, comprising a payload and two targeting molecules. Further disclosed herein is a pharmaceutical composition, comprising the conjugate compound or the pharmaceutically acceptable salt thereof. The present disclosure additionally relates to a method for delivering a payload to a subject in need thereof, and a method for treating a disease, wherein the methods comprise administering to the subject a therapeutically effective amount of the conjugate compound or the pharmaceutically acceptable salt thereof, or the pharmaceutical composition as disclosed herein.

Abstract: Disclosed are a monitoring apparatus and a method for operating same, a monitor and a computer storage medium. During the process of monitoring a monitored object, a monitoring signal of the monitored object is acquired in real time by a sensor accessory connected to the monitored object; monitoring parameter of the monitored object is obtained according to the monitoring signal, and the monitoring parameter is analyzed according to a first data analysis function. When the monitoring parameter satisfies a preset condition, a second data analysis function for at least one type of physiological parameter of the monitored object is turned on or off. Thus, a monitoring function for a physiological parameter of a monitored object can be turned on or off according to the current monitoring parameter of the monitored object, such that a monitored physiological parameter can be adaptively adjusted, thereby improving the monitoring quality.

Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.

Abstract: A method of spectroscopically measuring percent glycated hemoglobin or a glycated hemoglobin:total hemoglobin ratio in a biological sample is disclosed. The method includes the use of a turbidity normalization algorithm to normalize the total hemoglobin concentration calculated from the spectroscopic measurements to substantially remove any turbidity interference therefrom. The turbidity normalization eliminates the negative bias observed with intralipid/lipemia and thus provides a glycated hemoglobin assay with no significant interference from intralipid/lipemia.

Abstract: An alarm threshold setting suggestion method, a system and a monitor are provided in the disclosure. The method includes: obtaining monitoring data of a patient, determining whether the current alarm threshold associated with a monitoring parameter needs to be adjusted or not according to the monitoring data, and if yes, generating threshold setting suggestion information according to the monitoring data and the current alarm threshold associated with the monitoring parameter; and outputting the threshold setting suggestion information. In this way, not only is the user prompted to adjust the alarm threshold, but also the threshold setting suggestion information is provided for user reference, which are beneficial to relieving the problem of alarm fatigue.

Abstract: A method for analyzing arrhythmia in real time and an electrocardiogram monitoring device is disclosed. The method for analyzing arrhythmia in real time includes: acquiring a QRS template set currently used for arrhythmia analysis; determining whether each QRS template in the QRS template set is reliable; displaying information of a QRS template when the QRS template set contains an unreliable QRS template; determining the QRS template set according to an operation performed by a user on the information of the QRS template; and acquiring real-time electrocardiogram data, performing arrhythmia analysis on the real-time electrocardiogram data by using a determined QRS template set, and outputting an arrhythmia analysis result of the real-time electrocardiogram data in real time. The method for analyzing arrhythmia in real time may achieve the correction of a template of a special waveform by means of editing a currently created QRS template.

Abstract: Embodiments of the present disclosure provide a method for forming a hole structure in a semiconductor device. The method for forming a hole structure having a first hole portion and a second hole portion connected to and over the first portion in a stack structure of a semiconductor device includes determining a hard mask layer. An etching resistivity of the hard mask layer may be inversely proportional to a difference between a first lateral dimension of the first hole portion and a second lateral dimension of the second hole portion, and the first lateral dimension may be less than the second lateral dimension. The method may also include forming the hard mask layer over the stack structure, and patterning the hard mask layer to form a first patterned hard mask layer that has a first mask opening. The first mask opening may have the first lateral dimension.

Abstract: Embodiments of the present disclosure provide a method for forming a hole structure in a semiconductor device. The method includes forming a first etch mask over a stack structure, and removing a portion of the stack structure exposed by the first etch mask. The first etch mask may have a first mask opening with a first lateral dimension. The method may also include forming a second etch mask from the first etch mask. The second etch mask may have a second mask opening with a second lateral dimension that is greater than the first lateral dimension. The method may further include removing another portion of the stack structure exposed by the second etch mask to form the hole structure having a first hole portion and a second hole portion connected to and over the first hole portion.

Abstract: A power conversion system is disclosed, which comprises at least one conversion unit comprising a converter unit and a first power interface boards; at least one measurement unit comprising a measurement board and a second power interface boards; and a controller comprising a processing unit, and a third power interface board communicated with the processing unit, and the first power interface board and the second power interface board, wherein at least some of the communications between the third power interface board and the first and second power interface boards have independent bandwidths.

Abstract: A conjugate compounds or pharmaceutically acceptable salt thereof, comprises a payload and two or more kinds of cell-interacting molecules. The cell-interacting molecules are ligands capable of specifically binding to a cell surface receptor. A method of treating diseases, comprises delivering a payload to a subject.

Abstract: A power conversion system may include a plurality of power devices and a sensor operably coupled to at least one of the plurality of power devices and configured to detect a voltage, current, or electromagnetic signature signal associated with the plurality of power devices. The power converter may also include circuitry operably coupled to the plurality of power devices and the sensor. The circuitry may send a respective gate signal to each respective power device of the plurality of power devices, such that each respective gate signal is delayed by a respective compensation delay that is determined for the respective power device based on a respective time delay of the respective power device and a maximum time delay of the plurality of power devices.

Abstract: A method for automated test case augmentation includes receiving, at an automated test augmentation system, a design model and model coverage gap information from a model-based development tool, translating the model coverage gap information into machine-readable mathematical test objective expressions, developing a set of test objective operators by translating the machine-readable mathematical test objective expressions, localizing target operators for the identified coverage gaps within the design model, attaching the test objective operators to target operators of the design model to create a test model, augmenting the test model by propagating test objectives at the target operators to a test node operator of the design model, and executing, by a test generator, the augmented test model to obtain the test cases to cover the coverage gaps and the causes for the model coverage gaps. A system for implementing the model-based design and a non-transitory computer readable medium are also disclosed.

Abstract: A method for automated test case augmentation includes receiving, at an automated test augmentation system, a design model and model coverage gap information from a model-based development tool, translating the model coverage gap information into machine-readable mathematical test objective expressions, developing a set of test objective operators by translating the machine-readable mathematical test objective expressions, localizing target operators for the identified coverage gaps within the design model, attaching the test objective operators to target operators of the design model to create a test model, augmenting the test model by propagating test objectives at the target operators to a test node operator of the design model, and executing, by a test generator, the augmented test model to obtain the test cases to cover the coverage gaps and the causes for the model coverage gaps. A system for implementing the model-based design and a non-transitory computer readable medium are also disclosed.