Abstract: The present disclosure discloses a miniaturized MOPA structure DPSSL (Diode Pumped Solid State Laser), which comprises a laser oscillator module and a laser amplifier module. The laser oscillator module consists of a seed laser and its collimating system, and the laser amplifier module consists of a laser pump module and a laser gain element. The seed laser with high beam quality is collimated by a collimation system, then input into the gain element; the pump laser is pumped into the gain element via end pump or side pump mode. The seed laser beam transmits into the gain medium and is reflected by the interface several times with the “Zigzag” path, which makes the seed laser fully gained and amplified, finally achieving high power and high beam quality laser output. In this present disclosure, the laser gain material is doped with different rare-earth ion concentrations and processed into different shapes.

Abstract: Provided is a pitting detection and residual strength calculation methods and systems for multi-arm caliper logging data. The method includes the following steps.

Abstract: Provided are a cyclic 2-aminopyrimidine compound having a structure as shown in formula (I), or a pharmaceutically acceptable salt, stereoisomer or prodrug molecule thereof, and a use thereof. The compound can effectively inhibit the activity of EGFR protein kinase drug-resistant mutants (such as EGFRT790M and EGFR19del/T790M/C797S), and can overcome the clinical drug resistance of patients suffering from tumors such as non-small cell lung cancer induced by existing third-generation selective EGFRT790M small molecule inhibitors Osimertinib (AZD9291), Olmutinib (HM6171), Rociletinib (CO-1686) and the like.

Abstract: The present application provides a method and system for automated inspection of a microfabricated feature on a substrate. The disclosure utilizes manipulating laser polarization in combination with the excitation and emission process, in inspection applications. The application specifically discloses selecting the polarization of the laser light by adjusting a polarization manipulator or a quarter-waveplate and/or a half waveplate between the laser source and the substrate to impart polarization to the laser light. The polarization impacts using a polarization selected to improve fluorescence emission of certain features on a substrate. The selection can be made prior to run time or dynamically during the inspection tool runtime. If the polarization is not specifically selected, then the microfabricated features may not emit much fluorescence.

Abstract: A stent for aorta is formed by weaving at least two types of filaments having different diameters, such as a first filament and a second filament. The stent is configured to be at least partially compressible and extensible along the axial direction of the stent in a natural release state, wherein the first filament has a diameter of 20-150 ?m, and the second filament has a diameter of 150-800 ?m. When the stent is used in the treatment of aortic aneurysm and/or aortic dissection lesions, due to the axial compressibility and extensibility of the stent, low liquid permeability and strong radial support force are provided where needed in the aorta, and due to the axial stretchability thereof, the stent can be easily assembled to a delivery system having an appropriate diameter. Also provided are a stent kit comprising the stent and a stent delivery system.

Abstract: Provided is the use of a CSF1R kinase inhibitor compound or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases related to the CSF1R kinase signal transduction pathway or drugs for regulating immunization.

Abstract: An intracavity frequency-doubling laser device includes a first mirror and a second mirror defining a resonance cavity, a gain media to produce a first lasing light in response to an external pump beam received from outside the cavity, a nonlinear frequency-doubling optical element to generate a second lasing light in response to the first lasing light, a birefringent waveplate to control phase properties of the first and second lasing lights, and a fused quartz element positioned at the exit of the resonance cavity. The second mirror is formed as a relatively thick film on the fused quartz and is controlled to create an output beam of the second lasing light with great accuracy. The four components within the resonance cavity are positioned back-to-back and held in place using an optical glue (forming a compact, miniaturized laser device).

Abstract: A power converter includes a power controller and the power conversion circuit. The power conversion circuit includes a first power transistor. The power controller is configured to: when the first power transistor is in an on state, receive an instruction of stopping sending a pulse width modulation (PWM) driver gating signal, where the instruction of stopping sending a PWM driver gating signal instructs to perform control over stopping sending a PWM driver gating signal on the first power transistor; and when a specified condition is met, perform, according to the instruction of stopping sending a PWM driver gating signal, control over stopping sending a PWM driver gating signal on the first power transistor, where the specified condition is that a drive signal of the first power transistor is a turn-off signal.

Abstract: Techniques for inspecting a substrate can include scanning the substrate across a plurality of scan positions using an interrogation beam having a width substantially equal to or greater than a diameter of at least one surface feature on a surface of the substrate to generate scanning results. A set of raw centroid calculation results can be generated based on the scanning results. An error property can be determined and removed from the raw centroid calculation results to generated refined centroid calculation results. A characteristic of the surface feature can be determined based on the centroid calculation results.

Abstract: Use of a compound of general formula (A) which is a CFS-IR kinase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of medicaments for treating diseases related to CSF-1R kinase signal transduction pathway or medicaments for regulating immunization. In vivo and in vitro studies show that the compound can significantly inhibit CSF-IR kinase activity; significantly inhibits the proliferation of a CSF-1/CSF-1R-driven mouse myeloid leukemia cell line, inhibits the survival of macrophages induced by CSF-1 and reverses M2 polarization phenotype of macrophages, and has an effect superior to that of the marketed medicament Pexidartinib. In a TAM enriched tumor model (MC38 model), the compound significantly antagonizes the tumor immunosuppressive microenvironment and exhibits significant anti-tumor efficacy.

Abstract: An axially compressible bare stent for an aorta, formed by interleaving at least two wires having different diameters, i.e., a first wire and a second wire, in an overlapping manner. In a natural release state, the bare stent has a metal coverage of at least 30%. The first wire has a diameter of 20-150 ?m, and the second wire has a diameter of 150-600 ?m. During the use in the treatment of aortic aneurysms and/or aortic dissection lesions, low liquid permeability and a strong radial support force are provided at a desired location in an aorta by means of the axial compressibility of the bare stent.

Abstract: Various examples described herein include various mechanisms, techniques, and methods to subtract collected signals caused by a periodic pattern formed on substrates to enable a higher level of defect detection on substrates. Signals detected by various types of metrology and substrate-inspection systems that are caused by periodic patterns on inspected substrates can be reduced or eliminated by, for example, a Fourier analysis of the detected signals. Both gray-scale value thresholds and area thresholds may be applied after the Fourier analysis of the image and are sufficient for defect detection on an image with a substantially-reduced number of false defects or no defects being present in a final image produced after processing. Other techniques and methods are also disclosed.

Abstract: A disproportionation and transalkylation catalyst can be used in the catalytic conversion of alkyl aromatic hydrocarbons. The catalyst contains an acidic molecular sieve, a first metal component immobilized on the acidic molecular sieve and an oxide additive. The first metal contained in the first metal component is at least one selected from the group of Group VB metals, Group VIB metals and Group VIIB metals, the catalyst has a medium strong acid content of 0.05-2.0 mmol/g of catalyst, and a ratio of the medium strong acid content to the total acid content of 60-99%. When used in the catalytic conversion of alkyl aromatic hydrocarbons, the catalyst exhibits high reaction activity, low aromatic hydrocarbon loss rate.

Abstract: An electronic device, pertaining to the field of communications technologies are provided. The electronic device includes: a display bracket; a speaker bracket, where the speaker bracket is disposed on the display bracket; a speaker, where the speaker is disposed on the speaker bracket, and the speaker is located on a side of the speaker bracket back away from the display bracket; and a main board bracket, where the main board bracket is connected to the display bracket, and the speaker bracket and the speaker are both located between the display bracket and the main board bracket. The speaker bracket, the speaker, and the main board bracket jointly create a closed rear cavity.

Abstract: Provided are a class of fused-cyclic pyrazolone formamide compounds and a preparation method therefor, a pharmaceutical composition and the use thereof. Specifically, provided is a compound having the structure as shown in formula (I) (with each group defined in the description). The compound can be used as an AXL inhibitor in the preparation of a pharmaceutical composition for treating tumors.

Abstract: Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.

Abstract: A compound having Axl and c-Met kinase inhibitory activity, a preparation method therefor and an application thereof are provided. Specifically, provided herein are a compound having the structure represented by formula (I), a preparation method therefor and an application thereof in the preparation of a medication for the treatment and/or prevention of tumor-associated diseases and/or kinase-related diseases.

Abstract: The present disclosure provides compositions and methods for treating and preventing macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). The method entails administering to the patient in need thereof an antibody or fragment thereof having specificity to a human GM-CSF protein.