Abstract: The present invention relates to a mannuronic diacid oligosaccharide composition, comprising a mannuronic diacid of Formula (III) or a pharmaceutically acceptable salt thereof, wherein n is an integer from 1 to 9, m is 0, 1 or 2, and m? is 0 or 1, and wherein the total weight of mannuronic diacids wherein n=1-5 is 80-95% of the total weight of the composition, and the ratio of the total weight of mannuronic diacids wherein n=1-3 to the total weight of mannuronic diacids wherein n=4-7 is between 1.0 and 3.5.

Abstract: Disclosed herein are techniques to reduce blurring in images taken during semiconductor inspection. A stage, which holds a substrate for inspection, can move at a substantially constant speed during inspection to increase throughput. In some techniques, a mirror system can be added to the camera system for reducing blur in images. The mirror system can include a rotating or dithering mirror to translate the linear motion of the stage into a counter rotational motion in the form of deflecting beam angles thereby reducing the motion blur caused by the movement of the stage.

Abstract: This application discloses an electronic device, which includes a first bracket and a second bracket arranged opposite each other, as well as a circuit board, a loudspeaker unit, and an enclosing assembly that are located between the first bracket and the second bracket. The circuit board has a first notch, and the loudspeaker unit is arranged in the first notch. The enclosing assembly is arranged around the first notch, and the enclosing assembly is hermetically connected to the first bracket, the second bracket, and the circuit board. The first bracket, the second bracket, the circuit board, and the enclosing assembly enclose an acoustic chamber of the loudspeaker unit.

Abstract: A device for pressing materials guided by rollers for a carpentry cutting includes a device body, two base body fixing blocks, an adjustment mechanism and two pressing mechanisms. The device body includes a fist base body and a second base body. The two base body fixing blocks are arranged to press both sides of the base body, respectively. The adjustment mechanism includes a pushing mechanism configured to move the two pressing mechanisms along a direction from the first base body toward the second base body, two compressing mechanisms configured to compress a play between the first base body and the pressing mechanisms and a reset mechanism. Each of the pressing mechanisms includes a roller fixing block connected with the sliding block, and two rollers with a same rolling direction, the two rollers are respectively mounted on both sides of the roller fixing block.

Abstract: An antibody may be capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. The antibody or antigen binding fragment thereof may be used in preparing a drug. The antibody or an antigen binding fragment thereof may specifically bind CD137, and may include a light chain variable region VL and a heavy chain variable region VH, wherein compared to a sequence as shown in SEQ ID NO: 103, the VL comprises one or more VL amino acid mutations, and the VL amino acid mutation occurs at one or more positions: V3, A10, K44, D71, and/or V77.

Abstract: Various examples include an apparatus to characterize substrate and film thicknesses of the substrate and films formed thereon. The apparatus uses one or more wavelengths of light from a light source (e.g., a swept laser) to interrogate the substrate. The light is directed substantially orthogonally to an upper surface of the substrate. A polarizer and an analyzer element are coupled between the light source and the substrate. Therefore, the polarizer and the analyzer are both located in the beam propagation path from the light source to the substrate. An optical detector is arranged substantially orthogonally to the upper surface of the substrate. The optical detector receives light returned back from the substrate. The apparatus is capable of determining the thickness of the substrate and one or more films contained thereon, regardless of substrates having optical anisotropies, such as chiral characteristics or stress-induced films. Other apparatuses and methods are also disclosed.

Abstract: The present application provides use of an algal proteoglycan extract and a composition comprising the same in treating or preventing tumor, pain, inflammation or diseases mediated by inflammatory factors.

Abstract: Disclosed herein are embodiments of systems, methods, and products comprising a data power server for secure storage and retrieval of trade data. The server receives a request from a user to review or confirm one or more trade documents via a webserver. The server communicates with a connector grid server to retrieve the user's accessible documents. The connector grid server determines the electronic file IDs that are accessible to the user based on the accessibility policy. The server instructs a digital library server to download the electronic files containing the requested trade data. The digital library server retrieves and downloads the electronic files based on the file IDs. The webserver renders a GUI displaying the electronic files on an electronic client device operated by the user. Upon receiving the confirmation response from the user, the server instructs the digital library server to update the trade status.

Abstract: The present invention relates to a urea compound containing 2-heteroaromatic ring substitution represented by formula (I), its enantiomers, diastereomers, racemates or mixtures thereof, or pharmaceutically acceptable salts thereof, solvate, metabolite or prodrug. The compound of formula (I) of the present invention has inhibitory activity against CDK9, and representative compounds have significant anti-tumor activity against CDK9 high-expressing tumor cells. Representative compounds have plasma stability and low clearance.

Abstract: A method for video frame analysis includes determining a first dissimilarity metric and a second dissimilarity metric. The first dissimilarity metric may correspond to a first difference between a first foreground of a first key frame in a video and a second foreground of a second key frame following the first key frame in the video. The second dissimilarity metric may correspond to a second difference between the second foreground of the second key frame and a third foreground of a third key frame following the second key frame in the video. A playback of the video may be generated based on the first dissimilarity metric and the second dissimilarity metric. Related systems and computer program products are also provided.

Abstract: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

Abstract: A terminal device includes: a housing, where the housing is provided with an interface accommodation hole, a sound guide hole, and a sound guide channel, and the sound guide hole is located in a hole wall of the interface accommodation hole; an interface, where the interface is disposed in the housing, and at least a part of the interface is located in the interface accommodation hole; and an acoustic device, where the acoustic device is disposed in the housing, and the sound guide hole is communicated to the acoustic device through the sound guide channel.

Abstract: The present invention relates to an S-configuration-containing amino benzamide pyridazinone compound, a preparation method therefor, and a pharmaceutical composition and application thereof. Specifically, the present invention relates to a compound represented by the following general formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition and application thereof. The S-configuration compound of the present application has very strong binding activity on class I histone deacetylase (HDAC1), and shows inhibitory activity on in-vitro proliferation of various tumor cells.

Abstract: The present invention relates to novel tricyclic compounds that are AKR1C3 dependent KARS inhibitor, processes for their preparation, pharmaceutical compositions, and medicaments containing them, and their use in diseases and disorders mediated by an AKR1C3 dependent KARS inhibitor.

Abstract: Disclosed herein are polyurethane foams which can be used for reducing or preventing the corrosion of polymeric materials, which can be produced by mixing components (a) at least one polyisocyanate, (b) at least one compound having at least two groups reactive toward isocyanates, (c) optionally chain extender and/or crosslinking agent, (d) blowing agent, (e) catalyst, (f) optionally auxiliaries and additives, and (g) at least one anhydride to give a reaction mixture, and curing said reaction mixture to give the polyurethane foams, where the anhydride is added in an amount of 0.05-5 wt %, based on the weight of component (a). Also disclosed herein are a method of reducing or preventing the corrosion of polymeric materials by using such polyurethane foams and a method of using the polyurethane foams in certain applications, for example, in automotive interiors.

Abstract: The present invention provides a transaction method and a node design in a blockchain system. A client initiates a transaction by using an SQL write command including transaction data or queries transaction data by using an SQL query command. A node parses an SQL command, executes a simulated transaction, and checks block data based on a transaction result of the simulated transaction after obtaining the block data. After the check succeeds, the node converts the block data into an SQL write command used to write the block data, thereby writing the block data to an RDB database. In embodiments of the present invention, an RDB data block is connected to the blockchain system, so that data query and processing capabilities of the blockchain system are improved.

Abstract: Described embodiments provide systems and methods for defining a clip within a recording. A device may generate a recording of a session of a user via which a plurality of applications is accessible. The device may detect a transition of an application of the plurality of applications in a foreground of the session. The device may identify, from the recording, a frame corresponding to the transition in the foreground. The device may store an identification of the frame corresponding to the transition to define a clip of the user within the recording using the application in the session.

Abstract: A method for blockchain generation is provided. The method includes: sending, by a client, transaction information to a first node device, where the transaction information includes basic information and digest information; receiving, by the client, an endorsement result sent by the first node device, where the endorsement result includes a signature generated after the first node device successfully performs transaction simulation; and if the endorsement result meets a preset transaction condition, sending, by the client, the digest information and the endorsement result to a second node device, so that the second node device sends, to the first node device the digest information to generate a complete blockchain. In this way, only the digest information is transmitted between the first node device and the second node device. Therefore, the second node device does not obtain the complete transaction information, so that information security is improved.

Abstract: Provided are compositions and methods for treating cancer comprising the use of a immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy. The immunoconjugate in combination with a cytotoxic agent or cytotoxic therapy shows synergistic effects in cancer treatment.

Abstract: Various examples include an apparatus to characterize substrate and film thicknesses of the substrate and films formed thereon. The apparatus uses one or more wavelengths of light from a light source (e.g., a swept laser) to interrogate the substrate. The light is directed substantially orthogonally to an upper surface of the substrate. A polarizer and an analyzer element are coupled between the light source and the substrate. Therefore, the polarizer and the analyzer are both located in the beam propagation path from the light source to the substrate. An optical detector is arranged substantially orthogonally to the upper surface of the substrate. The optical detector receives light returned back from the substrate. The apparatus is capable of determining the thickness of the substrate and one or more films contained thereon, regardless of substrates having optical anisotropies, such as chiral characteristics or stress-induced films. Other apparatuses and methods are also disclosed.