Abstract: Provided in the present invention are a substituted amino six-membered nitric heterocyclic ring compound and a preparation and use thereof. In particular, provided in the present invention is a compound as shown by general formula (I) below, wherein the definition of each group is as described in the description. The compound of the present invention has an excellent tyrosine kinase inhibitory activity, and can thus be used to prepare a series of medicines for treating diseases related to tyrosine kinase inhibitory activity.

Abstract: Provided is the use of a CSF1R kinase inhibitor compound or a pharmaceutically acceptable salt thereof in the preparation of drugs for treating diseases related to the CSF1R kinase signal transduction pathway or drugs for regulating immunization.

Abstract: The invention discloses a device for testing strength and sealing performance of cement sheath after perforation, comprising a cement sheath curing maintenance simulation component, a perforation operation simulation component, and a cement sheath performance test component.

Abstract: A disproportionation and transalkylation catalyst can be used in the catalytic conversion of alkyl aromatic hydrocarbons. The catalyst contains an acidic molecular sieve, a first metal component immobilized on the acidic molecular sieve and an oxide additive. The first metal contained in the first metal component is at least one selected from the group of Group VB metals, Group VIB metals and Group VIIB metals, the catalyst has a mediate strong acid content of 0.05-2.0 mmol/g of catalyst, and a ratio of the mediate strong acid content to the total acid content of 60-99%. When used in the catalytic conversion of alkyl aromatic hydrocarbons, the catalyst exhibits high reaction activity, low aromatic hydrocarbon loss rate.

Abstract: A stent delivery system for use in an aorta, including: a delivery catheter comprising an outer catheter, an inner catheter, and a push rod that are arranged coaxially and sequentially from outside to inside, and a stent. The stent is a dense-mesh stent. The delivery catheter is configured to cause the outer catheter, the inner catheter, and the push rod to all be able to move relative to one another in the axial direction, and two ends of the stent being removably bound to the proximal end relative to the heart of the push rod and the proximal end relative to the heart of the inner catheter. When the stent delivery system of the disclosure is used in treating aortic aneurysms and/or aortic dissections, the force required for initial release of the stent may be reduced, and local axial compression of the partially released stent may be controlled.

Abstract: Disclosed herein are embodiments of systems, methods, and products comprising a data power server for secure storage and retrieval of trade data. The server receives a request from a user to review or confirm one or more trade documents via a webserver. The server communicates with a connector grid server to retrieve the user's accessible documents. The connector grid server determines the electronic file IDs that are accessible to the user based on the accessibility policy. The server instructs a digital library server to download the electronic files containing the requested trade data. The digital library server retrieves and downloads the electronic files based on the file IDs. The webserver renders a GUI displaying the electronic files on an electronic client device operated by the user. Upon receiving the confirmation response from the user, the server instructs the digital library server to update the trade status.

Abstract: A computing device may include a memory and a processor cooperating with the memory to record data indicative of interactions with shared applications following logons to the computing device, with the data including a number of times and a sequential order of the interactions. The processor may be further configured to determine probabilities of launching the shared applications following a next logon to the computing device from the recorded data, and following the next logon, display shared applications on the display based on the determined probabilities.

Abstract: A device for pressing materials guided by rollers for a carpentry cutting includes a device body, two base body fixing blocks, an adjustment mechanism and two pressing mechanisms. The device body includes a fist base body and a second base body. The two base body fixing blocks are arranged to press both sides of the base body, respectively. The adjustment mechanism includes a pushing mechanism configured to move the two pressing mechanisms along a direction from the first base body toward the second base body, two compressing mechanisms configured to compress a play between the first base body and the pressing mechanisms and a reset mechanism. Each of the pressing mechanisms includes a roller fixing block connected with the sliding block, and two rollers with a same rolling direction, the two rollers are respectively mounted on both sides of the roller fixing block.

Abstract: Described embodiments provide systems and methods for defining a clip within a recording. A device may generate a recording of a session of a user via which a plurality of applications is accessible. The device may detect a transition of an application of the plurality of applications in a foreground of the session. The device may identify, from the recording, a frame corresponding to the transition in the foreground. The device may store an identification of the frame corresponding to the transition to define a clip of the user within the recording using the application in the session.

Abstract: Typically, when a user switches sessions between devices, the user authenticates the sessions by providing user account information, password, and/or pin code input or other credentials. However, when the user is frequently switching sessions between devices, authenticating sessions may result in the user reducing or even stopping switching across mobile devices. Systems and methods according to this disclosure provide automatic session roaming across mobile devices using proximity authentication. Upon detecting an indication to initiate session roaming, the source device automatically roams the session on the source device to a target device based on a proximity of the source device to the target device. The session is handed off from the source device to the target device as an authenticated user session.

Abstract: Methods and systems for using machine learning to provide application recommendations are described herein. A computing device may capture a first edge frame of a first application displayed at the computing device. The computing device may apply machine learning to the first edge frame of the first application to identify a context tag. The computing device may identify applications subsequently accessed in a sequential manner after accessing the first application in a context corresponding to the identified context tag, where each of the applications corresponds to a context level score. The computing device may identify a second application, which may have a higher context level score than remaining applications. Along with the first application, the computing device may display a selectable interface element corresponding to the second application, and selection of the selectable interface element may cause display of an application list that includes the second application.

Abstract: Use of a compound of general formula (A) which is a CFS-1R kinase inhibitor or a pharmaceutically acceptable salt thereof in the preparation of medicaments for treating diseases related to CSF-1R kinase signal transduction pathway or medicaments for regulating immunization. In vivo and in vitro studies show that the compound can significantly inhibit CSF-1R kinase activity; significantly inhibits the proliferation of a CSF-1/CSF-1R-driven mouse myeloid leukemia cell line, inhibits the survival of macrophages induced by CSF-1 and reverses M2 polarization phenotype of macrophages, and has an effect superior to that of the marketed medicament Pexidartinib. In a TAM enriched tumor model (MC38 model), the compound significantly antagonizes the tumor immunosuppressive microenvironment and exhibits significant anti-tumor efficacy.

Abstract: Methods and systems for determining information of applications are described herein. A computing device may receive, from one or more client devices, data indicating application usage events. The computing device may determine, based on the data, popular applications that a target user regularly uses. The computing device may determine, based on the data, recommended applications that users similar to the target user regularly use. The computing device may determine, based on the popular applications and/or the recommended applications, a collection of applications for the target user. The collection of applications may be displayed on a user interface of a client device associated with the target user for expedited access of interested applications.

Abstract: A stent for aorta is formed by weaving at least two types of filaments having different diameters, such as a first filament and a second filament. The stent is configured to be at least partially compressible and extensible along the axial direction of the stent in a natural release state, wherein the first filament has a diameter of 20-150 ?m, and the second filament has a diameter of 150-800 ?m. When the stent is used in the treatment of aortic aneurysm and/or aortic dissection lesions, due to the axial compressibility and extensibility of the stent, low liquid permeability and strong radial support force are provided where needed in the aorta, and due to the axial stretchability thereof, the stent can be easily assembled to a delivery system having an appropriate diameter. Also provided are a stent kit comprising the stent and a stent delivery system.

Abstract: A stent, for use in an aorta, is characterized in that the stent is at least made of a first wire and a second wire of different diameters by means of weaving, and the stent is configured to be at least partially compressible and extensible in the axial direction of the stent in a natural release state, wherein the first wire has a diameter of 20-150 ?m, and the second wire has a diameter of 150-800 ?m. When the stent is used in the treatment of aortic aneurysm lesions and/or aortic dissection lesions, the stent provides low fluid permeability and a strong radial support force at the desired site in the aorta by means of the axial compressibility and extensibility of the stent, and is easily assembled into the delivery system having a suitable diameter. Further provided are the stent kit comprising the stent, and the stent delivery system.

Abstract: A composition including an immunoconjugate and a chemotherapeutic agent. The immunoconjugate includes 1) one or more interleukins, and 2) an Fc domain consisting of a first Fc subunit and a second Fc subunit. The first Fc subunit associates with the second Fc subunit to form a dimer. The one or more interleukins are fused to the Fc domain and the chemotherapeutic agent includes a fluorouracil and/or an oxaliplatin.

Abstract: An axially compressible bare stent for an aorta, formed by interleaving at least two wires having different diameters, i.e., a first wire and a second wire, in an overlapping manner. In a natural release state, the bare stent has a metal coverage of at least 30%. The first wire has a diameter of 20-150 ?m, and the second wire has a diameter of 150-600 ?m. During the use in the treatment of aortic aneurysms and/or aortic dissection lesions, low liquid permeability and a strong radial support force are provided at a desired location in an aorta by means of the axial compressibility of the bare stent.

Abstract: The present application provides use of an algal proteoglycan extract and a composition comprising the same in treating or preventing tumor, pain, inflammation or diseases mediated by inflammatory factors.

Abstract: The present disclosure discloses a miniaturized MOPA structure DPSSL (Diode Pumped Solid State Laser), which comprises a laser oscillator module and a laser amplifier module. The laser oscillator module consists of a seed laser and its collimating system, and the laser amplifier module consists of a laser pump module and a laser gain element. The seed laser with high beam quality is collimated by collimation system, then input into the gain element; the pump laser is pumped into the gain element via end pump or side pump mode. The seed laser beam transmits into the gain medium and is reflected by the interface several times with the “Zigzag” path, which makes the seed laser fully gained and amplified, finally achieving high power and high beam quality laser output. In this present disclosure, the laser gain material is doped with different rare-earth ion concentrations and processed into different shapes.

Abstract: A method for video frame analysis includes determining a first dissimilarity metric and a second dissimilarity metric. The first dissimilarity metric may correspond to a first difference between a first foreground of a first key frame in a video and a second foreground of a second key frame following the first key frame in the video. The second dissimilarity metric may correspond to a second difference between the second foreground of the second key frame and a third foreground of a third key frame following the second key frame in the video. A playback of the video may be generated based on the first dissimilarity metric and the second dissimilarity metric. Related systems and computer program products are also provided.