Patents by Inventor Jian Lin

Jian Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10456382
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: October 29, 2019
    Assignees: FORMA TM, LLC, Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Peter Dragovich, Francis Gosselin, Bingsong Han, Jian Lin, Dominic J. Reynolds, Bruce Roth, Chase C. Smith, Zhongguo Wang, Po-Wai Yuen, Xiaozhang Zheng
  • Publication number: 20190313631
    Abstract: A method for controlling Aurelia spp. blooms in harbors includes: designing different sites at equal intervals in an area in spring, collecting ephyrae of Aurelia spp. with an I-type trawl net for zooplankton from bottom to surface, determining whether polyps of Aurelia spp. inhabit in the vicinity of the sites; seeking large floating substrates that the polyps attach to using scuba diving in the determined habitats of the polyps; dragging the substrates to a shore base and scraping off all organisms attached to bottom surfaces of the substrates in a physical manner, then air drying the substrates for 7 days or more; and applying an antifouling paint on the bottom surfaces of the dried substrates followed by drying, then returning the substrates back to their original sites in the sea to control the bloom of Aurelia spp. in the area.
    Type: Application
    Filed: January 28, 2019
    Publication date: October 17, 2019
    Inventors: Song FENG, Fang ZHANG, Jianing LIN, Minxiao WANG, Shiwei WANG, Song SUN
  • Publication number: 20190296975
    Abstract: A computer program product and a computer system for distributed dynamic sizing and load self-management for a relay infrastructure. Program instructions are executable to initiate, by the non-leaving relay in a relay infrastructure, an expansion process, in response to determining that a current load level reaches an expansion level and in response to determining that an overload condition of the relay infrastructure is satisfied; send to a server, by the non-leaving relay, an expansion message, in response to initiating the expansion process; send to the server, by the non-leaving relay, local statistics of endpoints of the non-leaving relay; shift, by the non-leaving relay, one or more endpoints of the non-leaving relay to a first new relay, in response to the server selecting from the endpoints an endpoint and converting the endpoint to the first new relay.
    Type: Application
    Filed: June 10, 2019
    Publication date: September 26, 2019
    Inventors: PAUL COCCOLI, BRADFORD A. FISHER, NATHAN P. FRITH, JIAN LIN
  • Patent number: 10414752
    Abstract: The application relates to an inhibitor of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I-13):
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: September 17, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, Jr., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190275635
    Abstract: An edging method is provided, comprising: providing an edging apparatus comprising at least one sensor configured to detect a distance from the sensor to the edge to be ground; providing a workpiece having an edge to be ground; setting a base value of the distance; detecting a variation value, the variation value is a difference between a present distance from the sensor to the edge to be ground during grinding and the base value; and regulating a grinding feed amount of the edging apparatus according to the variation value. An edging apparatus is further provided.
    Type: Application
    Filed: August 27, 2018
    Publication date: September 12, 2019
    Inventors: Junzhao Gao, Jian Lin, Kai Zhu, Weibin Qi
  • Patent number: 10408880
    Abstract: More accurate and robust battery state estimation (BSE) techniques for a battery system of an electrified vehicle include estimating a current bias or offset generated by a current sensor and then adjusting the measured current to compensate for the estimated current bias. The techniques obtain nominal parameters for a battery model of the battery system based on a measured temperature and an estimated open circuit voltage (OCV). The techniques use these nominal parameters and the corrected measured current to estimate the OCV, a capacity, and an impedance of the battery system. The techniques utilize the OCV to estimate a state of charge (SOC) of the battery system. The techniques also estimate a state of health (SOH) of the battery system based on its estimated capacity and impedance. The techniques then control the electrified vehicle based on the SOC and/or the SOH.
    Type: Grant
    Filed: August 19, 2014
    Date of Patent: September 10, 2019
    Assignee: FCA US LLC
    Inventors: Jian Lin, Hong Yang, Pawel Malysz, Jin Ye, Ran Gu, Ali Emadi
  • Patent number: 10407419
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: (I) where Y1, X1, X2, Y2, W1, W2, W3, and R1-R5 are described herein.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: September 10, 2019
    Assignee: Forma Therapeutics, Inc.
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, Jr., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190270721
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
    Type: Application
    Filed: May 22, 2019
    Publication date: September 5, 2019
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Bingsong Han, Jian Lin, Dominic J. Reynolds, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng, Po-Wai Yuen
  • Patent number: 10399980
    Abstract: The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: where R1, R2, R3, R3?, R4, R5, X1, X2, X3, X4, and n are described herein.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 3, 2019
    Assignee: FORMA Therapeutics, Inc.
    Inventors: Alexandre Joseph Buckmelter, Stephanos Ioannidis, Bruce Follows, Gary Gustafson, Minghua Wang, Justin A. Caravella, Zhongguo Wang, Edward L. Fritzen, Jian Lin
  • Publication number: 20190263779
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R6 are described herein.
    Type: Application
    Filed: March 1, 2019
    Publication date: August 29, 2019
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, JR., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190263778
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
    Type: Application
    Filed: March 1, 2019
    Publication date: August 29, 2019
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, JR., Justin Andrew Caravella, Wei Lu
  • Patent number: 10397054
    Abstract: Methods for distributed dynamic sizing and load self-management for a relay infrastructure. In one method, a relay in a relay infrastructure determines whether a current load level of the relay reaches an expansion level of the relay and whether an overload condition of the relay infrastructure is satisfied, and the relay initiates an expansion process in response to the determination. In another method, a relay in a relay infrastructure determines whether in response to determining that an underload condition of the relay infrastructure is satisfied, and the relay initiates a contraction process in response to the determination. In yet another method, a relay in a relay infrastructure determines whether a tolerance-load condition of the relay infrastructure is satisfied, and the relay in initiates a load self-management process in response to the determination.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: August 27, 2019
    Assignee: International Business Machines Corporation
    Inventors: Paul Coccoli, Bradford A. Fisher, Nathan P. Frith, Jian Lin
  • Publication number: 20190245673
    Abstract: A communication device and an echo cancellation method are provided. A digital echo canceller is coupled to a transmitting circuit and a receiving circuit to generate an echo energy indicator according to a digital output signal and a digital input signal. A transceiving front-end circuit receives the analog output signal and generates a hybrid interface signal. A hybrid fine-tune circuit generates a first and a second capacitance calibration signals according to the echo energy indicator. An analog echo cancellation circuit receives the first and second capacitance calibration signals, and includes a first and a second variable capacitors controlled by the first capacitance calibration signal and a third and a fourth variable capacitors controlled by the second capacitance calibration signal. The analog echo cancellation circuit receives the analog output signal and the hybrid interface signal, and generates the analog input signal according to the first and second capacitance calibration signals.
    Type: Application
    Filed: July 12, 2018
    Publication date: August 8, 2019
    Applicant: ALi Corporation
    Inventors: Wei-Jian Lin, Zhi-Ming Zeng
  • Publication number: 20190210970
    Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 11, 2019
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, JR., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190210995
    Abstract: The invention relates to methods of reducing the level of 2-hydroxyglutarate in cells by administration of an inhibitor of mutant isocitrate dehydrogenase-1.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 11, 2019
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, JR., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190202790
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
    Type: Application
    Filed: March 12, 2019
    Publication date: July 4, 2019
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, JR., Justin Andrew Caravella, Wei Lu
  • Patent number: 10329275
    Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: June 25, 2019
    Assignees: FORMA TM, LLC, Genentech, Inc.
    Inventors: Kenneth W. Bair, Timm R. Baumeister, Alexandre J. Buckmelter, Karl H. Clodfelter, Bingsong Han, Jian Lin, Dominic J. Reynolds, Chase C. Smith, Zhongguo Wang, Xiaozhang Zheng, Po-Wai Yuen
  • Patent number: 10305986
    Abstract: A cloud-based storage service hosts content information that may be accessed by client machines in a peer-to-peer network. The content information is a compact representation of the content which is stored outside of the cloud-based storage service. The cloud-based storage service generates the content information and a content information hash. The content information hash is used to validate the content information when the content information is downloaded to the peer-to-peer network. The cloud-based storage service also generates metadata that describes the content information so that a client machine in the peer-to-peer network may access the content information from the cloud-based storage service.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: May 28, 2019
    Assignee: MICROSOFT TECHNOLOGY LICENSING, LLC.
    Inventors: Daniel Kappes, Jian Lin, Igor Liokumovich, Hemant Nanivadekar, Mandar Gokhale
  • Patent number: 10294206
    Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: May 21, 2019
    Assignee: FORMA TM2, INC.
    Inventors: Jian Lin, Anna Ericsson, Ann-Marie Campbell, Gary Gustafson, Zhongguo Wang, R. Bruce Diebold, Susan Ashwell, David R. Lancia, Jr., Justin Andrew Caravella, Wei Lu
  • Publication number: 20190148839
    Abstract: A multi-band antenna array includes first antenna elements and second antenna elements. Each first antenna element has a first shape spanned by a first long axis and a first short axis, the first long axis being longer than and perpendicular to the first short axis. Each second antenna element has a second shape spanned by a second long axis and a second short axis, the second long axis being longer than and perpendicular to the second short axis. The first long axis is non-parallel to the second long axis. The first antenna element and the second antenna element resonate at a high resonance frequency band along the first long axis and the second long axis, respectively, and the first antenna element and the second antenna element further resonate at a low resonance frequency band along the first short axis and the second short axis, respectively.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 16, 2019
    Inventors: Wun-Jian Lin, Shyh-Tirng Fang, Yeh-Chun Kao